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WARFARIN PHARMACODYNAMICS PATHWAY (PW:0000731)

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Description

Warfarin, trade name Coumadin, is a widely used oral anticoagulant drug for the prevention of thrombosis and venous and arterial thromboembolism. It is a synthetic derivative of coumarin-derived dicoumarol. Warfarin is present as a racemic mixture of R and S enantiomers, both active, though not equally, and both metabolized via different routes. Warfarin is metabolized by several cytochrome P450 phase I biotransformation enzymes, depending on the enantiomeric form and producing a number of metab

Pathway Diagram:

Elsevier Inc. Vkorc1 warfarin warfarin ---| Thromboembolism warfarin ---| Thrombosis Vkorc1 ---- warfarin vitamin K cycle pathway warfarin ---| vitamin K cycle pathway warfarin ---| Vkorc1 coagulation cascade pathway warfarin ---| coagulation cascade pathway Thromboembolism Thrombosis
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Genes in Pathway:

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warfarin pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a1 collagen type I alpha 1 chain ISO SMPDB SMP:00268 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G F10 coagulation factor X ISO SMPDB SMP:00268 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716
JBrowse link
G F11 coagulation factor XI ISO SMPDB SMP:00268 NCBI chr16:50,179,458...50,201,644
Ensembl chr16:50,179,458...50,201,698
JBrowse link
G F12 coagulation factor XII ISO SMPDB SMP:00268 NCBI chr17:9,736,577...9,744,420
Ensembl chr17:9,736,577...9,744,420
JBrowse link
G F13a1 coagulation factor XIII A1 chain ISO SMPDB SMP:00268 NCBI chr17:28,504,650...28,680,015
Ensembl chr17:28,504,623...28,680,362
JBrowse link
G F13b coagulation factor XIII B chain ISO SMPDB SMP:00268 NCBI chr13:56,598,891...56,623,132
Ensembl chr13:56,598,957...56,623,124
JBrowse link
G F2 coagulation factor II ISO SMPDB SMP:00268 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G F3 coagulation factor III, tissue factor ISO SMPDB SMP:00268 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G F5 coagulation factor V ISO SMPDB SMP:00268 NCBI chr13:82,479,997...82,535,540
Ensembl chr13:82,479,998...82,535,534
JBrowse link
G F7 coagulation factor VII ISO SMPDB SMP:00268 NCBI chr16:81,824,610...81,834,923
Ensembl chr16:81,824,111...81,834,945
JBrowse link
G F8 coagulation factor VIII ISO SMPDB SMP:00268 NCBI chr18:367,862...399,242
Ensembl chr18:367,862...399,242
JBrowse link
G F9 coagulation factor IX ISO SMPDB SMP:00268 NCBI chr  X:143,097,507...143,141,791
Ensembl chr  X:143,097,525...143,141,794
JBrowse link
G Fga fibrinogen alpha chain ISO SMPDB SMP:00268 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763
JBrowse link
G Fgb fibrinogen beta chain ISO SMPDB SMP:00268 NCBI chr 2:182,028,044...182,035,026
Ensembl chr 2:182,027,115...182,038,178
JBrowse link
G Fgg fibrinogen gamma chain ISO SMPDB SMP:00268 NCBI chr 2:181,987,080...181,994,523
Ensembl chr 2:181,987,217...181,994,514
JBrowse link
G Ggcx gamma-glutamyl carboxylase ISO SMPDB SMP:00268 NCBI chr 4:100,277,345...100,293,097
Ensembl chr 4:100,277,391...100,293,250
JBrowse link
G Klkb1 kallikrein B1 ISO SMPDB SMP:00268 NCBI chr16:50,151,127...50,175,407
Ensembl chr16:50,152,008...50,175,458
JBrowse link
G Plat plasminogen activator, tissue type ISO SMPDB SMP:00268 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Plg plasminogen ISO SMPDB SMP:00268 NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776
JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 ISO SMPDB PMID:26287237 SMP:00268, RGD:11354881 NCBI chr 1:199,338,785...199,341,306
Ensembl chr 1:199,337,138...199,341,302
JBrowse link

Pathway Gene Annotations

Disease Annotations Associated with Genes in the warfarin pharmacodynamics pathway
Disease TermsGene Symbols
1q24 Deletion SyndromeF5
Acquired AngioedemaF12 , F2 , F7
Acute Coronary SyndromeF12 , F2
acute kidney failureFga , Plat , Plg
Acute Liver FailureF5 , Fga
Acute Lung InjuryF2 , F3 , Fga
acute lymphoblastic leukemiaF3 , Fga
acute myeloid leukemiaF3
acute pancreatitisF3 , F7
acute promyelocytic leukemiaF3 , Plat
Acute Traumatic CoagulopathyPlat
adrenoleukodystrophyF8
adult respiratory distress syndromeF3
aggressive periodontitisCol1a1
Airway ObstructionPlat
AlbuminuriaF7
alcoholic hepatitisCol1a1
allergic contact dermatitisF13a1 , Plat
allergic rhinitisF2
Alzheimer's diseaseF2
amphetamine abusePlat
Angina, StableF7
angioedemaF12 , Plat
Animal Disease ModelsF7
anterior segment dysgenesisCol1a1
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisF3
antiphospholipid syndromePlat
aortic aneurysmCol1a1
Aortic CalcificationVkorc1
Aortic CoarctationCol1a1
Aortic RuptureVkorc1
aortic valve insufficiencyCol1a1
aphasiaPlat
appendicitisF2
ARTERIAL DISSECTIONCol1a1
Arterial Occlusive DiseasesPlat
Arterial ThrombosisF7 , Plat
arteriosclerosisF13a1 , F7
Arteriovenous FistulaCol1a1
asthmaF2 , F7 , Fga
atherosclerosisF2 , Plat
atopic dermatitisF2
atrial heart septal defectCol1a1
attention deficit hyperactivity disorderCol1a1
autism spectrum disorderKlkb1
autistic disorderCol1a1 , F11 , F8 , F9 , Klkb1
autoimmune diseaseCol1a1 , F8
autoimmune hepatitisF2
autoimmune thrombocytopenic purpuraPlat
autosomal hemophilia AF8
B-lymphoblastic leukemia/lymphomaF13a1 , F3
Back PainPlat
BacteremiaPlat
bacterial pneumoniaF2
Behcet's diseaseF5
beta thalassemiaCol1a1
bile duct diseaseF3
bilirubin metabolic disorderF12 , F7
Bisphosphonate-Associated Osteonecrosis of the JawCol1a1
bladder neck obstructionCol1a1
blood coagulation diseaseF10 , F2 , F5 , F7 , F8 , F9 , Fgg , Ggcx , Plat , Vkorc1
bone development diseaseCol1a1
Bone FracturesCol1a1
brain edemaF2 , Plat
brain infarctionPlat
Brain InjuriesF2
brain ischemiaF2 , F5 , Fga , Plat
branched-chain keto acid dehydrogenase kinase deficiencyVkorc1
breast cancerF10 , F5 , F7
Breast NeoplasmsF3
Budd-Chiari syndromeF5 , F7
bullous pemphigoidF2
BurnsFga , Plat
C1 inhibitor deficiencyF12
Cafe-au-Lait SpotsCol1a1
Caffey diseaseCol1a1
calcinosisCol1a1
calcium oxalate nephrolithiasisF2
capillary hemangiomaCol1a1
Cardiac Allograft VasculopathyF3
Cardiac ArrhythmiasCol1a1
Cardiac FibrosisCol1a1 , F3
cardiac tamponadePlat
Cardiogenic ShockPlat
cardiomyopathyCol1a1
cardiovascular system diseaseFgb
carotid artery diseaseFgb
Carotid Artery InjuriesPlat
carotid artery thrombosisF3 , Klkb1
carotid stenosisF2
cataractCol1a1
celiac diseaseF2
central nervous system diseaseCol1a1
Central Nervous System Viral DiseasesPlat
cerebellar ataxiaCol1a1
Cerebral HemorrhageF13a1 , F2 , F7 , Plat
cerebral infarctionF2 , F5 , F7 , Plat
Cerebral Small Vessel DiseasesFga , Fgg
Chagas diseaseF2
Chemical and Drug Induced Liver InjuryF13a1 , F3 , Fga , Plat , Plg
cholangitisCol1a1
cholestasisCol1a1 , Fga
cholesterol embolismPlat
choreatic diseaseCol1a1
Choroidal NeovascularizationF7
Chronic Allograft DysfunctionF7
Chronic HepatitisPlat
chronic obstructive pulmonary diseaseCol1a1 , F2
Chronic PancreatitisCol1a1
clear cell renal cell carcinomaF2
cleft lipCol1a1
cleft palateCol1a1
clubfootCol1a1
Coagulation Protein DisordersGgcx
colobomaCol1a1
colon adenomaF5
Colonic NeoplasmsF5
colorectal cancerF7
Colorectal NeoplasmsF7
Complete Atrioventricular Septal DefectCol1a1
Conductive Hearing LossCol1a1
congenital afibrinogenemiaFga , Fgb , Fgg
congenital diaphragmatic herniaCol1a1
Congenital Hand DeformitiesCol1a1
Congenital HypodysfibrinogenemiaFga , Fgb , Fgg
Congenital Prothrombin DeficiencyF2
congestive heart failurePlat
conjunctivitisPlg
connective tissue diseaseCol1a1
ContractureCol1a1
ContusionsF2
coronary artery diseaseF2 , F7 , Fgb
Coronary DiseaseF12 , F13a1 , Vkorc1
coronary thrombosisPlat
Coumarin SensitivityVkorc1
COVID-19F2 , F3 , F5 , Plg
craniosynostosisCol1a1
Crohn's diseaseF13a1 , F2 , Fga
cryptorchidismCol1a1
cutaneous leishmaniasisCol1a1
cystic fibrosisPlg
cystic kidney diseaseCol1a1
DeathF12
degenerative disc diseaseCol1a1
dentinogenesis imperfectaCol1a1
dermatofibrosarcoma protuberansCol1a1
Developmental DisabilitiesCol1a1
diabetes mellitusCol1a1 , F3 , F7
Diabetes Mellitus, Experimental F2 , F3 , F7 , Fga
diabetic angiopathyF3 , Plat
Diabetic FootPlat
Diabetic NephropathiesCol1a1 , F2 , F3 , Klkb1 , Plat
diabetic neuropathyF7 , Plat
diabetic retinopathyF13a1 , F3 , F7
Diaphragmatic HerniaCol1a1
disorders of sexual developmentCol1a1
Dissecting AneurysmCol1a1
disseminated intravascular coagulationF13a1 , F2 , F3 , F7 , Fga , Plat
Drug-Related Side Effects and Adverse ReactionsFga , Plg , Vkorc1
DwarfismCol1a1
DysarthriaF5
Dysfibrinogenemia, CongenitalFga , Fgb , Fgg
DyspneaF5
DysprothrombinemiaF2
dystoniaCol1a1
Ehlers-Danlos syndromeCol1a1
Ehlers-Danlos syndrome arthrochalasia type 1Col1a1
Ehlers-Danlos syndrome arthrochalasia type 2Col1a1
Ehlers-Danlos syndrome cardiac valvular typeCol1a1
Ehlers-Danlos syndrome classic type 1Col1a1
Ehlers-Danlos syndrome classic type 2Col1a1
Ehlers-Danlos Syndrome Type 7Col1a1
EmbolismPlat
Embolism and ThrombosisF3 , Plat
end stage renal diseaseCol1a1 , F2 , F5 , Fgb
EndotoxemiaF12 , F2 , F3 , F5 , F7 , F8 , Fga , Plat
EnterocolitisKlkb1
epilepsyCol1a1
esophageal atresiaCol1a1
esophageal atresia/tracheoesophageal fistulaCol1a1
exocrine pancreatic insufficiencyCol1a1
Experimental ArthritisF2 , Klkb1
Experimental Liver CirrhosisCol1a1 , F5 , Fgg , Plat , Plg
Experimental Liver NeoplasmsF12
extrahepatic cholestasisCol1a1
Extrahepatic Portal Vein ObstructionF7
eye diseaseF2
factor V deficiencyF5
factor VII deficiencyF10 , F7
factor VIII deficiencyF2 , F8 , F9 , Plat
Factor VIII Deficiency, AcquiredF8
factor X deficiencyF10 , F11 , F7
factor XI deficiencyF11 , Klkb1
factor XII deficiencyF12
factor XIII deficiencyF13a1 , F13b
Factor Xiii, A Subunit, Deficiency OfF13a1
Factor XIII, B Subunit, Deficiency OfF13b
Failure to ThriveCol1a1
familial adenomatous polyposisF5
Familial Amyloid PolyneuropathiesF10 , F2
Familial AmyloidosisFga
familial hyperlipidemiaF3 , F7
familial visceral amyloidosisFga
fatty liver diseaseF2
Femoral FracturesCol1a1
Femur Head NecrosisF2 , F5 , Plat
Fetal DeathF5
FibrosisCol1a1
Fractures, MultipleCol1a1
Funnel ChestCol1a1
Fused KidneyCol1a1
gastric ulcerF13a1
gastroschisisCol1a1
genetic diseaseCol1a1 , F8 , F9 , Fgg
gestational diabetesPlat
Glandular and Epithelial NeoplasmsF7
glomerulonephritisF2 , Klkb1
Graft vs Host DiseaseF3
Habitual AbortionsF5
heart valve diseaseCol1a1
Hematoma, Epidural, SpinalPlat
Hematoma, Subdural, AcuteF7
HematuriaF7
hemolytic-uremic syndromePlat
hemophilia BF2 , F8 , F9
HemorrhageF10 , F13a1 , F2 , F3 , F7 , F8 , Plat , Vkorc1
hemorrhagic diseaseCol1a1 , F10 , F11 , F5 , F7 , F8 , Fga , Fgb , Fgg , Ggcx
Hemorrhagic ShockF2 , F8
Henoch-Schoenlein purpuraPlat
hepatic veno-occlusive diseaseF7
hepatitisF5
hepatocellular carcinomaF2
hereditary angioedemaF12 , F2 , F7 , Plg
Hereditary Angioedema Type IIIF12
Hereditary Angioedema Types I and IIF12 , Plg
Hereditary ThrombophiliaF5
Hernia, VentralCol1a1
High MyopiaCol1a1
Hirschsprung's diseaseCol1a1 , F5
Human Viral HepatitisCol1a1 , F2
Huntington's diseaseF2
HyperalgesiaF2
hypereosinophilic syndromeF5
hyperglycemiaF2 , F7
hyperhomocysteinemiaF10 , F12 , F2 , F8
HypertelorismCol1a1
hypertensionCol1a1 , F11 , F12 , F3 , F7 , Klkb1 , Plat , Plg
Hypertensive NephropathyCol1a1
HypertriglyceridemiaF7
HypertrophyF2
hypophosphatemic nephrolithiasis/osteoporosisF12
hypophosphatemic nephrolithiasis/osteoporosis 1F12
hypospadiasCol1a1
HypotensionPlat
hypothyroidismF7
HypoxiaPlat
Hypoxia-Ischemia, BrainPlat
idiopathic pulmonary fibrosisF3
InflammationF3 , Fgg
inflammatory bowel diseaseKlkb1
Inherited Blood Coagulation DiseaseF7 , Ggcx
Insulin ResistanceF7
intellectual disabilityCol1a1
intermediate coronary syndromeF7
Intervertebral Disc DiseaseCol1a1
Intestinal Reperfusion InjuryF7
Intracranial Embolism and ThrombosisPlat
Intracranial Hemorrhage, TraumaticF7
Intracranial HemorrhagesF7 , Plat
intracranial sinus thrombosisF2
intracranial thrombosisPlat
intracranial vasospasmPlat
Joint InstabilityCol1a1
KeloidCol1a1 , Fgg
keratoconusFga
Kidney CalculiF2
kidney diseaseF7 , Fga
Kidney Reperfusion InjuryF3 , Fga , Fgb , Fgg
Knee OsteoarthritisF2
lactic acidosisPlat
Language Development DisordersCol1a1
learning disabilityCol1a1
Left Ventricular HypertrophyCol1a1
leukocyte diseasePlg
LeukoencephalopathiesPlg
leukopeniaPlat
LipodermatosclerosisCol1a1
liver benign neoplasmCol1a1
liver cirrhosisCol1a1 , F2 , F3 , F5 , Klkb1
Liver FailureF2
Liver InjuryF3 , Fgg
Liver Reperfusion InjuryF3 , Fga
Low Back PainPlat
lupus nephritisCol1a1 , Klkb1
MacrocephalyCol1a1
malignant gliomaF2
malignant mesotheliomaF9
Marfanoid Mental Retardation Syndrome, AutosomalF12
megacolonCol1a1
membranoproliferative glomerulonephritisF5
membranous glomerulonephritisPlg
meningoencephalitisPlat
Mesenteric IschemiaF2 , F5
Metabolic Bone DiseasesCol1a1
Metabolic SyndromeF3 , Plat
microcephalyCol1a1 , F8
microphthalmiaCol1a1
middle cerebral artery infarctionF11 , F12 , F2 , Plat
Mouth NeoplasmsFga
multiple myelomaFgg
Multiple Organ FailurePlat
multiple sclerosisCol1a1
Muscle HypotoniaCol1a1
Muscle SpasticityCol1a1
myeloid neoplasmF3
myocardial infarctionCol1a1 , F10 , F12 , F13a1 , F2 , F3 , F5 , F7 , Fgb , Plat
Myocardial IschemiaF3 , F5
myocarditisCol1a1
myopiaCol1a1
NeointimaF3
Neoplasm MetastasisF2
Nephrogenic Fibrosing DermopathyCol1a1
nephrosclerosisCol1a1
nephrosisF2
nephrotic syndromeCol1a1 , F3
Nerve DegenerationF2 , Plat
Neurologic ManifestationsPlat
non-alcoholic fatty liver diseaseCol1a1 , F2
non-arteritic anterior ischemic optic neuropathyF5
Noonan syndromeF11 , Plat , Plg
obesityF2 , F7 , Fgg , Plat
ocular hypertensionCol1a1
OI/EDS Combined SyndromeCol1a1
omphaloceleCol1a1
open-angle glaucomaCol1a1
oral submucous fibrosisCol1a1
osteoarthritisCol1a1
Osteoarthritis, ExperimentalCol1a1
Osteoarthritis, HipCol1a1
osteogenesis imperfectaCol1a1
osteogenesis imperfecta type 1Col1a1
osteogenesis imperfecta type 2Col1a1
osteogenesis imperfecta type 2CCol1a1
osteogenesis imperfecta type 3Col1a1
osteogenesis imperfecta type 4Col1a1
osteonecrosisPlg
osteoporosisCol1a1 , Fga , Fgb
otitis mediaPlg
otosclerosisCol1a1
ovarian cancerF2 , F7
ovarian hyperstimulation syndromeF3
Ovary Reperfusion InjuryF3
pancreatic adenocarcinomaPlat
pancreatitisFga , Fgb , Fgg
ParatuberculosisF2
ParesisPlat
Parkinson's diseaseFgb
pathologic nystagmusCol1a1
Pediatric Crohn's DiseaseF2
pericardial effusionPlat
Peritoneal FibrosisF10 , F3 , F5
peritonitisPlat
plasminogen deficiency type IPlg
portal hypertensionF5
portal vein thrombosisF2
Postaxial PolydactylyCol1a1
Postmenopausal OsteoporosisCol1a1
Postoperative ComplicationsF7
pre-eclampsiaF2 , F3 , F5
Preaxial PolydactylyCol1a1
Prekallikrein DeficiencyKlkb1
preterm premature rupture of the membranesF3
priapismF13a1
primary biliary cholangitisCol1a1
prostate cancerCol1a1 , F2 , F5
proteinuriaF7
prothrombin deficiencyF2 , F7
Pseudoxanthoma Elasticum-Like Disorder with Multiple Coagulation Factor DeficiencyGgcx
pulmonary embolismF13a1 , F2 , F5 , Fga , Fgb , Fgg , Klkb1 , Plat
pulmonary emphysemaFga
pulmonary fibrosisCol1a1 , F2 , F5
pulmonary hypertensionCol1a1 , F5
Reperfusion InjuryF2 , Plat
respiratory failurePlat
retinal artery occlusionF5
retinal diseaseCol1a1
retinal vein occlusionF2 , F5
rheumatoid arthritisF2
Right Ventricular HypertrophyPlat
sagittal sinus thrombosisF5
schizophreniaF2
sciatic neuropathyPlat
scoliosisCol1a1
Seasonal Allergic RhinitisFga
sensorineural hearing lossCol1a1 , F2 , F5
SepsisF11 , F2 , F3 , F5 , F7 , F9 , Fga , Klkb1 , Plat
Septic PeritonitisF5
severe acute respiratory syndromeFgb , Fgg , Plat , Plg
sickle cell anemiaF2 , F3
Smoke Inhalation InjuryF7
Snake BitesF3
spina bifidaCol1a1
Spinal Cord CompressionPlat
Spinal Cord InjuriesF2
Spontaneous AbortionsCol1a1 , F11 , F12 , F13a1 , F2 , F3 , F5
status epilepticusPlat
Stomach NeoplasmsFgg
strabismusCol1a1
StrokeF12 , F13a1 , F2 , F5 , F8 , Fga , Fgb , Fgg , Plat , Vkorc1
Subdural HematomaPlat
syndromic X-linked intellectual disability Lubs typeF9
Systemic Inflammatory Response SyndromeF3
systemic lupus erythematosusF2 , Klkb1
systemic sclerodermaCol1a1 , F2
Tendon InjuriesCol1a1
tetralogy of FallotCol1a1
thoracic aortic aneurysmCol1a1
thrombocytopeniaF7 , Fga
ThromboembolismF12 , F2 , F3 , F5 , F7 , F8 , Fgg , Plat
thrombophiliaF13a1 , F2 , F3 , F8 , Fga , Plg
thrombophilia due to activated protein C resistanceF5
thrombophilia due to decreased release of PLATPlat
thrombophilia due to thrombin defectF13a1 , F2
thrombosisF10 , F11 , F2 , F3 , F5 , F9 , Fga , Fgb , Klkb1 , Plat , Vkorc1
Thrombotic MicroangiopathiesF3 , Fgg
thrombotic thrombocytopenic purpuraF3
toxic encephalopathyPlat
Tracheoesophageal FistulaCol1a1
Trachomatous TrichiasisCol1a1
transient cerebral ischemiaF12 , Plat
Transplant RejectionPlat
type 1 diabetes mellitusCol1a1 , F7 , Plat
type 2 diabetes mellitusF12 , F2 , F3 , F7 , F8 , F9 , Fga , Fgb , Fgg , Plat
ulcerative colitisCol1a1 , F2
ureteral obstructionCol1a1
urinary bladder cancerF2
Urinary CalculiF2
urolithiasisGgcx
urticariaF12 , F2
Uterine HemorrhageF13a1
vascular diseaseVkorc1
vascular skin diseaseF2
Venous ThromboembolismF2 , F5 , Fga , Plat
Venous ThrombosisF11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , Fga , Fgb , Plat , Plg
Ventricular Dysfunction, LeftF2 , Plat
Ventricular FibrillationF2
ventricular septal defectCol1a1
Viral MyocarditisF3
Vision DisordersCol1a1 , F8
visual epilepsyCol1a1
vitamin K deficiency bleedingGgcx
Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, 1Ggcx
Vitamin K-Dependent Clotting Factors, Combined Deficiency of, 2Vkorc1
von Willebrand's diseaseF3
von Willebrand's disease 1Plat
von Willebrand's disease 2F8
warfarin resistanceVkorc1
warfarin sensitivityF9 , Vkorc1
Wounds and InjuriesPlat
X-linked thrombophilia due to factor IX defectF9
Pathway Annotations Associated with Genes in the warfarin pharmacodynamics pathway
Pathway TermsGene Symbols
acenocoumarol pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
alteplase pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
aminocaproic acid pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
anistreplase pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
aprotinin pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
argatroban pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
bivalirudin pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
cell-extracellular matrix signaling pathwayCol1a1
coagulation cascade pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
complement system pathwayF10 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
dicoumarol pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
enoxaparin pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
Entamoebiasis pathwayCol1a1
ephrin - ephrin receptor bidirectional signaling axisFga , Fgb , Fgg
fibrinolysis pathwayFga , Fgb , Fgg , Plat , Plg
fondaparinux pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
forkhead class A signaling pathwayF2
heparin pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
influenza A pathwayPlg
interleukin-4 signaling pathwayCol1a1
interleukin-6 signaling pathwayFgg
kallikrein-kinin cascade pathwayF12 , Klkb1
phenindione pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
protease mediated signaling via protease-activated receptor 1F2
protease mediated signaling via protease-activated receptor 2F10
protease mediated signaling via protease-activated receptor 3F2
protease mediated signaling via protease-activated receptor 4F2
protein C anticoagulant pathwayF2 , F5
reteplase pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
Staphylococcus aureus infection pathwayFgg , Plg
syndecan signaling pathwayCol1a1 , F2 , Plg
tranexamic acid pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
vitamin K cycle pathwayGgcx , Vkorc1
vitamin K metabolic pathwayF2 , Ggcx , Vkorc1
warfarin pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
Phenotype Annotations Associated with Genes in the warfarin pharmacodynamics pathway

References Associated with the warfarin pharmacodynamics pathway:

Ontology Path Diagram:

paths to the root
paths to the root

Import into Pathway Studio:


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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.