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Ontology Browser

Term:
negative regulation of hh target transcription factor activity (GO:1990787)
Annotations: Rat: (1) Mouse: (1) Human: (1) Chinchilla: (1) Bonobo: (1) Dog: (0) Squirrel: (0) Pig: (0)
Parent Terms Term With Siblings Child Terms
negative regulation of DNA-binding transcription factor activity +   
negative regulation of hh target transcription factor activity  
Any process that decreases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates members of the Gli protein family are activated by Hedgehog signaling.
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning  
negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning  
positive regulation of DNA-binding transcription factor activity +   

Synonyms
Exact Synonyms: negative regulation of hedgehog target transcription factor
Xrefs: IntAct:EBI-10170144
Definition Sources: GOC:bhm, PMID:24311597

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.