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View Ontology Report


Autophagy, the catabolic pathway of cytoplasmic degradation, is essential for cellular and tissue homeostasis and it can act as a source of nutrients under starvation or stress conditions. Autophagy encompasses macro and microautophagy, conserved across species, and chaperone-mediated autophagy (CMA) which appears to be confined to mammalian cells. Macroautophagy (autophagy hereafter) is the pathway described here and shown in the diagram. It involves the sequestration of damaged organelles and

Pathway Diagram:

Ariadne Genomics Inc. Lamp members SNARE, ESCRT, Rabs Atg4 members Atg9 members LC3 conjugation system Atg12 conjugation system Pik3c3 Pik3r4 Atg14 Rb1cc1 Ulk1 mTOR signaling pathway PtdIns3P Atg4 members ---> LC3 conjugation system starvation ---| mTOR signaling pathway nutrient-rich --+> mTOR signaling pathway starvation nutrient-rich Becn1 ---- Uvrag Ulk2 --+> Atg13 Ulk1 --+> Rb1cc1 Becn1 class III PI3K complex Becn1 ---- Rubicon mTOR signaling pathway ---| Ulk1 mTOR signaling pathway ---| Ulk2 Rubicon Uvrag Atg12 conjugation system ---> LC3 conjugation system Acp2 ---> degradation Acp2 degradation Lamp members ---> degradation Ulk2 Atg13 Atg13 ---- Rb1cc1 Pik3c3 ---> PtdIns3P PE Ulk/Atg13/Atg17 complex class III PI3K complex ---> Atg12 conjugation system

Genes in Pathway:

show annotations for term's descendants       view all columns           Sort by:
autophagy pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acp2 acid phosphatase 2, lysosomal JBrowse link 3 80,020,346 80,030,365 RGD:4892631
G Atg10 autophagy related 10 JBrowse link 2 19,853,546 20,152,918 RGD:1643329
G Atg12 autophagy related 12 JBrowse link 18 40,721,799 40,732,143 RGD:1643329
G Atg13 autophagy related 13 JBrowse link 3 80,580,549 80,614,554 RGD:4889529
G Atg14 autophagy related 14 JBrowse link 15 24,343,418 24,374,776 RGD:4889529
G Atg16l1 autophagy related 16-like 1 JBrowse link 9 94,879,876 94,915,231 RGD:1643329
G Atg16l2 autophagy related 16-like 2 JBrowse link 1 166,401,271 166,415,078 RGD:1643329
G Atg3 autophagy related 3 JBrowse link 11 60,585,192 60,613,706 RGD:1643237
G Atg4a autophagy related 4A, cysteine peptidase JBrowse link X 112,328,907 112,403,157 RGD:1643329
G Atg4b autophagy related 4B, cysteine peptidase JBrowse link 9 100,888,457 100,920,123 RGD:1643329
G Atg4c autophagy related 4C, cysteine peptidase JBrowse link 5 117,861,517 117,932,116 RGD:1643329
G Atg4d autophagy related 4D, cysteine peptidase JBrowse link 8 22,291,445 22,301,331 RGD:1643329
G Atg5 autophagy related 5 JBrowse link 20 49,301,783 49,393,147 RGD:2301217
G Atg7 autophagy related 7 JBrowse link 4 146,570,113 146,777,093 RGD:1643329
G Atg9a autophagy related 9A JBrowse link 9 82,382,800 82,393,429 RGD:4889529
G Atg9b autophagy related 9B JBrowse link 4 7,314,369 7,322,095 RGD:4889529
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:1643194
G Chmp2b charged multivesicular body protein 2B JBrowse link 11 2,666,405 2,692,213 RGD:4892619
G Chmp3 charged multivesicular body protein 3 JBrowse link 4 99,449,213 99,496,156 RGD:4892619
G Gabarap GABA type A receptor-associated protein JBrowse link 10 56,601,288 56,604,223 RGD:1643329
G Gabarapl1 GABA type A receptor associated protein like 1 JBrowse link 4 163,293,724 163,302,866 RGD:4890444
G Gabarapl2 GABA type A receptor associated protein like 2 JBrowse link 19 44,164,935 44,175,771 RGD:1643329
G Hgs hepatocyte growth factor-regulated tyrosine kinase substrate JBrowse link 10 109,638,944 109,657,460 RGD:4892619
G Ifna1 interferon, alpha 1 JBrowse link 5 106,951,822 106,952,908 RGD:6907045
G Ifna11 interferon alpha family, gene 11 JBrowse link 5 107,504,741 107,505,783 RGD:6907045
G Ifna2 interferon alpha 2 JBrowse link 5 107,416,117 107,416,695 RGD:6907045
G Ifna4 interferon, alpha 4 JBrowse link 5 106,922,563 106,923,132 RGD:6907045
G Ifna5 interferon, alpha 5 JBrowse link 5 107,039,347 107,039,925 RGD:6907045
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6907045
G Ins1 insulin 1 JBrowse link 1 272,799,784 272,800,351 RGD:6907045
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:6907045
G Lamp1 lysosomal-associated membrane protein 1 JBrowse link 16 81,689,576 81,714,341 RGD:4892310
G Lamp2 lysosomal-associated membrane protein 2 JBrowse link X 124,722,628 124,766,079 RGD:4892310
G LOC100911527 interferon alpha-12-like JBrowse link 5 87,328,395 87,328,946 RGD:6907045
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha JBrowse link 3 150,801,289 150,802,935 RGD:1643198
G Map1lc3b microtubule-associated protein 1 light chain 3 beta JBrowse link 19 53,635,449 53,643,970 RGD:1643329
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 JBrowse link 18 22,964,121 23,047,896 RGD:4889529
G Pik3r4 phosphoinositide-3-kinase, regulatory subunit 4 JBrowse link 8 114,300,248 114,350,686 RGD:4889529
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 JBrowse link 2 54,857,688 54,893,404 RGD:6907045
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 JBrowse link 5 124,568,845 124,642,569 RGD:6907045
G Rab11a RAB11a, member RAS oncogene family JBrowse link 8 70,192,975 70,215,719 RGD:4892310
G Rab33b RAB33B, member RAS oncogene family JBrowse link 2 140,541,619 140,552,220 RGD:4892310
G Rab5a RAB5A, member RAS oncogene family JBrowse link 9 5,910 6,065 RGD:4892310
G Rab7a RAB7A, member RAS oncogene family JBrowse link 4 119,910,461 119,963,065 RGD:4892310
G Rb1cc1 RB1-inducible coiled-coil 1 JBrowse link 5 13,033,918 13,097,369 RGD:4889529
G Rubcn rubicon autophagy regulator JBrowse link 11 71,150,506 71,199,254 RGD:4889529
G Snf8 SNF8 subunit of ESCRT-II JBrowse link 10 83,856,331 83,868,621 RGD:4892619
G Tsg101 tumor susceptibility 101 JBrowse link 1 102,941,151 102,971,017 RGD:4892619
G Ulk1 unc-51 like autophagy activating kinase 1 JBrowse link 12 51,908,105 51,934,704 RGD:1643329
G Ulk2 unc-51 like autophagy activating kinase 2 JBrowse link 10 48,050,079 48,129,377 RGD:4889529
G Ulk3 unc-51 like kinase 3 JBrowse link 8 62,368,548 62,375,229 RGD:6907045
G Uvrag UV radiation resistance associated JBrowse link 1 163,844,804 164,101,568 RGD:4889529
G Vamp3 vesicle-associated membrane protein 3 JBrowse link 5 168,126,157 168,136,628 RGD:4892310
G Vamp7 vesicle-associated membrane protein 7 JBrowse link 12 18,996,566 19,033,714 RGD:4892310
G Vps4a vacuolar protein sorting 4 homolog A JBrowse link 19 39,230,050 39,243,298 RGD:4892619

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupLamp membersautolysosome degradation proteins
Gene GroupRab, ESCRT, SNARE membersautophagosome, autolysosome, amphisome proteins
Gene GroupAtg4 membersmembers of Atg4 proteases that prime Lc3/Atg8
Gene GroupLC3 conjugation systemphagophore closure proteins
Gene GroupAtg12 conjugation systemphagophore elongation proteins
Small MoleculePEphosphatidylethanolamine
Small MoleculePtdIns3Pphosphatidylinositol 3-phosphate
Gene GroupAtg9 membersthe transmembrane Atg9 proteins

Pathway Gene Annotations

Disease Annotations Associated with Genes in the autophagy pathway
Disease TermsGene Symbols
16Q24.3 Microdeletion SyndromeMap1lc3b
Acid Phosphatase DeficiencyAcp2
acquired immunodeficiency syndromeIfng
acute disseminated encephalomyelitisIfng
acute kidney failureIns2
Acute Liver FailureIns1 , Ins2
Acute Lung InjuryIfng , Prkaa1
Acute Necrotizing PancreatitisBecn1
acute promyelocytic leukemiaIfng
acute retinal necrosis syndromeIfng
adult T-cell leukemiaIfng
Alcoholic IntoxicationIfng
allergic conjunctivitisIfng
allergic contact dermatitisIfng
allergic hypersensitivity diseaseIfng
allergic rhinitisIfng
Alzheimer's diseaseBecn1 , Ins1 , Ins2
amyotrophic lateral sclerosisAtg5 , Becn1 , Chmp2b , Map1lc3a
amyotrophic lateral sclerosis type 17Chmp2b
anemiaAtg5 , Atg7
Animal Disease ModelsIfng
anterior ischemic optic neuropathyBecn1
anterior uveitisIfng
aplastic anemiaIfng
ataxia telangiectasiaIfng
atopic dermatitisIfng
autistic disorderAtg12 , Atg4a , Ifng , Lamp2 , Rb1cc1 , Ulk2 , Vamp7
Autoimmune DiseasesIfng
autoimmune hepatitisIfng
autoimmune thyroiditisIfng
autosomal recessive spinocerebellar ataxia 15Rubcn
autosomal recessive spinocerebellar ataxia 25Atg5
B-Cell Chronic Lymphocytic LeukemiaIfng
Barrett's esophagusBecn1
Behcet's diseaseIfng
bipolar disorderIns2
bladder diseaseIns2
brain diseaseIfng
brain infarctionBecn1
Brain InjuriesAtg12 , Becn1 , Map1lc3a
Brain Injuries, TraumaticLamp2
brain ischemiaBecn1
breast adenocarcinomaRb1cc1
breast cancerIfng , Prkaa1 , Rb1cc1 , Tsg101
Breast Cancer, FamilialTsg101
breast carcinomaTsg101
Breast NeoplasmsAtg10 , Ifng , Rb1cc1
Bronchial HyperreactivityIfng
bronchiolitis obliteransIfng
BurnsBecn1 , Map1lc3a
cardiac arrestIfng , Ins2
CardiomegalyAtg16l1 , Atg5 , Becn1 , Map1lc3a , Prkaa2
cardiomyopathyIfng , Lamp2 , Prkaa2
celiac diseaseIfng
Cerebral HemorrhageBecn1 , Map1lc3a
cervix carcinomaTsg101
Chagas diseaseIfng
Charcot-Marie-Tooth diseaseRab7a
Charcot-Marie-Tooth disease type 2Rab7a
Charcot-Marie-Tooth disease type 2BRab7a
Chemical and Drug Induced Liver InjuryAtg5 , Ifng , Map1lc3b , Prkaa1
cholestasisLamp2 , Prkaa1
chromosome 3-linked frontotemporal dementiaChmp2b
chronic conjunctivitisLamp2
chronic granulomatous diseaseIfng
Chronic Hepatitis BIfng
Chronic Intermittent HypoxiaBecn1 , Map1lc3a
Chronic PancreatitisIfng
Chronic ThyroiditisIfng
cognitive disorderIns2 , Lamp2
colon cancerPrkaa1
Colonic NeoplasmsBecn1 , Ifng
Combined Pituitary Hormone Deficiency, 2Chmp2b
congestive heart failureBecn1 , Ifng , Ins2
Corneal PerforationIfng
Crohn's diseaseAtg16l1 , Ifng
cutaneous leishmaniasisIfng
cystic kidney diseaseIns2
Danon diseaseLamp2
degenerative disc diseaseBecn1 , Map1lc3a
Delayed HypersensitivityIfng
Developmental DisabilitiesRubcn
Diabetes ComplicationsPrkaa1
diabetes mellitusIns1 , Ins2
Diabetes Mellitus, Experimental Atg7 , Becn1 , Ifng
Diabetic CardiomyopathiesIns2
diabetic ketoacidosisIns2
Diabetic NephropathiesBecn1 , Ifng , Ins2
diabetic neuropathyBecn1 , Ifng
diabetic retinopathyIns2
dilated cardiomyopathyLamp2
disease of cellular proliferationIfng
disease of metabolismIns2
Drug EruptionsIfng
dry eye syndromeIfng
eczema herpeticumIfng
end stage renal failureBecn1
endometrial adenocarcinomaTsg101
EndotoxemiaIfng , Prkaa1
esophagus adenocarcinomaBecn1
Experimental ArthritisIfng
Experimental Autoimmune EncephalomyelitisIfng , Prkaa1
Experimental Autoimmune UveoretinitisIfng
Experimental ColitisIfng
Experimental Liver CirrhosisIfng , Ins2 , Map1lc3a
Experimental NeoplasmsIfng
Experimental Pancreatitis, Acute Becn1 , Lamp2 , Map1lc3a
Experimental SarcomaIfng
Experimental SeizuresBecn1
eyelid diseaseIfng
factor VIII deficiencyIfng
familial hypertrophic cardiomyopathyLamp2
Fanconi anemiaIfng
fatty liver diseaseIns2 , Prkaa1
frontotemporal dementiaChmp2b
Frontotemporal Lobar DegenerationChmp2b
genital herpesIfng
gestational diabetesIns2
glaucomaBecn1 , Map1lc3a
glioblastoma multiformeBecn1 , Map1lc3a
glucose intoleranceIns2 , Prkaa1 , Prkaa2
glucosephosphate dehydrogenase deficiencyIfng
Graft vs Host DiseaseIfng
Graves OphthalmopathyIfng
Graves' diseaseIfng
Hantavirus hemorrhagic fever with renal syndromeIfng
Hashimoto DiseaseIfng
Head Injuries, ClosedBecn1
Heat StrokeBecn1
Helicobacter InfectionsPrkaa1
Hemorrhagic ShockIfng
hepatitisIfng , Ins2
hepatitis BIfng
hepatitis CIfng
hepatocellular carcinomaAtg7 , Ins1
Hereditary Neoplastic SyndromesAtg12
herpes simplex virus keratitisIfng
High MyopiaPrkaa2
Hirschsprung's diseaseSnf8
human immunodeficiency virus infectious diseaseIfng
Huntington's diseasePrkaa1
hyper IgE syndromeIfng
HyperalgesiaBecn1 , Map1lc3a
HyperproinsulinemiaIns1 , Ins2
hypersensitivity reaction type III diseaseIfng
hypertensionAtg7 , Becn1 , Ins2 , Map1lc3a
hypertrophic cardiomyopathyAcp2 , Becn1 , Ins2 , Lamp2 , Map1lc3a
HypotensionIfng , Ins2
Hypoxia-Ischemia, BrainBecn1 , Map1lc3a
inflammatory bowel diseaseAtg16l1 , Ifng
inflammatory bowel disease 10Atg16l1
Insulin ResistanceIns2 , Prkaa1 , Prkaa2
intellectual disabilityAtg4c
Intestinal HelminthiasisIfng
intrahepatic cholangiocarcinomaBecn1
ischemiaAtg5 , Becn1 , Map1lc3a
Kidney CalculiIfng
kidney failureIfng , Ins2
Kidney Reperfusion InjuryBecn1 , Ifng , Map1lc3a
Legionnaires' diseaseIfng
LethargyAtg5 , Atg7
Lewy body dementiaBecn1 , Ins2
lichen planusIfng
liver cirrhosisBecn1 , Ifng , Map1lc3a
liver diseaseIns2
long QT syndromeAtg9b , Map1lc3a
Lung NeoplasmsBecn1 , Ifng
lupus nephritisIfng
lymphopeniaAtg5 , Atg7
lymphoproliferative syndromeIfng
Machado-Joseph diseaseBecn1
malignant gliomaAtg7 , Ifng
malignant mesotheliomaIfng , Ulk2
Manganese PoisoningIfng
maturity-onset diabetes of the youngIns1 , Ins2
maturity-onset diabetes of the young type 10Ins1 , Ins2
Memory DisordersIns2
mental depressionBecn1 , Map1lc3a
Metabolic SyndromeIns2
Micronuclei, Chromosome-DefectiveIns2
middle cerebral artery infarctionBecn1
mixed connective tissue diseaseIfng
MPTP PoisoningIns2
mucocutaneous leishmaniasisIfng
multiple sclerosisIfng
muscular diseaseIns2
Mycobacterium InfectionsIfng
Mycoplasma pneumoniae pneumoniaIfng
myelodysplastic syndromeAtg7
myeloid leukemiaIfng
myocardial infarctionAtg7 , Becn1 , Lamp2 , Map1lc3a
Myocardial IschemiaMap1lc3b , Rab5a , Rab7a
Myocardial Reperfusion InjuryBecn1 , Map1lc3a
myofibrillar myopathy 1Atg9a
Nasal PolypsIfng
NecrosisAtg5 , Atg7 , Ifng
nemaline myopathy 6Rab11a
neonatal diabetes mellitusIns1 , Ins2
Neoplasm InvasivenessIns2
Nerve DegenerationBecn1 , Ifng , Map1lc3a
neural tube defectIfng , Ins2
neurodegenerative diseaseAtg7
Neurodevelopmental DisordersAtg10 , Atg12 , Atg7 , Atg9a , Prkaa1 , Vamp3
obesityIfng , Ins2
oral submucous fibrosisIfng
osteoarthritisBecn1 , Ins2
Osteoarthritis, ExperimentalBecn1 , Map1lc3a , Ulk1
otitis mediaIfng
Otitis Media with EffusionIfng
ovarian cancerTsg101
Ovarian NeoplasmsAtg5 , Atg7
pancreatic cancerIfng , Ins2
pancreatic ductal carcinomaIns2
panic disorderIns2
Papillomavirus InfectionsVamp7
paraplegiaAtg7 , Becn1
Parkinson's diseaseAtg7 , Ins2
Parkinsonian DisordersBecn1
pathologic nystagmusRubcn
perinatal necrotizing enterocolitisBecn1
peritonitisBecn1 , Ifng
permanent neonatal diabetes mellitusIns1 , Ins2
Phelan-McDermid syndromeIns2
pleural diseaseIfng
polycystic kidney diseaseBecn1
polycystic ovary syndromeIns2
Potocki-Lupski syndromeUlk2
pre-malignant neoplasmPrkaa1
precursor lymphoblastic lymphoma/leukemiaIfng
prostate cancerAtg13 , Ins2 , Tsg101 , Ulk2 , Uvrag
Prostatic NeoplasmsIns2
Radiation Injuries, ExperimentalIfng
relapsing polychondritisIfng
renal fibrosisIfng
Reperfusion InjuryBecn1 , Ifng
respiratory syncytial virus infectious diseaseIfng
respiratory system diseaseIfng
retinal detachmentMap1lc3a
rheumatoid arthritisIfng
Salmonella Infections, AnimalIfng
schizophreniaBecn1 , Ifna1 , Ifna4 , Rb1cc1 , Ulk3
sciatic neuropathyLamp2
Segawa Syndrome, Autosomal RecessiveIns1 , Ins2
selective IgG deficiency diseaseIfng
sensorineural hearing lossIfng
septic arthritisIfng
Severe Growth Restriction with Distinctive FaciesIns1
Silver-Russell syndromeIns1
Sjogren's syndromeIfng
Smith-McCort dysplasiaRab33b
Smith-McCort Dysplasia 2Rab33b
Spinal Cord InjuriesAtg5 , Atg7 , Becn1 , Map1lc3a , Map1lc3b , Ulk1
Spinal Cord Reperfusion InjuryBecn1
Spinocerebellar AtaxiasRubcn
status asthmaticusIfng
status epilepticusBecn1 , Lamp2
Stevens-Johnson syndromeIfng
Stomach NeoplasmsPrkaa1
Subarachnoid HemorrhageBecn1
Sudden Death, CardiacLamp2
suppurative otitis mediaIfng
syndromic X-linked intellectual disability Lubs typeAtg4a , Lamp2
systemic lupus erythematosusAtg5 , Atg7 , Becn1 , Ifng , Rubcn
systemic sclerodermaIfng
temporal arteritisIfng
Temporomandibular Joint DisordersBecn1 , Map1lc3a
tongue squamous cell carcinomaIfng
transient cerebral ischemiaBecn1 , Map1lc3a
Transplant RejectionIfng
Trifascicular BlockLamp2
tuberous sclerosisIfng
tuberous sclerosis 2Ifng
type 1 diabetes mellitusIfng , Ins2
type 1 diabetes mellitus 2Ins1 , Ins2
type 2 diabetes mellitusBecn1 , Ifng , Ins1 , Ins2 , Map1lc3a , Prkaa1 , Prkaa2
ureteral obstructionBecn1 , Ifng
urinary bladder cancerIfng
Ventricular Dysfunction, LeftIns2 , Prkaa2
Ventricular FibrillationIns2
Ventricular Outflow ObstructionIns2
vesicoureteral refluxIfng
viral encephalitisBecn1
Viral MyocarditisIfng
visceral leishmaniasisIfng
visual epilepsyAcp2 , Ifng , Ins2
Vogt-Koyanagi-Harada diseaseIfng
Weight LossAtg5 , Atg7 , Ins2
Weissenbacher-Zweymuller syndromeGabarap
X-linked Alport syndromeAtg4a
Pathway Annotations Associated with Genes in the autophagy pathway
Pathway TermsGene Symbols
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayPrkaa1 , Prkaa2
aldosterone signaling pathwayIns1 , Ins2
allograft rejection pathwayIfng
altered insulin signaling pathwayIns2
amyotrophic lateral sclerosis pathwayRab5a
antigen processing and presentation pathwayIfng
autoimmune thyroiditis pathwayIfna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , LOC100911527
autophagy pathwayAcp2 , Atg10 , Atg12 , Atg13 , Atg14 , Atg16l1 , Atg16l2 , Atg3 , Atg4a , Atg4b , Atg4c , Atg4d , Atg5 , Atg7 , Atg9a , Atg9b , Becn1 , Chmp2b , Chmp3 , Gabarap , Gabarapl1 , Gabarapl2 , Hgs , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifng , Ins1 , Ins2 , Lamp1 , Lamp2 , LOC100911527 , Map1lc3a , Map1lc3b , Pik3c3 , Pik3r4 , Prkaa1 , Prkaa2 , Rab11a , Rab33b , Rab5a , Rab7a , Rb1cc1 , Rubcn , Snf8 , Tsg101 , Ulk1 , Ulk2 , Ulk3 , Uvrag , Vamp3 , Vamp7 , Vps4a
bile acid signaling pathwayPrkaa1
Chagas disease pathwayIfng
chaperone mediated autophagy pathwayLamp2
cytokine mediated signaling pathwayIfna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifng , LOC100911527
eicosanoid signaling pathwayRab11a
endocytosis pathwayChmp2b , Hgs , Rab11a , Rab5a , Rab7a , Snf8 , Tsg101 , Vps4a
Entamoebiasis pathwayIfng , Rab5a , Rab7a
forkhead class A signaling pathwayIns2
gliclazide pharmacodynamics pathwayIns2
glyburide pharmacodynamics pathwayIns2
graft-versus-host disease pathwayIfng
hepatitis C pathwayIfna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , LOC100911527
hypertrophic cardiomyopathy pathwayPrkaa1 , Prkaa2
influenza A pathwayIfna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifng , LOC100911527
inositol metabolic pathwayBecn1 , Pik3c3 , Pik3r4
inositol phosphate metabolic pathwayPik3c3
insulin responsive facilitative sugar transporter mediated glucose transport pathwayIns2 , Rab11a , Rab5a
insulin signaling pathwayIns1 , Ins2 , Prkaa1 , Prkaa2
interleukin-12 signaling pathwayIfng , Rab7a
interleukin-2 signaling pathwayIfng
interleukin-23 signaling pathwayIfng
interleukin-27 signaling pathwayIfng
Jak-Stat signaling pathwayIfna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifng , LOC100911527
Leishmaniasis pathwayIfng
malaria pathwayIfng
maturity-onset diabetes of the young pathwayIns1 , Ins2
measles pathwayIfna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifng , LOC100911527
mitochondrial autophagy pathwayAtg7 , Becn1 , Ulk1
mTOR signaling pathwayAtg13 , Ins1 , Ins2 , Prkaa1 , Prkaa2 , Rb1cc1 , Ulk1 , Ulk2 , Ulk3
Notch signaling pathwayRab11a
phagocytosis pathwayHgs , Lamp1 , Lamp2 , Pik3c3 , Rab5a , Rab7a , Vamp3
phosphatidylinositol 3-kinase signaling pathwayPik3c3
phosphoinositide metabolic pathwayBecn1 , Pik3c3 , Pik3r4
platelet-derived growth factor signaling pathwayIfng
potassium channel inhibitors pharmacodynamics pathwayIns2
prostate cancer pathwayIns1 , Ins2
Rab family mediated signaling pathwayRab11a , Rab5a
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayAtg12 , Atg5 , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , LOC100911527
rheumatoid arthritis pathwayIfng
riboflavin metabolic pathwayAcp2
sleeping sickness pathwayIfng
systemic lupus erythematosus pathwayIfng
T cell receptor signaling pathwayIfng
Toll-like receptor signaling pathwayIfna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , LOC100911527
toxoplasmosis pathwayIfng
transforming growth factor-beta superfamily mediated signaling pathwayIfng
tuberculosis pathwayIfna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifng , Lamp1 , Lamp2 , LOC100911527 , Pik3c3 , Rab5a , Rab7a
type 1 diabetes mellitus pathwayIfng , Ins1 , Ins2
type 2 diabetes mellitus pathwayIns1 , Ins2
type II interferon signaling pathwayIfng
ubiquitin/proteasome degradation pathwayIfng
vascular endothelial growth factor signaling pathwayHgs , Prkaa1 , Prkaa2
vasopressin signaling pathwayRab11a
vasopressin signaling pathway via receptor type 2Rab11a , Rab5a
Phenotype Annotations Associated with Genes in the autophagy pathway

References Associated with the autophagy pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio:


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.