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Ontology Browser

Term:
abnormal uterine spiral artery remodeling (MP:0012727)
Annotations: Rat: (1) Mouse: (5) Human: (0) Chinchilla: (0) Bonobo: (0) Dog: (0) Squirrel: (0) Pig: (0)
Parent Terms Term With Siblings Child Terms
abnormal uterine spiral artery remodeling  
any anomaly of the physiological conversion of the uterine spiral arteries into highly dilated vessels by the action of invading trophoblast; in pregnancy, trophoblast invasion and uterine spiral artery remodeling are important for lowering maternal vascular resistance and increasing uteroplacental blood flow; this process involves loss of smooth muscle and elastic lamina from the vessel wall, and significant dilation at the mouth of the vessel; impaired spiral artery remodeling has been implicated in preeclampsia, fetal growth restriction, and preterm labor

Synonyms
Exact Synonyms: abnormal decidual spiral artery remodeling ;   abnormal endometrial spiral artery remodeling ;   abnormal maternal spiral artery remodeling ;   abnormal uterine spiral artery modification
Definition Sources: MGI:anna

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.