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# of AnimalsPhenotypeStrainSexValueUnitsConditionsRecord IDCondition 1aCondition 1bCondition 2aCondition 2bCondition 3aCondition 3bCondition 4Condition 5Condition 6
42systolic blood pressureBN/NHsdMcwimale127mmHgcontrolled sodium content diet (0.1 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) and controlled exposure to ambient light (for 12 hours)12006controlled sodium content diet (0.1 %) (for 28 days)controlled sodium content diet (8 %) (for 31 days)controlled exposure to ambient light (for 12 hours)
42diastolic blood pressureBN/NHsdMcwimale94mmHgcontrolled sodium content diet (0.1 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) and controlled exposure to ambient light (for 12 hours)12009controlled sodium content diet (0.1 %) (for 28 days)controlled sodium content diet (8 %) (for 31 days)controlled exposure to ambient light (for 12 hours)
42mean arterial blood pressureBN/NHsdMcwimale109mmHgcontrolled sodium content diet (0.1 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) and controlled exposure to ambient light (for 12 hours)12012controlled sodium content diet (0.1 %) (for 28 days)controlled sodium content diet (8 %) (for 31 days)controlled exposure to ambient light (for 12 hours)
42mean arterial blood pressureBN/NHsdMcwimale114mmHgcontrolled sodium content diet (0.1 %) (for 28 days) then controlled sodium content diet (8 %) (for 30 days) and controlled exposure to darkness (for 12 hours)12016controlled sodium content diet (0.1 %) (for 28 days)controlled sodium content diet (8 %) (for 30 days)controlled exposure to darkness (for 12 hours)
21mean arterial blood pressureBN/NHsdMcwimale96mmHgcontrolled sodium content diet (0.4 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 1.5 days) then controlled exposure to ambient light (for 12 hours)13275controlled sodium content diet (0.4 %) (for 28 days)controlled sodium content diet (8 %) (for 31 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 1.5 days)controlled exposure to ambient light (for 12 hours)
42absolute change in mean arterial blood pressureBN/NHsdMcwimale4.5mmHgcontrolled sodium content diet (0.4 %) (for 28 days) then controlled sodium content diet (8 %) (for 30 days) then controlled exposure to ambient light (for 12 hours) then controlled exposure to darkness (for 12 hours)64928controlled sodium content diet (0.4 %) (for 28 days)controlled sodium content diet (8 %) (for 30 days)controlled exposure to ambient light (for 12 hours)controlled exposure to darkness (for 12 hours)
42mean arterial blood pressureBN/NHsdMcwimale109mmHgcontrolled sodium content diet (0.4 %) (for 28 days) then controlled sodium content diet (8 %) (for 30 days) and controlled exposure to ambient light (for 12 hours)66139controlled sodium content diet (0.4 %) (for 28 days)controlled sodium content diet (8 %) (for 30 days)controlled exposure to ambient light (for 12 hours)
10creatinine clearanceBN/NHsdMcwifemale1.7ml/mincontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)67283controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
8creatinine clearanceBN/NHsdMcwifemale1.1ml/mincontrolled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) 69479controlled sodium content diet (0.4 %) (for 16 hours)furosemide (10 mg/kg)
9plasma high density lipoprotein cholesterol levelBN/NHsdMcwifemale44.2mg/dlcontrolled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) 69503controlled sodium content diet (0.4 %) (for 16 hours)furosemide (10 mg/kg)
13white blood cell countBN/NHsdMcwifemale0.0157x 1000 cells/ulcontrolled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) 69495controlled sodium content diet (0.4 %) (for 16 hours)furosemide (10 mg/kg)
13plasma total protein levelBN/NHsdMcwifemale38.6mg/mlcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)69483controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
15hematocritBN/NHsdMcwifemale41.6%controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)69481controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
22urine potassium levelBN/NHsdMcwifemale93.4mmol/lcontrolled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) 69471controlled sodium content diet (0.4 %) (for 16 hours)furosemide (10 mg/kg)
22urine potassium excretion rateBN/NHsdMcwifemale0.8784mEq/dcontrolled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) 69473controlled sodium content diet (0.4 %) (for 16 hours)furosemide (10 mg/kg)
24urine potassium excretion rateBN/NHsdMcwifemale0.9648mEq/dcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)69461controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
23urine creatinine excretion rateBN/NHsdMcwifemale0.0047916636mg/dcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)69462controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
25urine creatinine levelBN/NHsdMcwifemale56.4mg/dlcontrolled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) 69475controlled sodium content diet (0.4 %) (for 16 hours)furosemide (10 mg/kg)
25urine creatinine excretion rateBN/NHsdMcwifemale0mg/dcontrolled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) 69477controlled sodium content diet (0.4 %) (for 16 hours)furosemide (10 mg/kg)
24urine creatinine levelBN/NHsdMcwifemale30.2mg/dlcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)69455controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
22urine sodium levelBN/NHsdMcwifemale100.4mmol/lcontrolled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) 69466controlled sodium content diet (0.4 %) (for 16 hours)furosemide (10 mg/kg)
22urine sodium excretion rateBN/NHsdMcwifemale0.45833304mEq/dcontrolled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) 69468controlled sodium content diet (0.4 %) (for 16 hours)furosemide (10 mg/kg)
24urine sodium levelBN/NHsdMcwifemale370mmol/lcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)69453controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
24urine sodium excretion rateBN/NHsdMcwifemale6.3541626mEq/dcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)69459controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
25timed urine volumeBN/NHsdMcwifemale9.86ml/dcontrolled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) 69464controlled sodium content diet (0.4 %) (for 16 hours)furosemide (10 mg/kg)
25timed urine volumeBN/NHsdMcwifemale35ml/dcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)69451controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
11plasma creatinine levelBN/NHsdMcwifemale0.4mg/dlcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)66153controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
8plasma creatinine levelBN/NHsdMcwifemale0.42mg/dlcontrolled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) 69485controlled sodium content diet (0.4 %) (for 16 hours)furosemide (10 mg/kg)
20urine total protein excretion rateBN/NHsdMcwifemale8.6mg/dcontrolled sodium content diet (0.4 %) (for 35 days)66151controlled sodium content diet (0.4 %) (for 35 days)
20urine total protein levelBN/NHsdMcwifemale0.24mg/mlcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (0.4 %) (between 22 and 24 days)69457controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (0.4 %) (between 22 and 24 days)
22heart left ventricle wet weightBN/NHsdMcwifemale0.45gcontrolled sodium content diet (0.4 %) (for 35 days)67297controlled sodium content diet (0.4 %) (for 35 days)
27heart wet weightBN/NHsdMcwifemale0.69gcontrolled sodium content diet (0.4 %) (for 35 days)67295controlled sodium content diet (0.4 %) (for 35 days)
33body weightBN/NHsdMcwifemale175gcontrolled sodium content diet (0.4 %) 67293controlled sodium content diet (0.4 %)
24body weightBN/NHsdMcwifemale168gcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) and controlled sodium content diet (8 %) (between 22 and 24 days)69439controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
33body weightBN/NHsdMcwifemale167gcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) and controlled sodium content diet (8 %) (between 22 and 24 days)69441controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
7plasma triglyceride levelBN/NHsdMcwifemale0.7232mmol/lcontrolled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) 67291controlled sodium content diet (0.4 %) (for 16 hours)furosemide (10 mg/kg)
10plasma total cholesterol levelBN/NHsdMcwifemale56mg/dlcontrolled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) 67289controlled sodium content diet (0.4 %) (for 16 hours)furosemide (10 mg/kg)
26single kidney wet weight to body weight ratioBN/NHsdMcwifemale5g/kgcontrolled sodium content diet (0.4 %) (for 35 days)67287controlled sodium content diet (0.4 %) (for 35 days)
27left kidney wet weightBN/NHsdMcwifemale0.86gcontrolled sodium content diet (0.4 %) (for 35 days)69505controlled sodium content diet (0.4 %) (for 35 days)
27right kidney wet weightBN/NHsdMcwifemale0.76gcontrolled sodium content diet (0.4 %) (for 35 days)69507controlled sodium content diet (0.4 %) (for 35 days)
22kidney glomerulus diameterBN/NHsdMcwifemale95umcontrolled sodium content diet (0.4 %) (for 35 days)67285controlled sodium content diet (0.4 %) (for 35 days)
21ratio of change in renal blood flow rate to kidney weightBN/NHsdMcwifemale-1.4ml/min/gcontrolled sodium content diet (0.4 %) (for 16 hours) then angiotensin II (200 ng/kg/min) (for 0.1 hours)67305controlled sodium content diet (0.4 %) (for 16 hours)angiotensin II (200 ng/kg/min) (for 0.1 hours)
19ratio of change in renal blood flow rate to kidney weightBN/NHsdMcwifemale-1.4ml/min/gcontrolled sodium content diet (0.4 %) (for 16 hours) then norepinephrine (3 ug/kg/min) (for 0.1 hours)67307controlled sodium content diet (0.4 %) (for 16 hours)norepinephrine (3 ug/kg/min) (for 0.1 hours)
20ratio of change in renal blood flow rate to kidney weightBN/NHsdMcwifemale-1.2ml/min/gcontrolled sodium content diet (0.4 %) (for 16 hours) then NG-nitroarginine methyl ester (5 mg/kg) 67309controlled sodium content diet (0.4 %) (for 16 hours)NG-nitroarginine methyl ester (5 mg/kg)
11plasma renin activity levelBN/NHsdMcwifemale9.6ng/ml/hcontrolled sodium content diet (0.4 %) (for 35 days) and furosemide (10 mg/kg) 65474controlled sodium content diet (0.4 %) (for 35 days)furosemide (10 mg/kg)
14plasma renin activity levelBN/NHsdMcwifemale1.4ng/ml/hcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)13308controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
14heart rateBN/NHsdMcwifemale395beats/mincontrolled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) 65468controlled sodium content diet (0.4 %) (for 16 hours)furosemide (10 mg/kg)
20heart rateBN/NHsdMcwifemale367beats/mincontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (for 21 days)13309controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (for 21 days)
21heart rateBN/NHsdMcwifemale386.5beats/mincontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)69513controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
20heart rateBN/NHsdMcwifemale369.9beats/mincontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)69519controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
16heart rateBN/NHsdMcwifemale370.1beats/mincontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)69525controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
18heart rateBN/NHsdMcwifemale386beats/mincontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) then controlled exposure to darkness (for 12 hours)69449controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)controlled exposure to darkness (for 12 hours)
21systolic blood pressureBN/NHsdMcwifemale130mmHgcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)11849controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
21diastolic blood pressureBN/NHsdMcwifemale92mmHgcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)11851controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
21mean arterial blood pressureBN/NHsdMcwifemale110mmHgcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)11853controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
14systolic blood pressureBN/NHsdMcwifemale110mmHgcontrolled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) 65462controlled sodium content diet (0.4 %) (for 16 hours)furosemide (10 mg/kg)
14diastolic blood pressureBN/NHsdMcwifemale72mmHgcontrolled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) 65464controlled sodium content diet (0.4 %) (for 16 hours)furosemide (10 mg/kg)
14mean arterial blood pressureBN/NHsdMcwifemale89mmHgcontrolled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) 65466controlled sodium content diet (0.4 %) (for 16 hours)furosemide (10 mg/kg)
20absolute change in mean arterial blood pressureBN/NHsdMcwifemale27mmHgfurosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (200 ng/kg/min) (for 0.1 hours)67299furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 7 days)angiotensin II (200 ng/kg/min) (for 0.1 hours)
19absolute change in mean arterial blood pressureBN/NHsdMcwifemale22mmHgfurosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (3 ug/kg/min) (for 0.1 hours)67301furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 7 days)norepinephrine (3 ug/kg/min) (for 0.1 hours)
20absolute change in mean arterial blood pressureBN/NHsdMcwifemale25mmHgfurosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) 67303furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 7 days)NG-nitroarginine methyl ester (5 mg/kg)
14absolute change in mean arterial blood pressureBN/NHsdMcwifemale16mmHgcontrolled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) then tactile electric shock exposure (2 %) 66149controlled sodium content diet (0.4 %) (for 16 hours)furosemide (10 mg/kg) tactile electric shock exposure (2 %)
20systolic blood pressureBN/NHsdMcwifemale140.6mmHgcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)69509controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
20diastolic blood pressureBN/NHsdMcwifemale103.2mmHgcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)69511controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
21systolic blood pressureBN/NHsdMcwifemale127.2mmHgcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)69515controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
21diastolic blood pressureBN/NHsdMcwifemale89.6mmHgcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)69517controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
17systolic blood pressureBN/NHsdMcwifemale134.6mmHgcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)69521controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
17diastolic blood pressureBN/NHsdMcwifemale91.6mmHgcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days)69523controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)
20systolic blood pressureBN/NHsdMcwifemale130mmHgcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) then controlled exposure to darkness (for 12 hours)69443controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)controlled exposure to darkness (for 12 hours)
20diastolic blood pressureBN/NHsdMcwifemale96mmHgcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) then controlled exposure to darkness (for 12 hours)69445controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)controlled exposure to darkness (for 12 hours)
20mean arterial blood pressureBN/NHsdMcwifemale111mmHgcontrolled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) then controlled exposure to darkness (for 12 hours)69447controlled sodium content diet (0.4 %) (for 35 days)controlled sodium content diet (0.1 %) (for 35 days)controlled sodium content diet (8 %) (between 22 and 24 days)controlled exposure to darkness (for 12 hours)
21mean arterial blood pressureBN/NHsdMcwifemale111.8mmHgfurosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days)69527furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 7 days)
20mean arterial blood pressureBN/NHsdMcwifemale118.9mmHgfurosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (20 ng/kg/min) (for 0.1 hours)69529furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 7 days)angiotensin II (20 ng/kg/min) (for 0.1 hours)
21mean arterial blood pressureBN/NHsdMcwifemale132.9mmHgfurosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (100 ng/kg/min) (for 0.1 hours)69531furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 7 days)angiotensin II (100 ng/kg/min) (for 0.1 hours)
21mean arterial blood pressureBN/NHsdMcwifemale139.1mmHgfurosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (200 ng/kg/min) (for 0.1 hours)69533furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 7 days)angiotensin II (200 ng/kg/min) (for 0.1 hours)
21mean arterial blood pressureBN/NHsdMcwifemale120.4mmHgfurosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (0.5 ug/kg/min) (for 0.1 hours)69535furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 7 days)norepinephrine (0.5 ug/kg/min) (for 0.1 hours)
21mean arterial blood pressureBN/NHsdMcwifemale128.6mmHgfurosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (1 ug/kg/min) (for 0.1 hours)69537furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 7 days)norepinephrine (1 ug/kg/min) (for 0.1 hours)
20mean arterial blood pressureBN/NHsdMcwifemale135.6mmHgfurosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (3 ug/kg/min) (for 0.1 hours)69539furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 7 days)norepinephrine (3 ug/kg/min) (for 0.1 hours)
21mean arterial blood pressureBN/NHsdMcwifemale111.3mmHgfurosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then acetylcholine (0.1 ug/kg/min) (for 0.1 hours)69541furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 7 days)acetylcholine (0.1 ug/kg/min) (for 0.1 hours)
16mean arterial blood pressureBN/NHsdMcwifemale118.6mmHgfurosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then acetylcholine (0.2 ug/kg/min) (for 0.1 hours)69543furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 7 days)acetylcholine (0.2 ug/kg/min) (for 0.1 hours)
21mean arterial blood pressureBN/NHsdMcwifemale137.4mmHgfurosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) 69545furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 7 days)NG-nitroarginine methyl ester (5 mg/kg)
21mean arterial blood pressureBN/NHsdMcwifemale138.6mmHgfurosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) then acetylcholine (0.1 ug/kg/min) (for 0.1 hours)69547furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 7 days)NG-nitroarginine methyl ester (5 mg/kg) acetylcholine (0.1 ug/kg/min) (for 0.1 hours)
17mean arterial blood pressureBN/NHsdMcwifemale144.9mmHgfurosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) then acetylcholine (0.2 ug/kg/min) (for 0.1 hours)69549furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 7 days)NG-nitroarginine methyl ester (5 mg/kg) acetylcholine (0.2 ug/kg/min) (for 0.1 hours)
18total white blood cell countBN/NHsdMcwimale6.5389x 1000 cells/ulnaive control condition (for 14 days)39956naive control condition (for 14 days)
11total white blood cell countBN/NHsdMcwifemale5.5182x 1000 cells/ulnaive control condition (for 14 days)39957naive control condition (for 14 days)
15mean corpuscular hemoglobin concentrationBN/NHsdMcwimale32.2733g/dlair oxygen content (12 %) (for 14 days)39855air oxygen content (12 %) (for 14 days)
13mean corpuscular hemoglobin concentrationBN/NHsdMcwifemale32.1692g/dlair oxygen content (12 %) (for 14 days)39856air oxygen content (12 %) (for 14 days)
15blood monocyte countBN/NHsdMcwimale0.18x 1000 cells/ulair oxygen content (12 %) (for 14 days)39752air oxygen content (12 %) (for 14 days)
12blood monocyte countBN/NHsdMcwifemale0.0833x 1000 cells/ulair oxygen content (12 %) (for 14 days)39753air oxygen content (12 %) (for 14 days)
20plasma creatinine levelBN/NHsdMcwimale0.24mg/dlair oxygen content (12 %) (for 14 days)39654air oxygen content (12 %) (for 14 days)
17plasma creatinine levelBN/NHsdMcwifemale0.2529mg/dlair oxygen content (12 %) (for 14 days)39655air oxygen content (12 %) (for 14 days)
20serum sodium levelBN/NHsdMcwimale144.75mmol/lair oxygen content (12 %) (for 14 days)39466air oxygen content (12 %) (for 14 days)
17serum sodium levelBN/NHsdMcwifemale143.8235mmol/lair oxygen content (12 %) (for 14 days)39467air oxygen content (12 %) (for 14 days)
15red blood cell countBN/NHsdMcwimale9.3587x 10E6 cells/ulair oxygen content (12 %) (for 14 days)39315air oxygen content (12 %) (for 14 days)
13red blood cell countBN/NHsdMcwifemale9.5362x 10E6 cells/ulair oxygen content (12 %) (for 14 days)39316air oxygen content (12 %) (for 14 days)
20serum chloride levelBN/NHsdMcwimale110.25mmol/lair oxygen content (12 %) (for 14 days)39195air oxygen content (12 %) (for 14 days)
17serum chloride levelBN/NHsdMcwifemale110.6471mmol/lair oxygen content (12 %) (for 14 days)39196air oxygen content (12 %) (for 14 days)
15hematocritBN/NHsdMcwimale55.28%air oxygen content (12 %) (for 14 days)39069air oxygen content (12 %) (for 14 days)
13hematocritBN/NHsdMcwifemale54.1846%air oxygen content (12 %) (for 14 days)39070air oxygen content (12 %) (for 14 days)
18blood neutrophil countBN/NHsdMcwimale0.8956x 1000 cells/ulnaive control condition (for 14 days)38967naive control condition (for 14 days)
11blood neutrophil countBN/NHsdMcwifemale0.6555x 1000 cells/ulnaive control condition (for 14 days)38968naive control condition (for 14 days)
15mean corpuscular volumeBN/NHsdMcwimale59.0733flair oxygen content (12 %) (for 14 days)38823air oxygen content (12 %) (for 14 days)
13mean corpuscular volumeBN/NHsdMcwifemale56.8077flair oxygen content (12 %) (for 14 days)38824air oxygen content (12 %) (for 14 days)
18mean corpuscular volumeBN/NHsdMcwimale55.2flnaive control condition (for 14 days)38718naive control condition (for 14 days)
11mean corpuscular volumeBN/NHsdMcwifemale54.5727flnaive control condition (for 14 days)38719naive control condition (for 14 days)
20serum glucose levelBN/NHsdMcwimale159.35mg/dlair oxygen content (12 %) (for 14 days)38608air oxygen content (12 %) (for 14 days)
17serum glucose levelBN/NHsdMcwifemale171.9412mg/dlair oxygen content (12 %) (for 14 days)38609air oxygen content (12 %) (for 14 days)
19serum total cholesterol levelBN/NHsdMcwimale64.9474mg/dlnaive control condition (for 14 days)38504naive control condition (for 14 days)
14serum total cholesterol levelBN/NHsdMcwifemale66.4286mg/dlnaive control condition (for 14 days)38505naive control condition (for 14 days)
20plasma anion gapBN/NHsdMcwimale23.8mmol/lair oxygen content (12 %) (for 14 days)38339air oxygen content (12 %) (for 14 days)
17plasma anion gapBN/NHsdMcwifemale21.4118mmol/lair oxygen content (12 %) (for 14 days)38340air oxygen content (12 %) (for 14 days)
16serum potassium levelBN/NHsdMcwimale4.95mmol/lair oxygen content (12 %) (for 14 days)38144air oxygen content (12 %) (for 14 days)
17serum potassium levelBN/NHsdMcwifemale4.8294mmol/lair oxygen content (12 %) (for 14 days)38145air oxygen content (12 %) (for 14 days)
15blood hemoglobin levelBN/NHsdMcwimale17.8333g/dlair oxygen content (12 %) (for 14 days)38046air oxygen content (12 %) (for 14 days)
13blood hemoglobin levelBN/NHsdMcwifemale17.4308g/dlair oxygen content (12 %) (for 14 days)38047air oxygen content (12 %) (for 14 days)
19serum phosphate levelBN/NHsdMcwimale7.6158mg/dlnaive control condition (for 14 days)37898naive control condition (for 14 days)
14serum phosphate levelBN/NHsdMcwifemale7.7357mg/dlnaive control condition (for 14 days)37899naive control condition (for 14 days)
20serum phosphate levelBN/NHsdMcwimale8.04mg/dlair oxygen content (12 %) (for 14 days)37672air oxygen content (12 %) (for 14 days)
17serum phosphate levelBN/NHsdMcwifemale7.9176mg/dlair oxygen content (12 %) (for 14 days)37673air oxygen content (12 %) (for 14 days)
18serum alanine aminotransferase activity levelBN/NHsdMcwimale57.0556U/lnaive control condition (for 14 days)37778naive control condition (for 14 days)
13serum alanine aminotransferase activity levelBN/NHsdMcwifemale36.4615U/lnaive control condition (for 14 days)37779naive control condition (for 14 days)
19serum alkaline phosphatase activity levelBN/NHsdMcwimale170.2632U/lnaive control condition (for 14 days)37521naive control condition (for 14 days)
14serum alkaline phosphatase activity levelBN/NHsdMcwifemale95.4286U/lnaive control condition (for 14 days)37522naive control condition (for 14 days)
18mean corpuscular hemoglobin concentrationBN/NHsdMcwimale32.4833g/dlnaive control condition (for 14 days)37399naive control condition (for 14 days)
11mean corpuscular hemoglobin concentrationBN/NHsdMcwifemale32.3636g/dlnaive control condition (for 14 days)37400naive control condition (for 14 days)
19serum total protein levelBN/NHsdMcwimale5.8368g/dlnaive control condition (for 14 days)37269naive control condition (for 14 days)
14serum total protein levelBN/NHsdMcwifemale5.0429g/dlnaive control condition (for 14 days)37270naive control condition (for 14 days)
20serum total cholesterol levelBN/NHsdMcwimale62mg/dlair oxygen content (12 %) (for 14 days)37175air oxygen content (12 %) (for 14 days)
17serum total cholesterol levelBN/NHsdMcwifemale58.4118mg/dlair oxygen content (12 %) (for 14 days)37176air oxygen content (12 %) (for 14 days)
20serum total protein levelBN/NHsdMcwimale5.76g/dlair oxygen content (12 %) (for 14 days)37040air oxygen content (12 %) (for 14 days)
17serum total protein levelBN/NHsdMcwifemale5.3765g/dlair oxygen content (12 %) (for 14 days)37041air oxygen content (12 %) (for 14 days)
18blood lymphocyte countBN/NHsdMcwimale5.0094x 1000 cells/ulnaive control condition (for 14 days)36940naive control condition (for 14 days)
11blood lymphocyte countBN/NHsdMcwifemale4.0618x 1000 cells/ulnaive control condition (for 14 days)36941naive control condition (for 14 days)
19serum calcium levelBN/NHsdMcwimale9.2368mg/dlnaive control condition (for 14 days)36830naive control condition (for 14 days)
14serum calcium levelBN/NHsdMcwifemale8.8mg/dlnaive control condition (for 14 days)36831naive control condition (for 14 days)
20serum calcium levelBN/NHsdMcwimale8.965mg/dlair oxygen content (12 %) (for 14 days)36702air oxygen content (12 %) (for 14 days)
17serum calcium levelBN/NHsdMcwifemale8.7588mg/dlair oxygen content (12 %) (for 14 days)36703air oxygen content (12 %) (for 14 days)
19serum sodium levelBN/NHsdMcwimale144.7895mmol/lnaive control condition (for 14 days)36561naive control condition (for 14 days)
14serum sodium levelBN/NHsdMcwifemale145.1429mmol/lnaive control condition (for 14 days)36562naive control condition (for 14 days)
20serum alkaline phosphatase activity levelBN/NHsdMcwimale178.3U/lair oxygen content (12 %) (for 14 days)36457air oxygen content (12 %) (for 14 days)
17serum alkaline phosphatase activity levelBN/NHsdMcwifemale125.9412U/lair oxygen content (12 %) (for 14 days)36458air oxygen content (12 %) (for 14 days)
19serum potassium levelBN/NHsdMcwimale4.4368mmol/lnaive control condition (for 14 days)43398naive control condition (for 14 days)
14serum potassium levelBN/NHsdMcwifemale4.2286mmol/lnaive control condition (for 14 days)43399naive control condition (for 14 days)
15blood neutrophil countBN/NHsdMcwimale1.01x 1000 cells/ulair oxygen content (12 %) (for 14 days)43302air oxygen content (12 %) (for 14 days)
13blood neutrophil countBN/NHsdMcwifemale0.9492x 1000 cells/ulair oxygen content (12 %) (for 14 days)43303air oxygen content (12 %) (for 14 days)
18plasma anion gapBN/NHsdMcwimale22.3333mmol/lnaive control condition (for 14 days)43202naive control condition (for 14 days)
14plasma anion gapBN/NHsdMcwifemale21.3571mmol/lnaive control condition (for 14 days)43203naive control condition (for 14 days)
18serum bicarbonate levelBN/NHsdMcwimale21.2778mmol/lnaive control condition (for 14 days)43061naive control condition (for 14 days)
14serum bicarbonate levelBN/NHsdMcwifemale20.7857mmol/lnaive control condition (for 14 days)43062naive control condition (for 14 days)
19total serum bilirubin levelBN/NHsdMcwimale0.1mg/dlnaive control condition (for 14 days)42954naive control condition (for 14 days)
14total serum bilirubin levelBN/NHsdMcwifemale0.1mg/dlnaive control condition (for 14 days)42955naive control condition (for 14 days)
20serum aspartate aminotransferase activity levelBN/NHsdMcwimale95.1U/lair oxygen content (12 %) (for 14 days)42848air oxygen content (12 %) (for 14 days)
17serum aspartate aminotransferase activity levelBN/NHsdMcwifemale101.2941U/lair oxygen content (12 %) (for 14 days)42849air oxygen content (12 %) (for 14 days)
19plasma creatinine levelBN/NHsdMcwimale0.2316mg/dlnaive control condition (for 14 days)42717naive control condition (for 14 days)
14plasma creatinine levelBN/NHsdMcwifemale0.2143mg/dlnaive control condition (for 14 days)42718naive control condition (for 14 days)
15mean corpuscular hemoglobin levelBN/NHsdMcwimale19.0667pgair oxygen content (12 %) (for 14 days)42623air oxygen content (12 %) (for 14 days)
13mean corpuscular hemoglobin levelBN/NHsdMcwifemale18.2615pgair oxygen content (12 %) (for 14 days)42624air oxygen content (12 %) (for 14 days)
18serum aspartate aminotransferase activity levelBN/NHsdMcwimale100.6667U/lnaive control condition (for 14 days)42488naive control condition (for 14 days)
13serum aspartate aminotransferase activity levelBN/NHsdMcwifemale88.7692U/lnaive control condition (for 14 days)42489naive control condition (for 14 days)
20serum albumin levelBN/NHsdMcwimale3.65g/dlair oxygen content (12 %) (for 14 days)42311air oxygen content (12 %) (for 14 days)
17serum albumin levelBN/NHsdMcwifemale3.6235g/dlair oxygen content (12 %) (for 14 days)42312air oxygen content (12 %) (for 14 days)
20serum bicarbonate levelBN/NHsdMcwimale16mmol/lair oxygen content (12 %) (for 14 days)42140air oxygen content (12 %) (for 14 days)
17serum bicarbonate levelBN/NHsdMcwifemale16.5294mmol/lair oxygen content (12 %) (for 14 days)42141air oxygen content (12 %) (for 14 days)
18red blood cell countBN/NHsdMcwimale8.2906x 10E6 cells/ulnaive control condition (for 14 days)42040naive control condition (for 14 days)
11red blood cell countBN/NHsdMcwifemale8.0682x 10E6 cells/ulnaive control condition (for 14 days)42041naive control condition (for 14 days)
20total serum bilirubin levelBN/NHsdMcwimale0.1mg/dlair oxygen content (12 %) (for 14 days)41946air oxygen content (12 %) (for 14 days)
17total serum bilirubin levelBN/NHsdMcwifemale0.1mg/dlair oxygen content (12 %) (for 14 days)41947air oxygen content (12 %) (for 14 days)
19serum urea nitrogen levelBN/NHsdMcwimale17.5789mg/dlnaive control condition (for 14 days)41823naive control condition (for 14 days)
14serum urea nitrogen levelBN/NHsdMcwifemale18.5714mg/dlnaive control condition (for 14 days)41824naive control condition (for 14 days)
15blood eosinophil countBN/NHsdMcwimale0.038x 1000 cells/ulair oxygen content (12 %) (for 14 days)41725air oxygen content (12 %) (for 14 days)
13blood eosinophil countBN/NHsdMcwifemale0.1792x 1000 cells/ulair oxygen content (12 %) (for 14 days)41726air oxygen content (12 %) (for 14 days)
15blood lymphocyte countBN/NHsdMcwimale5.7x 1000 cells/ulair oxygen content (12 %) (for 14 days)41581air oxygen content (12 %) (for 14 days)
13blood lymphocyte countBN/NHsdMcwifemale6.0338x 1000 cells/ulair oxygen content (12 %) (for 14 days)41582air oxygen content (12 %) (for 14 days)
18blood eosinophil countBN/NHsdMcwimale0.0478x 1000 cells/ulnaive control condition (for 14 days)41475naive control condition (for 14 days)
11blood eosinophil countBN/NHsdMcwifemale0.0927x 1000 cells/ulnaive control condition (for 14 days)41476naive control condition (for 14 days)
18hematocritBN/NHsdMcwimale45.7889%naive control condition (for 14 days)41373naive control condition (for 14 days)
11hematocritBN/NHsdMcwifemale44.0364%naive control condition (for 14 days)41374naive control condition (for 14 days)
19serum glucose levelBN/NHsdMcwimale166.7368mg/dlnaive control condition (for 14 days)41265naive control condition (for 14 days)
14serum glucose levelBN/NHsdMcwifemale164.3571mg/dlnaive control condition (for 14 days)41266naive control condition (for 14 days)
19serum globulin levelBN/NHsdMcwimale2.2053g/dlnaive control condition (for 14 days)41098naive control condition (for 14 days)
14serum globulin levelBN/NHsdMcwifemale1.8071g/dlnaive control condition (for 14 days)41099naive control condition (for 14 days)
15total white blood cell countBN/NHsdMcwimale6.44x 1000 cells/ulair oxygen content (12 %) (for 14 days)41004air oxygen content (12 %) (for 14 days)
13total white blood cell countBN/NHsdMcwifemale7.2538x 1000 cells/ulair oxygen content (12 %) (for 14 days)41005air oxygen content (12 %) (for 14 days)
20serum urea nitrogen levelBN/NHsdMcwimale19.6mg/dlair oxygen content (12 %) (for 14 days)40906air oxygen content (12 %) (for 14 days)
17serum urea nitrogen levelBN/NHsdMcwifemale24mg/dlair oxygen content (12 %) (for 14 days)40907air oxygen content (12 %) (for 14 days)
20serum alanine aminotransferase activity levelBN/NHsdMcwimale47.55U/lair oxygen content (12 %) (for 14 days)40792air oxygen content (12 %) (for 14 days)
17serum alanine aminotransferase activity levelBN/NHsdMcwifemale47.9412U/lair oxygen content (12 %) (for 14 days)40793air oxygen content (12 %) (for 14 days)
20serum globulin levelBN/NHsdMcwimale2.11g/dlair oxygen content (12 %) (for 14 days)40628air oxygen content (12 %) (for 14 days)
17serum globulin levelBN/NHsdMcwifemale1.7529g/dlair oxygen content (12 %) (for 14 days)40629air oxygen content (12 %) (for 14 days)
19serum albumin levelBN/NHsdMcwimale3.6316g/dlnaive control condition (for 14 days)40478naive control condition (for 14 days)
14serum albumin levelBN/NHsdMcwifemale3.2357g/dlnaive control condition (for 14 days)40479naive control condition (for 14 days)
18blood monocyte countBN/NHsdMcwimale0.2944x 1000 cells/ulnaive control condition (for 14 days)40365naive control condition (for 14 days)
11blood monocyte countBN/NHsdMcwifemale0.2064x 1000 cells/ulnaive control condition (for 14 days)40366naive control condition (for 14 days)
18mean corpuscular hemoglobin levelBN/NHsdMcwimale17.9222pgnaive control condition (for 14 days)40269naive control condition (for 14 days)
11mean corpuscular hemoglobin levelBN/NHsdMcwifemale17.6545pgnaive control condition (for 14 days)40270naive control condition (for 14 days)
18blood hemoglobin levelBN/NHsdMcwimale14.8667g/dlnaive control condition (for 14 days)40173naive control condition (for 14 days)
11blood hemoglobin levelBN/NHsdMcwifemale14.2364g/dlnaive control condition (for 14 days)40174naive control condition (for 14 days)
19serum chloride levelBN/NHsdMcwimale105.5789mmol/lnaive control condition (for 14 days)40077naive control condition (for 14 days)
14serum chloride levelBN/NHsdMcwifemale107.2143mmol/lnaive control condition (for 14 days)40078naive control condition (for 14 days)
8heart rateBN/NHsdMcwimale408.0425beats/mincontrolled sodium content diet (4 %) (between 17 and 36 days)51291controlled sodium content diet (4 %) (between 17 and 36 days)
8heart rateBN/NHsdMcwifemale409.3675beats/mincontrolled sodium content diet (4 %) (between 17 and 36 days)51292controlled sodium content diet (4 %) (between 17 and 36 days)
3urine sodium excretion rateBN/NHsdMcwimale0.9467mEq/dcontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days)51275controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
9urine sodium excretion rateBN/NHsdMcwifemale1.2322mEq/dcontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days)51276controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
1heart rateBN/NHsdMcwimale432.84beats/mincontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days)51254controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
3heart rateBN/NHsdMcwifemale388.8133beats/mincontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days)51255controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
8absolute change in heart rateBN/NHsdMcwimale-1.395beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours)51240controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours)
4absolute change in heart rateBN/NHsdMcwifemale-11.35beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours)51241controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours)
7absolute change in heart rateBN/NHsdMcwimale-61.8871beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours)51229controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours)
8absolute change in heart rateBN/NHsdMcwifemale-79.11beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours)51230controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours)
4absolute change in heart rateBN/NHsdMcwimale-24.8beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours)51209controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours)
9absolute change in heart rateBN/NHsdMcwifemale-16.6544beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours)51210controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours)
7absolute change in mean arterial blood pressureBN/NHsdMcwimale17.5171mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours)51195controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours)
8absolute change in mean arterial blood pressureBN/NHsdMcwifemale18.3325mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours)51196controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours)
2plasma creatinine levelBN/NHsdMcwifemale0.255mg/dlcontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days)51179controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
7absolute change in heart rateBN/NHsdMcwimale-3.93beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours)51165controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (for 0.2 hours)angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours)
8absolute change in heart rateBN/NHsdMcwifemale-35.16beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours)51166controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (for 0.2 hours)angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours)
4mean arterial blood pressureBN/NHsdMcwimale114.16mmHgcontrolled sodium content diet (4 %) (between 17 and 36 days)51151controlled sodium content diet (4 %) (between 17 and 36 days)
9mean arterial blood pressureBN/NHsdMcwifemale107.0433mmHgcontrolled sodium content diet (4 %) (between 17 and 36 days)51152controlled sodium content diet (4 %) (between 17 and 36 days)
8absolute change in mean arterial blood pressureBN/NHsdMcwimale0.1mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours)51136controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (for 0.2 hours)norepinephrine (0.5 ng/kg/min) (for 0.2 hours)norepinephrine (1 ng/kg/min) (for 0.2 hours)
4absolute change in mean arterial blood pressureBN/NHsdMcwifemale8.88mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours)51137controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (for 0.2 hours)norepinephrine (0.5 ng/kg/min) (for 0.2 hours)norepinephrine (1 ng/kg/min) (for 0.2 hours)
4heart rateBN/NHsdMcwimale384.75beats/mincontrolled sodium content diet (4 %) (between 17 and 36 days)51123controlled sodium content diet (4 %) (between 17 and 36 days)
8heart rateBN/NHsdMcwifemale431.0563beats/mincontrolled sodium content diet (4 %) (between 17 and 36 days)51124controlled sodium content diet (4 %) (between 17 and 36 days)
4absolute change in mean arterial blood pressureBN/NHsdMcwimale8.9575mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours)51110controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours)
8absolute change in mean arterial blood pressureBN/NHsdMcwifemale0.5962mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours)51111controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours)
1absolute change in heart rateBN/NHsdMcwimale68.68beats/mincontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days)51097controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
3absolute change in heart rateBN/NHsdMcwifemale-11.6133beats/mincontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days)51098controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
3creatinine clearanceBN/NHsdMcwimale1.39ml/mincontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days)51063controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
3creatinine clearanceBN/NHsdMcwifemale0.7967ml/mincontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days)51064controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
4absolute change in mean arterial blood pressureBN/NHsdMcwimale7.3225mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours)51030controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (for 0.2 hours)angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours)
9absolute change in mean arterial blood pressureBN/NHsdMcwifemale13.0744mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours)51031controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (for 0.2 hours)angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours)
1plasma renin activity levelBN/NHsdMcwimale8.99ng/ml/hcontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days)51014controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
3plasma renin activity levelBN/NHsdMcwifemale7.6367ng/ml/hcontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days)51015controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
5absolute change in heart rateBN/NHsdMcwimale-28.938beats/mincontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days)50988controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
4absolute change in heart rateBN/NHsdMcwifemale-5.245beats/mincontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days)50989controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
7absolute change in mean arterial blood pressureBN/NHsdMcwimale31.3329mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours)50972controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours)
8absolute change in mean arterial blood pressureBN/NHsdMcwifemale33.3488mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours)50973controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours)
7mean arterial blood pressureBN/NHsdMcwimale109.1486mmHgcontrolled sodium content diet (4 %) (between 17 and 36 days)50950controlled sodium content diet (4 %) (between 17 and 36 days)
8mean arterial blood pressureBN/NHsdMcwifemale110.4738mmHgcontrolled sodium content diet (4 %) (between 17 and 36 days)50951controlled sodium content diet (4 %) (between 17 and 36 days)
4absolute change in mean arterial blood pressureBN/NHsdMcwimale3.95mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours)50936controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (for 0.2 hours)norepinephrine (0.5 ng/kg/min) (for 0.2 hours)norepinephrine (1 ng/kg/min) (for 0.2 hours)
8absolute change in mean arterial blood pressureBN/NHsdMcwifemale2.2275mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours)50937controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (for 0.2 hours)norepinephrine (0.5 ng/kg/min) (for 0.2 hours)norepinephrine (1 ng/kg/min) (for 0.2 hours)
8absolute change in mean arterial blood pressureBN/NHsdMcwimale4.6775mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours)50920controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours)
4absolute change in mean arterial blood pressureBN/NHsdMcwifemale5.4025mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours)50921controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours)
5heart rateBN/NHsdMcwimale375.456beats/mincontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days)50889controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
4heart rateBN/NHsdMcwifemale392.7175beats/mincontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days)50890controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
5absolute change in mean arterial blood pressureBN/NHsdMcwimale-7.15mmHgcontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days)50812controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
4absolute change in mean arterial blood pressureBN/NHsdMcwifemale-9.46mmHgcontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days)50813controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
8absolute change in mean arterial blood pressureBN/NHsdMcwimale3.4588mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours)50781controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours)
4absolute change in mean arterial blood pressureBN/NHsdMcwifemale5.645mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours)50782controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours)
4absolute change in mean arterial blood pressureBN/NHsdMcwimale34.9425mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours)50759controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours)
9absolute change in mean arterial blood pressureBN/NHsdMcwifemale33.6211mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours)50760controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours)
8mean arterial blood pressureBN/NHsdMcwimale101.3012mmHgcontrolled sodium content diet (4 %) (between 17 and 36 days)50745controlled sodium content diet (4 %) (between 17 and 36 days)
8mean arterial blood pressureBN/NHsdMcwifemale102.5262mmHgcontrolled sodium content diet (4 %) (between 17 and 36 days)50746controlled sodium content diet (4 %) (between 17 and 36 days)
4absolute change in heart rateBN/NHsdMcwimale-12.7beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours)50727controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (for 0.2 hours)norepinephrine (0.5 ng/kg/min) (for 0.2 hours)norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours)
8absolute change in heart rateBN/NHsdMcwifemale-25.2062beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours)50728controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (for 0.2 hours)norepinephrine (0.5 ng/kg/min) (for 0.2 hours)norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours)
7absolute change in mean arterial blood pressureBN/NHsdMcwimale0.72mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours)50706controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (for 0.2 hours)angiotensin (25 ng/kg/min) (for 0.2 hours)angiotensin (50 ng/kg/min) (for 0.2 hours)
8absolute change in mean arterial blood pressureBN/NHsdMcwifemale3.5525mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours)50707controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (for 0.2 hours)angiotensin (25 ng/kg/min) (for 0.2 hours)angiotensin (50 ng/kg/min) (for 0.2 hours)
8absolute change in heart rateBN/NHsdMcwimale2.8262beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours)50687controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (for 0.2 hours)norepinephrine (0.5 ng/kg/min) (for 0.2 hours)norepinephrine (1 ng/kg/min) (for 0.2 hours)
4absolute change in heart rateBN/NHsdMcwifemale34.55beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours)50688controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (for 0.2 hours)norepinephrine (0.5 ng/kg/min) (for 0.2 hours)norepinephrine (1 ng/kg/min) (for 0.2 hours)
7absolute change in mean arterial blood pressureBN/NHsdMcwimale39.2643mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours)50664controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (for 0.2 hours)angiotensin (25 ng/kg/min) (for 0.2 hours)angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours)
8absolute change in mean arterial blood pressureBN/NHsdMcwifemale39.8238mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours)50665controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (for 0.2 hours)angiotensin (25 ng/kg/min) (for 0.2 hours)angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours)
1mean arterial blood pressureBN/NHsdMcwimale106.57mmHgcontrolled sodium content diet (4 %) (between 17 and 36 days)50650controlled sodium content diet (4 %) (between 17 and 36 days)
8mean arterial blood pressureBN/NHsdMcwifemale101.04mmHgcontrolled sodium content diet (4 %) (between 17 and 36 days)50651controlled sodium content diet (4 %) (between 17 and 36 days)
1absolute change in mean arterial blood pressureBN/NHsdMcwimale5.59mmHgcontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days)50636controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
3absolute change in mean arterial blood pressureBN/NHsdMcwifemale-2.0333mmHgcontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days)50637controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
4absolute change in heart rateBN/NHsdMcwimale-26.25beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours)50623controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (for 0.2 hours)angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours)
9absolute change in heart rateBN/NHsdMcwifemale0.2789beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours)50624controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (for 0.2 hours)angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours)
4absolute change in mean arterial blood pressureBN/NHsdMcwimale2.6325mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours)50609controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours)
8absolute change in mean arterial blood pressureBN/NHsdMcwifemale0.695mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours)50610controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours)
8absolute change in heart rateBN/NHsdMcwimale-47.9625beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours)50589controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (for 0.2 hours)norepinephrine (0.5 ng/kg/min) (for 0.2 hours)norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours)
4absolute change in heart rateBN/NHsdMcwifemale-24.45beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours)50590controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (for 0.2 hours)norepinephrine (0.5 ng/kg/min) (for 0.2 hours)norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours)
4heart rateBN/NHsdMcwimale399.8beats/mincontrolled sodium content diet (4 %) (between 17 and 36 days)50533controlled sodium content diet (4 %) (between 17 and 36 days)
9heart rateBN/NHsdMcwifemale443.0767beats/mincontrolled sodium content diet (4 %) (between 17 and 36 days)50534controlled sodium content diet (4 %) (between 17 and 36 days)
4absolute change in heart rateBN/NHsdMcwimale20.6beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours)50513controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (for 0.2 hours)norepinephrine (0.5 ng/kg/min) (for 0.2 hours)norepinephrine (1 ng/kg/min) (for 0.2 hours)
8absolute change in heart rateBN/NHsdMcwifemale32.4475beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours)50514controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (for 0.2 hours)norepinephrine (0.5 ng/kg/min) (for 0.2 hours)norepinephrine (1 ng/kg/min) (for 0.2 hours)
1absolute change in plasma renin activity levelBN/NHsdMcwimale5.62ng angI/ml/hcontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days)50496controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
3absolute change in plasma renin activity levelBN/NHsdMcwifemale6.0567ng angI/ml/hcontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days)50497controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
7heart rateBN/NHsdMcwimale392.8343beats/mincontrolled sodium content diet (4 %) (between 17 and 36 days)50482controlled sodium content diet (4 %) (between 17 and 36 days)
8heart rateBN/NHsdMcwifemale402.335beats/mincontrolled sodium content diet (4 %) (between 17 and 36 days)50483controlled sodium content diet (4 %) (between 17 and 36 days)
4absolute change in heart rateBN/NHsdMcwimale-3.15beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours)50428controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (for 0.2 hours)norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours)
8absolute change in heart rateBN/NHsdMcwifemale-8.4812beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours)50429controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (for 0.2 hours)norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours)
7absolute change in mean arterial blood pressureBN/NHsdMcwimale11.7329mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours)50377controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (for 0.2 hours)angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours)
8absolute change in mean arterial blood pressureBN/NHsdMcwifemale3.6063mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours)50378controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (for 0.2 hours)angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours)
8absolute change in heart rateBN/NHsdMcwimale-34.8375beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours)50362controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (for 0.2 hours)norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours)
4absolute change in heart rateBN/NHsdMcwifemale-45.2725beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours)50363controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (for 0.2 hours)norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours)
8heart rateBN/NHsdMcwimale389.05beats/mincontrolled sodium content diet (4 %) (between 17 and 36 days)50330controlled sodium content diet (4 %) (between 17 and 36 days)
4heart rateBN/NHsdMcwifemale435.45beats/mincontrolled sodium content diet (4 %) (between 17 and 36 days)50331controlled sodium content diet (4 %) (between 17 and 36 days)
8mean arterial blood pressureBN/NHsdMcwimale104.9325mmHgcontrolled sodium content diet (4 %) (between 17 and 36 days)52091controlled sodium content diet (4 %) (between 17 and 36 days)
4mean arterial blood pressureBN/NHsdMcwifemale104.2525mmHgcontrolled sodium content diet (4 %) (between 17 and 36 days)52092controlled sodium content diet (4 %) (between 17 and 36 days)
4absolute change in heart rateBN/NHsdMcwimale-6.75beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours)52058controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours)
8absolute change in heart rateBN/NHsdMcwifemale-6.2475beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours)52059controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours)
2plasma creatinine levelBN/NHsdMcwifemale0.27mg/dlcontrolled sodium content diet (4 %) (between 17 and 36 days)52043controlled sodium content diet (4 %) (between 17 and 36 days)
3urine sodium excretion rateBN/NHsdMcwimale12.3333mEq/dcontrolled sodium content diet (4 %) (between 17 and 36 days)52021controlled sodium content diet (4 %) (between 17 and 36 days)
9urine sodium excretion rateBN/NHsdMcwifemale10.8122mEq/dcontrolled sodium content diet (4 %) (between 17 and 36 days)52022controlled sodium content diet (4 %) (between 17 and 36 days)
5mean arterial blood pressureBN/NHsdMcwimale91.89mmHgcontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days)52008controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
4mean arterial blood pressureBN/NHsdMcwifemale91.7875mmHgcontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days)52009controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
8absolute change in mean arterial blood pressureBN/NHsdMcwimale7.06mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours)51970controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (for 0.2 hours)norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours)
4absolute change in mean arterial blood pressureBN/NHsdMcwifemale8.9425mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours)51971controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (for 0.2 hours)norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours)
3creatinine clearanceBN/NHsdMcwimale1.49ml/mincontrolled sodium content diet (4 %) (between 17 and 36 days)51955controlled sodium content diet (4 %) (between 17 and 36 days)
6creatinine clearanceBN/NHsdMcwifemale1.2767ml/mincontrolled sodium content diet (4 %) (between 17 and 36 days)51956controlled sodium content diet (4 %) (between 17 and 36 days)
8absolute change in heart rateBN/NHsdMcwimale7.1663beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours)51927controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours)
4absolute change in heart rateBN/NHsdMcwifemale-26.7beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours)51928controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours)
10urine sodium excretion rateBN/NHsdMcwimale11.633mEq/dcontrolled sodium content diet (4 %) (between 17 and 36 days)51893controlled sodium content diet (4 %) (between 17 and 36 days)
10urine sodium excretion rateBN/NHsdMcwifemale10.899mEq/dcontrolled sodium content diet (4 %) (between 17 and 36 days)51894controlled sodium content diet (4 %) (between 17 and 36 days)
4absolute change in mean arterial blood pressureBN/NHsdMcwimale19.38mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours)51873controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (for 0.2 hours)norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours)
8absolute change in mean arterial blood pressureBN/NHsdMcwifemale13.045mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours)51874controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (for 0.2 hours)norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours)
4absolute change in heart rateBN/NHsdMcwimale-7.05beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours)51858controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (for 0.2 hours)angiotensin (25 ng/kg/min) (for 0.2 hours)angiotensin (50 ng/kg/min) (for 0.2 hours)
9absolute change in heart rateBN/NHsdMcwifemale11.1233beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours)51859controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (for 0.2 hours)angiotensin (25 ng/kg/min) (for 0.2 hours)angiotensin (50 ng/kg/min) (for 0.2 hours)
3plasma renin activity levelBN/NHsdMcwimale2.0567ng/ml/hcontrolled sodium content diet (4 %) (between 17 and 36 days)51844controlled sodium content diet (4 %) (between 17 and 36 days)
5plasma renin activity levelBN/NHsdMcwifemale1.48ng/ml/hcontrolled sodium content diet (4 %) (between 17 and 36 days)51845controlled sodium content diet (4 %) (between 17 and 36 days)
1mean arterial blood pressureBN/NHsdMcwimale112.16mmHgcontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days)51830controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
3mean arterial blood pressureBN/NHsdMcwifemale97.79mmHgcontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days)51831controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
2creatinine clearanceBN/NHsdMcwifemale1.645ml/mincontrolled sodium content diet (4 %) (between 17 and 36 days)51804controlled sodium content diet (4 %) (between 17 and 36 days)
4absolute change in mean arterial blood pressureBN/NHsdMcwimale30.3275mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours)51778controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (for 0.2 hours)norepinephrine (0.5 ng/kg/min) (for 0.2 hours)norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours)
8absolute change in mean arterial blood pressureBN/NHsdMcwifemale16.0825mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours)51779controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (for 0.2 hours)norepinephrine (0.5 ng/kg/min) (for 0.2 hours)norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours)
10urine total protein excretion rateBN/NHsdMcwimale10.607mg/dcontrolled sodium content diet (4 %) (between 17 and 36 days)51761controlled sodium content diet (4 %) (between 17 and 36 days)
10urine total protein excretion rateBN/NHsdMcwifemale19.714mg/dcontrolled sodium content diet (4 %) (between 17 and 36 days)51762controlled sodium content diet (4 %) (between 17 and 36 days)
7absolute change in heart rateBN/NHsdMcwimale-13.0914beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours)51729controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (for 0.2 hours)angiotensin (25 ng/kg/min) (for 0.2 hours)angiotensin (50 ng/kg/min) (for 0.2 hours)
8absolute change in heart rateBN/NHsdMcwifemale-38.4775beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours)51730controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (for 0.2 hours)angiotensin (25 ng/kg/min) (for 0.2 hours)angiotensin (50 ng/kg/min) (for 0.2 hours)
7absolute change in heart rateBN/NHsdMcwimale-96.5729beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours)51715controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (for 0.2 hours)angiotensin (25 ng/kg/min) (for 0.2 hours)angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours)
8absolute change in heart rateBN/NHsdMcwifemale-112.51beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours)51716controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (for 0.2 hours)angiotensin (25 ng/kg/min) (for 0.2 hours)angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours)
4absolute change in heart rateBN/NHsdMcwimale-74.95beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours)51701controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (for 0.2 hours)angiotensin (25 ng/kg/min) (for 0.2 hours)angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours)
9absolute change in heart rateBN/NHsdMcwifemale-63.9189beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours)51702controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (for 0.2 hours)angiotensin (25 ng/kg/min) (for 0.2 hours)angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours)
8absolute change in mean arterial blood pressureBN/NHsdMcwimale23.0438mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours)51666controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (for 0.2 hours)norepinephrine (0.5 ng/kg/min) (for 0.2 hours)norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours)
4absolute change in mean arterial blood pressureBN/NHsdMcwifemale31.1875mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours)51667controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (for 0.2 hours)norepinephrine (0.2 ng/kg/min) (for 0.2 hours)norepinephrine (0.5 ng/kg/min) (for 0.2 hours)norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours)
3plasma creatinine levelBN/NHsdMcwimale0.2817mg/dlcontrolled sodium content diet (4 %) (between 17 and 36 days)51655controlled sodium content diet (4 %) (between 17 and 36 days)
6plasma creatinine levelBN/NHsdMcwifemale0.2808mg/dlcontrolled sodium content diet (4 %) (between 17 and 36 days)51656controlled sodium content diet (4 %) (between 17 and 36 days)
4mean arterial blood pressureBN/NHsdMcwimale107.8825mmHgcontrolled sodium content diet (4 %) (between 17 and 36 days)51637controlled sodium content diet (4 %) (between 17 and 36 days)
8mean arterial blood pressureBN/NHsdMcwifemale103.815mmHgcontrolled sodium content diet (4 %) (between 17 and 36 days)51638controlled sodium content diet (4 %) (between 17 and 36 days)
4absolute change in mean arterial blood pressureBN/NHsdMcwimale-3.515mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours)51601controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (for 0.2 hours)angiotensin (25 ng/kg/min) (for 0.2 hours)angiotensin (50 ng/kg/min) (for 0.2 hours)
9absolute change in mean arterial blood pressureBN/NHsdMcwifemale7.0256mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours)51602controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (for 0.2 hours)angiotensin (25 ng/kg/min) (for 0.2 hours)angiotensin (50 ng/kg/min) (for 0.2 hours)
1heart rateBN/NHsdMcwimale364.17beats/mincontrolled sodium content diet (4 %) (between 17 and 36 days)51587controlled sodium content diet (4 %) (between 17 and 36 days)
8heart rateBN/NHsdMcwifemale437.795beats/mincontrolled sodium content diet (4 %) (between 17 and 36 days)51588controlled sodium content diet (4 %) (between 17 and 36 days)
4urine albumin excretion rateBN/NHsdMcwimale1.2225mg/dcontrolled sodium content diet (4 %) (between 17 and 36 days)51571controlled sodium content diet (4 %) (between 17 and 36 days)
9urine albumin excretion rateBN/NHsdMcwifemale0.7756mg/dcontrolled sodium content diet (4 %) (between 17 and 36 days)51572controlled sodium content diet (4 %) (between 17 and 36 days)
2creatinine clearanceBN/NHsdMcwifemale1.55ml/mincontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days)51548controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
10urine sodium excretion rateBN/NHsdMcwimale1.17mEq/dcontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days)51527controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
9urine sodium excretion rateBN/NHsdMcwifemale1.0467mEq/dcontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days)51528controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
4absolute change in heart rateBN/NHsdMcwimale-38.7beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours)51513controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours)
9absolute change in heart rateBN/NHsdMcwifemale-28.8133beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours)51514controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours)
10urine albumin excretion rateBN/NHsdMcwimale0.444mg/dcontrolled sodium content diet (4 %) (between 17 and 36 days)51477controlled sodium content diet (4 %) (between 17 and 36 days)
10urine albumin excretion rateBN/NHsdMcwifemale0.313mg/dcontrolled sodium content diet (4 %) (between 17 and 36 days)51478controlled sodium content diet (4 %) (between 17 and 36 days)
4urine total protein excretion rateBN/NHsdMcwimale16.76mg/dcontrolled sodium content diet (4 %) (between 17 and 36 days)51445controlled sodium content diet (4 %) (between 17 and 36 days)
9urine total protein excretion rateBN/NHsdMcwifemale10.7511mg/dcontrolled sodium content diet (4 %) (between 17 and 36 days)51446controlled sodium content diet (4 %) (between 17 and 36 days)
4absolute change in mean arterial blood pressureBN/NHsdMcwimale39.465mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours)51431controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (for 0.2 hours)angiotensin (25 ng/kg/min) (for 0.2 hours)angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours)
9absolute change in mean arterial blood pressureBN/NHsdMcwifemale43.3789mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours)51432controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (for 0.2 hours)angiotensin (10 ng/kg/min) (for 0.2 hours)angiotensin (25 ng/kg/min) (for 0.2 hours)angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours)
4absolute change in heart rateBN/NHsdMcwimale0.75beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours)51377controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours)
8absolute change in heart rateBN/NHsdMcwifemale10.88beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours)51378controlled sodium content diet (4 %) (between 24 and 31 days)norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours)
7absolute change in heart rateBN/NHsdMcwimale-19.9586beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours)51360controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours)
8absolute change in heart rateBN/NHsdMcwifemale-55.31beats/mincontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours)51361controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours)
4absolute change in mean arterial blood pressureBN/NHsdMcwimale17.7375mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours)51346controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours)
9absolute change in mean arterial blood pressureBN/NHsdMcwifemale20.6767mmHgcontrolled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours)51347controlled sodium content diet (4 %) (between 24 and 31 days)angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours)
3plasma creatinine levelBN/NHsdMcwimale0.2867mg/dlcontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days)51321controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
3plasma creatinine levelBN/NHsdMcwifemale0.2967mg/dlcontrolled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days)51322controlled sodium content diet (4 %) (between 17 and 36 days)furosemide (10 mg/kg) controlled sodium content diet (0.4 %) (for 2 days)
45heart left ventricle wet weightBN/NHsdMcwimale0.509gcontrolled sodium content diet (4 %) (for 14 days)63794controlled sodium content diet (4 %) (for 14 days)
29heart left ventricle wet weightBN/NHsdMcwifemale0.3511gcontrolled sodium content diet (4 %) (for 14 days)63795controlled sodium content diet (4 %) (for 14 days)
45body length, nose to tailBN/NHsdMcwimale37.8cmcontrolled sodium content diet (4 %) (for 14 days)63722controlled sodium content diet (4 %) (for 14 days)
26body length, nose to tailBN/NHsdMcwifemale34.8808cmcontrolled sodium content diet (4 %) (for 14 days)63723controlled sodium content diet (4 %) (for 14 days)
45body weightBN/NHsdMcwimale236.4gcontrolled sodium content diet (4 %) (for 14 days)63650controlled sodium content diet (4 %) (for 14 days)
29body weightBN/NHsdMcwifemale153.3793gcontrolled sodium content diet (4 %) (for 14 days)63651controlled sodium content diet (4 %) (for 14 days)
45body length, nose to rumpBN/NHsdMcwimale22.2889cmcontrolled sodium content diet (4 %) (for 14 days)63568controlled sodium content diet (4 %) (for 14 days)
26body length, nose to rumpBN/NHsdMcwifemale20.3846cmcontrolled sodium content diet (4 %) (for 14 days)63569controlled sodium content diet (4 %) (for 14 days)
45heart wet weightBN/NHsdMcwimale0.7395gcontrolled sodium content diet (4 %) (for 14 days)63476controlled sodium content diet (4 %) (for 14 days)
29heart wet weightBN/NHsdMcwifemale0.5173gcontrolled sodium content diet (4 %) (for 14 days)63477controlled sodium content diet (4 %) (for 14 days)
45left kidney wet weightBN/NHsdMcwimale0.808gcontrolled sodium content diet (4 %) (for 14 days)63404controlled sodium content diet (4 %) (for 14 days)
29left kidney wet weightBN/NHsdMcwifemale0.5214gcontrolled sodium content diet (4 %) (for 14 days)63405controlled sodium content diet (4 %) (for 14 days)
44heart right ventricle wet weightBN/NHsdMcwimale0.152gcontrolled sodium content diet (4 %) (for 14 days)63332controlled sodium content diet (4 %) (for 14 days)
29heart right ventricle wet weightBN/NHsdMcwifemale0.1066gcontrolled sodium content diet (4 %) (for 14 days)63333controlled sodium content diet (4 %) (for 14 days)
23minute ventilation (VE)BN/NHsdMcwimale32.3129ml/minair oxygen content (12 %) (between 0 and 0.1 hours)18741air oxygen content (12 %) (between 0 and 0.1 hours)
18minute ventilation (VE)BN/NHsdMcwifemale28.9242ml/minair oxygen content (12 %) (between 0 and 0.1 hours)18742air oxygen content (12 %) (between 0 and 0.1 hours)
9tidal volumeBN/NHsdMcwimale0.3144mlnaive control condition18635naive control condition
8tidal volumeBN/NHsdMcwifemale0.2875mlnaive control condition18636naive control condition
23percent change in ventilationBN/NHsdMcwimale115.9303%air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)18622air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
18percent change in ventilationBN/NHsdMcwifemale124.9936%air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)18623air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
23body weightBN/NHsdMcwimale227.9gnaive control condition17896naive control condition
24body weightBN/NHsdMcwifemale149.2gnaive control condition17897naive control condition
9body weightBN/NHsdMcwimale232.8gnaive control condition18502naive control condition
8body weightBN/NHsdMcwifemale150.9gnaive control condition18503naive control condition
23respiration rateBN/NHsdMcwimale90.2364breaths/minnaive control condition18489naive control condition
18respiration rateBN/NHsdMcwifemale88.4891breaths/minnaive control condition18490naive control condition
3absolute change in heart rateBN/NHsdMcwimale92.0933beats/minresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)18366resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
3absolute change in heart rateBN/NHsdMcwifemale62.9333beats/minresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)18367resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
23respiration rateBN/NHsdMcwimale110.3741breaths/minair oxygen content (12 %) (between 0 and 0.1 hours)18344air oxygen content (12 %) (between 0 and 0.1 hours)
18respiration rateBN/NHsdMcwifemale116.598breaths/minair oxygen content (12 %) (between 0 and 0.1 hours)18345air oxygen content (12 %) (between 0 and 0.1 hours)
9body temperatureBN/NHsdMcwimale36.5444degrees Cair oxygen content (12 %) (for 0.1 hours)18236air oxygen content (12 %) (for 0.1 hours)
8body temperatureBN/NHsdMcwifemale37.025degrees Cair oxygen content (12 %) (for 0.1 hours)18237air oxygen content (12 %) (for 0.1 hours)
18body temperatureBN/NHsdMcwimale38.0333degrees Cresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours)17658resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (for 0.1 hours)
17body temperatureBN/NHsdMcwifemale37.5647degrees Cresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours)17659resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (for 0.1 hours)
9respiration rateBN/NHsdMcwimale109.86breaths/minair carbon dioxide content (7 %) (between 0.1 and 0.1 hours)17624air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
8respiration rateBN/NHsdMcwifemale103.54breaths/minair carbon dioxide content (7 %) (between 0.1 and 0.1 hours)17625air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
9body temperatureBN/NHsdMcwimale37.3444degrees Cnaive control condition17574naive control condition
8body temperatureBN/NHsdMcwifemale38.225degrees Cnaive control condition17575naive control condition
13heart rateBN/NHsdMcwimale226.6923beats/minair oxygen content (12 %) (for 0.1 hours)17547air oxygen content (12 %) (for 0.1 hours)
10heart rateBN/NHsdMcwifemale273.077beats/minair oxygen content (12 %) (for 0.1 hours)17548air oxygen content (12 %) (for 0.1 hours)
18tidal volumeBN/NHsdMcwimale0.3685mlair carbon dioxide content (7 %) (between 0.1 and 0.1 hours)17449air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
16tidal volumeBN/NHsdMcwifemale0.3234mlair carbon dioxide content (7 %) (between 0.1 and 0.1 hours)17450air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
9tidal volumeBN/NHsdMcwimale0.4356mlair carbon dioxide content (7 %) (between 0 and 0.1 hours)17351air carbon dioxide content (7 %) (between 0 and 0.1 hours)
8tidal volumeBN/NHsdMcwifemale0.3975mlair carbon dioxide content (7 %) (between 0 and 0.1 hours)17352air carbon dioxide content (7 %) (between 0 and 0.1 hours)
2partial pressure of blood oxygenBN/NHsdMcwimale97.575mmHgresting on treadmill (between 0.1 and 0.1 hours)17307resting on treadmill (between 0.1 and 0.1 hours)
5partial pressure of blood oxygenBN/NHsdMcwifemale102.43mmHgresting on treadmill (between 0.1 and 0.1 hours)17308resting on treadmill (between 0.1 and 0.1 hours)
12partial pressure of blood carbon dioxide (Pco2)BN/NHsdMcwimale31.4458mmHgair oxygen content (12 %) (for 0.1 hours)17284air oxygen content (12 %) (for 0.1 hours)
8partial pressure of blood carbon dioxide (Pco2)BN/NHsdMcwifemale31.7688mmHgair oxygen content (12 %) (for 0.1 hours)17285air oxygen content (12 %) (for 0.1 hours)
18respiration rateBN/NHsdMcwimale111.5077breaths/minair carbon dioxide content (7 %) (between 0.1 and 0.1 hours)17190air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
16respiration rateBN/NHsdMcwifemale113.801breaths/minair carbon dioxide content (7 %) (between 0.1 and 0.1 hours)17191air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
23tidal volumeBN/NHsdMcwimale0.298mlair oxygen content (12 %) (between 0 and 0.1 hours)14002air oxygen content (12 %) (between 0 and 0.1 hours)
18tidal volumeBN/NHsdMcwifemale0.2526mlair oxygen content (12 %) (between 0 and 0.1 hours)14003air oxygen content (12 %) (between 0 and 0.1 hours)
3mean arterial blood pressureBN/NHsdMcwimale114.0967mmHgair carbon dioxide content (7 %) (for 0.1 hours)13894air carbon dioxide content (7 %) (for 0.1 hours)
5mean arterial blood pressureBN/NHsdMcwifemale104.252mmHgair carbon dioxide content (7 %) (for 0.1 hours)13895air carbon dioxide content (7 %) (for 0.1 hours)
4partial pressure of blood carbon dioxide (Pco2)BN/NHsdMcwimale33.6875mmHgnaive control condition13844naive control condition
7partial pressure of blood carbon dioxide (Pco2)BN/NHsdMcwifemale34.2286mmHgnaive control condition13845naive control condition
13heart rateBN/NHsdMcwimale464.2915beats/minresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)13813resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
15heart rateBN/NHsdMcwifemale470.7187beats/minresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)13814resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
3mean arterial blood pressureBN/NHsdMcwimale120.13mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)13772resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
5mean arterial blood pressureBN/NHsdMcwifemale104.414mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)13773resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
23percent change in ventilationBN/NHsdMcwimale141.8764%air oxygen content (12 %) (between 0 and 0.1 hours)13759air oxygen content (12 %) (between 0 and 0.1 hours)
18percent change in ventilationBN/NHsdMcwifemale154.4793%air oxygen content (12 %) (between 0 and 0.1 hours)13760air oxygen content (12 %) (between 0 and 0.1 hours)
9tidal volumeBN/NHsdMcwimale0.36mlair oxygen content (12 %) (between 0 and 0.1 hours)13651air oxygen content (12 %) (between 0 and 0.1 hours)
8tidal volumeBN/NHsdMcwifemale0.3mlair oxygen content (12 %) (between 0 and 0.1 hours)13652air oxygen content (12 %) (between 0 and 0.1 hours)
18body temperatureBN/NHsdMcwimale35.5167degrees Cair carbon dioxide content (7 %) (for 0.1 hours)13638air carbon dioxide content (7 %) (for 0.1 hours)
16body temperatureBN/NHsdMcwifemale34.8062degrees Cair carbon dioxide content (7 %) (for 0.1 hours)13639air carbon dioxide content (7 %) (for 0.1 hours)
8mean arterial blood pressureBN/NHsdMcwimale126.5838mmHgair carbon dioxide content (7 %) (for 0.1 hours)13526air carbon dioxide content (7 %) (for 0.1 hours)
10mean arterial blood pressureBN/NHsdMcwifemale119.563mmHgair carbon dioxide content (7 %) (for 0.1 hours)13527air carbon dioxide content (7 %) (for 0.1 hours)
13partial pressure of blood carbon dioxide (Pco2)BN/NHsdMcwimale27.6654mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours)13444resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)
15partial pressure of blood carbon dioxide (Pco2)BN/NHsdMcwifemale25.59mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours)13445resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)
13absolute change in heart rateBN/NHsdMcwimale94.5023beats/minresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours)13410resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)
15absolute change in heart rateBN/NHsdMcwifemale63.8707beats/minresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours)13411resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)
14mean arterial blood pressureBN/NHsdMcwimale119.9943mmHgair oxygen content (12 %) (for 0.1 hours)14374air oxygen content (12 %) (for 0.1 hours)
10mean arterial blood pressureBN/NHsdMcwifemale121.365mmHgair oxygen content (12 %) (for 0.1 hours)14375air oxygen content (12 %) (for 0.1 hours)
18percent change in ventilationBN/NHsdMcwimale177.9728%air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)14277air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
16percent change in ventilationBN/NHsdMcwifemale192.1951%air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)14278air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
9minute ventilation (VE)BN/NHsdMcwimale50.5722ml/minair carbon dioxide content (7 %) (between 0 and 0.1 hours)14168air carbon dioxide content (7 %) (between 0 and 0.1 hours)
8minute ventilation (VE)BN/NHsdMcwifemale47.3187ml/minair carbon dioxide content (7 %) (between 0 and 0.1 hours)14169air carbon dioxide content (7 %) (between 0 and 0.1 hours)
9percent change in ventilationBN/NHsdMcwimale143.0829%air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)14093air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
8percent change in ventilationBN/NHsdMcwifemale154.0876%air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)14094air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
3heart rateBN/NHsdMcwimale475.4933beats/minresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)14070resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
5heart rateBN/NHsdMcwifemale525.71beats/minresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)14071resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
8percent change in ventilationBN/NHsdMcwifemale144.2312%air oxygen content (12 %) (between 0 and 0.1 hours)14039air oxygen content (12 %) (between 0 and 0.1 hours)
9percent change in ventilationBN/NHsdMcwimale138.9796%air oxygen content (12 %) (between 0 and 0.1 hours)14038air oxygen content (12 %) (between 0 and 0.1 hours)
1absolute change in partial pressure of blood oxygenBN/NHsdMcwimale19.7mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)14026resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
5absolute change in partial pressure of blood oxygenBN/NHsdMcwifemale12.9mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)14027resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
14mean arterial blood pressureBN/NHsdMcwimale122.7929mmHgnaive control condition15136naive control condition
14mean arterial blood pressureBN/NHsdMcwifemale117.38mmHgnaive control condition15137naive control condition
13partial pressure of blood oxygenBN/NHsdMcwimale113.4192mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)15060resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
15partial pressure of blood oxygenBN/NHsdMcwifemale108.1533mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)15061resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
18respiration rateBN/NHsdMcwimale92.2917breaths/minnaive control condition15014naive control condition
16respiration rateBN/NHsdMcwifemale96.5602breaths/minnaive control condition15015naive control condition
9tidal volumeBN/NHsdMcwimale0.3111mlair oxygen content (12 %) (between 0.1 and 0.1 hours)14906air oxygen content (12 %) (between 0.1 and 0.1 hours)
8tidal volumeBN/NHsdMcwifemale0.2838mlair oxygen content (12 %) (between 0.1 and 0.1 hours)14907air oxygen content (12 %) (between 0.1 and 0.1 hours)
9tidal volumeBN/NHsdMcwimale0.3156mlnaive control condition14886naive control condition
8tidal volumeBN/NHsdMcwifemale0.2938mlnaive control condition14887naive control condition
23respiration rateBN/NHsdMcwimale96.0324breaths/minair oxygen content (12 %) (between 0.1 and 0.1 hours)14873air oxygen content (12 %) (between 0.1 and 0.1 hours)
18respiration rateBN/NHsdMcwifemale103.2499breaths/minair oxygen content (12 %) (between 0.1 and 0.1 hours)14874air oxygen content (12 %) (between 0.1 and 0.1 hours)
12absolute change in blood pHBN/NHsdMcwimale0.0232resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)14775resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
15absolute change in blood pHBN/NHsdMcwifemale0.0048resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)14776resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
8heart rateBN/NHsdMcwimale202.48beats/minair carbon dioxide content (7 %) (for 0.1 hours)14739air carbon dioxide content (7 %) (for 0.1 hours)
10heart rateBN/NHsdMcwifemale239.74beats/minair carbon dioxide content (7 %) (for 0.1 hours)14740air carbon dioxide content (7 %) (for 0.1 hours)
4mean arterial blood pressureBN/NHsdMcwimale99.09mmHgair oxygen content (12 %) (for 0.1 hours)14668air oxygen content (12 %) (for 0.1 hours)
7mean arterial blood pressureBN/NHsdMcwifemale95.6029mmHgair oxygen content (12 %) (for 0.1 hours)14669air oxygen content (12 %) (for 0.1 hours)
18minute ventilation (VE)BN/NHsdMcwimale42.4199ml/minair carbon dioxide content (7 %) (between 0 and 0.1 hours)14579air carbon dioxide content (7 %) (between 0 and 0.1 hours)
16minute ventilation (VE)BN/NHsdMcwifemale39.9981ml/minair carbon dioxide content (7 %) (between 0 and 0.1 hours)14580air carbon dioxide content (7 %) (between 0 and 0.1 hours)
16partial pressure of blood carbon dioxide (Pco2)BN/NHsdMcwimale34.6063mmHgresting on treadmill (between 0.1 and 0.1 hours)14481resting on treadmill (between 0.1 and 0.1 hours)
17partial pressure of blood carbon dioxide (Pco2)BN/NHsdMcwifemale31.9853mmHgresting on treadmill (between 0.1 and 0.1 hours)14482resting on treadmill (between 0.1 and 0.1 hours)
9respiration rateBN/NHsdMcwimale96.9589breaths/minnaive control condition14447naive control condition
8respiration rateBN/NHsdMcwifemale83.3438breaths/minnaive control condition14448naive control condition
2body temperatureBN/NHsdMcwimale38.45degrees Cresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours)18224resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (for 0.1 hours)
5body temperatureBN/NHsdMcwifemale38.2degrees Cresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours)18225resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (for 0.1 hours)
3heart rateBN/NHsdMcwimale394.7033beats/minresting on treadmill (between 0.1 and 0.1 hours)18201resting on treadmill (between 0.1 and 0.1 hours)
5heart rateBN/NHsdMcwifemale441.08beats/minresting on treadmill (between 0.1 and 0.1 hours)18202resting on treadmill (between 0.1 and 0.1 hours)
9minute ventilation (VE)BN/NHsdMcwimale29.2667ml/minnaive control condition18189naive control condition
8minute ventilation (VE)BN/NHsdMcwifemale24.2112ml/minnaive control condition18190naive control condition
18body temperatureBN/NHsdMcwimale37.6778degrees Cresting on treadmill (between 0.1 and 0.1 hours)18142resting on treadmill (between 0.1 and 0.1 hours)
17body temperatureBN/NHsdMcwifemale37.6176degrees Cresting on treadmill (between 0.1 and 0.1 hours)18143resting on treadmill (between 0.1 and 0.1 hours)
4heart rateBN/NHsdMcwimale349.4025beats/minair oxygen content (12 %) (for 0.1 hours)18108air oxygen content (12 %) (for 0.1 hours)
6heart rateBN/NHsdMcwifemale449.47beats/minair oxygen content (12 %) (for 0.1 hours)18109air oxygen content (12 %) (for 0.1 hours)
9minute ventilation (VE)BN/NHsdMcwimale40.7833ml/minair oxygen content (12 %) (between 0 and 0.1 hours)18074air oxygen content (12 %) (between 0 and 0.1 hours)
8minute ventilation (VE)BN/NHsdMcwifemale34.63ml/minair oxygen content (12 %) (between 0 and 0.1 hours)18075air oxygen content (12 %) (between 0 and 0.1 hours)
23tidal volumeBN/NHsdMcwimale0.2619mlnaive control condition18061naive control condition
18tidal volumeBN/NHsdMcwifemale0.2196mlnaive control condition18062naive control condition
3absolute change in partial pressure of blood oxygenBN/NHsdMcwimale-51.1mmHgair oxygen content (12 %) (for 0.1 hours)17942air oxygen content (12 %) (for 0.1 hours)
7absolute change in partial pressure of blood oxygenBN/NHsdMcwifemale-51.1mmHgair oxygen content (12 %) (for 0.1 hours)17943air oxygen content (12 %) (for 0.1 hours)
9percent change in ventilationBN/NHsdMcwimale113.6289%controlled sodium content diet (0 %) then air oxygen content (12 %) (between 0.1 and 0.1 hours)17920controlled sodium content diet (0 %) air oxygen content (12 %) (between 0.1 and 0.1 hours)
8percent change in ventilationBN/NHsdMcwifemale123.1305%controlled sodium content diet (0 %) then air oxygen content (12 %) (between 0.1 and 0.1 hours)17921controlled sodium content diet (0 %) air oxygen content (12 %) (between 0.1 and 0.1 hours)
9respiration rateBN/NHsdMcwimale94.3167breaths/minnaive control condition17798naive control condition
8respiration rateBN/NHsdMcwifemale86.7725breaths/minnaive control condition17799naive control condition
3mean arterial blood pressureBN/NHsdMcwimale136.0067mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)17777resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
3mean arterial blood pressureBN/NHsdMcwifemale114.1767mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)17778resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
17heart rateBN/NHsdMcwimale365.4524beats/minresting on treadmill (between 0.1 and 0.1 hours)17756resting on treadmill (between 0.1 and 0.1 hours)
17heart rateBN/NHsdMcwifemale408.3994beats/minresting on treadmill (between 0.1 and 0.1 hours)17757resting on treadmill (between 0.1 and 0.1 hours)
3absolute change in partial pressure of blood carbon dioxideBN/NHsdMcwimale-6.2333mmHgair oxygen content (12 %) (for 0.1 hours)17714air oxygen content (12 %) (for 0.1 hours)
7absolute change in partial pressure of blood carbon dioxideBN/NHsdMcwifemale-7.15mmHgair oxygen content (12 %) (for 0.1 hours)17715air oxygen content (12 %) (for 0.1 hours)
2partial pressure of blood oxygenBN/NHsdMcwimale103.275mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)17702resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
5partial pressure of blood oxygenBN/NHsdMcwifemale113.35mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)17703resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
9respiration rateBN/NHsdMcwimale112.8267breaths/minair oxygen content (12 %) (between 0 and 0.1 hours)17690air oxygen content (12 %) (between 0 and 0.1 hours)
8respiration rateBN/NHsdMcwifemale116.0288breaths/minair oxygen content (12 %) (between 0 and 0.1 hours)17691air oxygen content (12 %) (between 0 and 0.1 hours)
9tidal volumeBN/NHsdMcwimale0.3911mlair carbon dioxide content (7 %) (between 0.1 and 0.1 hours)17678air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
8tidal volumeBN/NHsdMcwifemale0.3538mlair carbon dioxide content (7 %) (between 0.1 and 0.1 hours)17679air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
18percent change in ventilationBN/NHsdMcwimale177.8775%air carbon dioxide content (7 %) (between 0 and 0.1 hours)19290air carbon dioxide content (7 %) (between 0 and 0.1 hours)
16percent change in ventilationBN/NHsdMcwifemale201.9572%air carbon dioxide content (7 %) (between 0 and 0.1 hours)19291air carbon dioxide content (7 %) (between 0 and 0.1 hours)
2body temperatureBN/NHsdMcwimale37.9degrees Cresting on treadmill (between 0.1 and 0.1 hours)19192resting on treadmill (between 0.1 and 0.1 hours)
5body temperatureBN/NHsdMcwifemale38.14degrees Cresting on treadmill (between 0.1 and 0.1 hours)19193resting on treadmill (between 0.1 and 0.1 hours)
2absolute change in heart rateBN/NHsdMcwimale96.37beats/minresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)19172resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
5absolute change in heart rateBN/NHsdMcwifemale101.434beats/minresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)19173resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
18body temperatureBN/NHsdMcwimale37.05degrees Cnaive control condition19148naive control condition
16body temperatureBN/NHsdMcwifemale36.9125degrees Cnaive control condition19149naive control condition
1partial pressure of blood carbon dioxide (Pco2)BN/NHsdMcwimale24.3mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)19031resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
5partial pressure of blood carbon dioxide (Pco2)BN/NHsdMcwifemale23.84mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)19032resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
13mean arterial blood pressureBN/NHsdMcwimale120.5477mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)18957resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
15mean arterial blood pressureBN/NHsdMcwifemale111.262mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)18958resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
14partial pressure of blood oxygenBN/NHsdMcwimale98.8179mmHgnaive control condition18911naive control condition
10partial pressure of blood oxygenBN/NHsdMcwifemale95.735mmHgnaive control condition18912naive control condition
5partial pressure of blood carbon dioxide (Pco2)BN/NHsdMcwimale22.22mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)18836resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
5partial pressure of blood carbon dioxide (Pco2)BN/NHsdMcwifemale21.24mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)18837resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
1absolute change in blood pHBN/NHsdMcwimale0.03resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)20567resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
5absolute change in blood pHBN/NHsdMcwifemale-0.024resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)20568resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
3absolute change in blood pHBN/NHsdMcwimale0.05air oxygen content (12 %) (for 0.1 hours)20545air oxygen content (12 %) (for 0.1 hours)
7absolute change in blood pHBN/NHsdMcwifemale0.0486air oxygen content (12 %) (for 0.1 hours)20546air oxygen content (12 %) (for 0.1 hours)
2heart rateBN/NHsdMcwimale471.81beats/minresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)20533resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
5heart rateBN/NHsdMcwifemale542.514beats/minresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)20534resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
12partial pressure of blood oxygenBN/NHsdMcwimale54.3292mmHgair oxygen content (12 %) (for 0.1 hours)20519air oxygen content (12 %) (for 0.1 hours)
8partial pressure of blood oxygenBN/NHsdMcwifemale53.575mmHgair oxygen content (12 %) (for 0.1 hours)20520air oxygen content (12 %) (for 0.1 hours)
5heart rateBN/NHsdMcwimale394.664beats/minnaive control condition20441naive control condition
7heart rateBN/NHsdMcwifemale434.1286beats/minnaive control condition20442naive control condition
3absolute change in heart rateBN/NHsdMcwimale80.79beats/minresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)20429resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
5absolute change in heart rateBN/NHsdMcwifemale84.63beats/minresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)20430resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
2partial pressure of blood carbon dioxide (Pco2)BN/NHsdMcwimale28.4mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)20417resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
5partial pressure of blood carbon dioxide (Pco2)BN/NHsdMcwifemale26.91mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)20418resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
3mean arterial blood pressureBN/NHsdMcwimale105.4mmHgresting on treadmill (between 0.1 and 0.1 hours)20401resting on treadmill (between 0.1 and 0.1 hours)
5mean arterial blood pressureBN/NHsdMcwifemale92.848mmHgresting on treadmill (between 0.1 and 0.1 hours)20402resting on treadmill (between 0.1 and 0.1 hours)
23absolute change in body temperatureBN/NHsdMcwimale-1.6391degrees Cair oxygen content (12 %) (for 0.1 hours)20388air oxygen content (12 %) (for 0.1 hours)
18absolute change in body temperatureBN/NHsdMcwifemale-1.7889degrees Cair oxygen content (12 %) (for 0.1 hours)20389air oxygen content (12 %) (for 0.1 hours)
23minute ventilation (VE)BN/NHsdMcwimale26.2972ml/minair oxygen content (12 %) (between 0.1 and 0.1 hours)20287air oxygen content (12 %) (between 0.1 and 0.1 hours)
18minute ventilation (VE)BN/NHsdMcwifemale23.3089ml/minair oxygen content (12 %) (between 0.1 and 0.1 hours)20288air oxygen content (12 %) (between 0.1 and 0.1 hours)
12blood pHBN/NHsdMcwimale7.4692air oxygen content (12 %) (for 0.1 hours)17091air oxygen content (12 %) (for 0.1 hours)
8blood pHBN/NHsdMcwifemale7.4531air oxygen content (12 %) (for 0.1 hours)17092air oxygen content (12 %) (for 0.1 hours)
3blood pHBN/NHsdMcwimale7.5067air oxygen content (12 %) (for 0.1 hours)17612air oxygen content (12 %) (for 0.1 hours)
7blood pHBN/NHsdMcwifemale7.5air oxygen content (12 %) (for 0.1 hours)17613air oxygen content (12 %) (for 0.1 hours)
12absolute change in partial pressure of blood carbon dioxideBN/NHsdMcwimale-5.9417mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)20098resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
15absolute change in partial pressure of blood carbon dioxideBN/NHsdMcwifemale-6.3333mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)20099resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
17mean arterial blood pressureBN/NHsdMcwimale98.1671mmHgresting on treadmill (between 0.1 and 0.1 hours)20064resting on treadmill (between 0.1 and 0.1 hours)
17mean arterial blood pressureBN/NHsdMcwifemale96.2741mmHgresting on treadmill (between 0.1 and 0.1 hours)20065resting on treadmill (between 0.1 and 0.1 hours)
4blood pHBN/NHsdMcwimale7.455naive control condition20030naive control condition
7blood pHBN/NHsdMcwifemale7.4514naive control condition20031naive control condition
5partial pressure of blood oxygenBN/NHsdMcwimale121.54mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)19987resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
5partial pressure of blood oxygenBN/NHsdMcwifemale112.28mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)19988resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
3heart rateBN/NHsdMcwimale468.5567beats/minresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)19968resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
3heart rateBN/NHsdMcwifemale457.7833beats/minresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)19969resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
4absolute change in blood pHBN/NHsdMcwimale-0.0422resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)19930resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
5absolute change in blood pHBN/NHsdMcwifemale-0.0807resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)19931resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
8mean arterial blood pressureBN/NHsdMcwimale112.4812mmHgnaive control condition19907naive control condition
11mean arterial blood pressureBN/NHsdMcwifemale112.3282mmHgnaive control condition19908naive control condition
12absolute change in blood pHBN/NHsdMcwimale0.0652air oxygen content (12 %) (for 0.1 hours)19827air oxygen content (12 %) (for 0.1 hours)
8absolute change in blood pHBN/NHsdMcwifemale0.0366air oxygen content (12 %) (for 0.1 hours)19828air oxygen content (12 %) (for 0.1 hours)
9body temperatureBN/NHsdMcwimale37.8667degrees Cnaive control condition19753naive control condition
8body temperatureBN/NHsdMcwifemale38.25degrees Cnaive control condition19754naive control condition
1mean arterial blood pressureBN/NHsdMcwimale112.4mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)19711resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
5mean arterial blood pressureBN/NHsdMcwifemale102.398mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)19712resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
12absolute change in partial pressure of blood carbon dioxideBN/NHsdMcwimale-7.8542mmHgair oxygen content (12 %) (for 0.1 hours)19676air oxygen content (12 %) (for 0.1 hours)
8absolute change in partial pressure of blood carbon dioxideBN/NHsdMcwifemale-7.7625mmHgair oxygen content (12 %) (for 0.1 hours)19677air oxygen content (12 %) (for 0.1 hours)
9percent change in ventilationBN/NHsdMcwimale164.3221%air carbon dioxide content (7 %) (between 0 and 0.1 hours)19603air carbon dioxide content (7 %) (between 0 and 0.1 hours)
8percent change in ventilationBN/NHsdMcwifemale196.0897%air carbon dioxide content (7 %) (between 0 and 0.1 hours)19604air carbon dioxide content (7 %) (between 0 and 0.1 hours)
9absolute change in body temperatureBN/NHsdMcwimale-0.8degrees Cair oxygen content (12 %) (for 0.1 hours)19580air oxygen content (12 %) (for 0.1 hours)
8absolute change in body temperatureBN/NHsdMcwifemale-1.2degrees Cair oxygen content (12 %) (for 0.1 hours)19581air oxygen content (12 %) (for 0.1 hours)
2partial pressure of blood carbon dioxide (Pco2)BN/NHsdMcwimale33.675mmHgresting on treadmill (between 0.1 and 0.1 hours)19568resting on treadmill (between 0.1 and 0.1 hours)
5partial pressure of blood carbon dioxide (Pco2)BN/NHsdMcwifemale32.08mmHgresting on treadmill (between 0.1 and 0.1 hours)19569resting on treadmill (between 0.1 and 0.1 hours)
3partial pressure of blood oxygenBN/NHsdMcwimale48.85mmHgair oxygen content (12 %) (for 0.1 hours)19556air oxygen content (12 %) (for 0.1 hours)
7partial pressure of blood oxygenBN/NHsdMcwifemale50.8857mmHgair oxygen content (12 %) (for 0.1 hours)19557air oxygen content (12 %) (for 0.1 hours)
4partial pressure of blood oxygenBN/NHsdMcwimale100.1875mmHgnaive control condition19533naive control condition
7partial pressure of blood oxygenBN/NHsdMcwifemale101.9857mmHgnaive control condition19534naive control condition
3mean arterial blood pressureBN/NHsdMcwimale101.7133mmHgnaive control condition19521naive control condition
4mean arterial blood pressureBN/NHsdMcwifemale105.3425mmHgnaive control condition19522naive control condition
12absolute change in partial pressure of blood oxygenBN/NHsdMcwimale-43.7375mmHgair oxygen content (12 %) (for 0.1 hours)19507air oxygen content (12 %) (for 0.1 hours)
8absolute change in partial pressure of blood oxygenBN/NHsdMcwifemale-40.3mmHgair oxygen content (12 %) (for 0.1 hours)19508air oxygen content (12 %) (for 0.1 hours)
18respiration rateBN/NHsdMcwimale106.2087breaths/minair carbon dioxide content (7 %) (between 0 and 0.1 hours)16990air carbon dioxide content (7 %) (between 0 and 0.1 hours)
16respiration rateBN/NHsdMcwifemale112.995breaths/minair carbon dioxide content (7 %) (between 0 and 0.1 hours)16991air carbon dioxide content (7 %) (between 0 and 0.1 hours)
23body temperatureBN/NHsdMcwimale37.7522degrees Cnaive control condition16891naive control condition
18body temperatureBN/NHsdMcwifemale37.3444degrees Cnaive control condition16892naive control condition
3absolute change in mean arterial blood pressureBN/NHsdMcwimale14.73mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)16782resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
5absolute change in mean arterial blood pressureBN/NHsdMcwifemale11.566mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)16783resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
23minute ventilation (VE)BN/NHsdMcwimale23.007ml/minnaive control condition16769naive control condition
18minute ventilation (VE)BN/NHsdMcwifemale18.8589ml/minnaive control condition16770naive control condition
23body temperatureBN/NHsdMcwimale36.113degrees Cair oxygen content (12 %) (for 0.1 hours)16651air oxygen content (12 %) (for 0.1 hours)
18body temperatureBN/NHsdMcwifemale35.5556degrees Cair oxygen content (12 %) (for 0.1 hours)16652air oxygen content (12 %) (for 0.1 hours)
3partial pressure of blood carbon dioxide (Pco2)BN/NHsdMcwimale28.9167mmHgair oxygen content (12 %) (for 0.1 hours)16454air oxygen content (12 %) (for 0.1 hours)
7partial pressure of blood carbon dioxide (Pco2)BN/NHsdMcwifemale27.0786mmHgair oxygen content (12 %) (for 0.1 hours)16455air oxygen content (12 %) (for 0.1 hours)
16partial pressure of blood oxygenBN/NHsdMcwimale92.9906mmHgresting on treadmill (between 0.1 and 0.1 hours)16415resting on treadmill (between 0.1 and 0.1 hours)
17partial pressure of blood oxygenBN/NHsdMcwifemale96.3471mmHgresting on treadmill (between 0.1 and 0.1 hours)16416resting on treadmill (between 0.1 and 0.1 hours)
2absolute change in body temperatureBN/NHsdMcwimale0.55degrees Cresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours)16381resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (for 0.1 hours)
5absolute change in body temperatureBN/NHsdMcwifemale0.06degrees Cresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours)16382resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (for 0.1 hours)
3heart rateBN/NHsdMcwimale373.4367beats/minnaive control condition16358naive control condition
5heart rateBN/NHsdMcwifemale427.198beats/minnaive control condition16359naive control condition
9body temperatureBN/NHsdMcwimale36.5778degrees Cair carbon dioxide content (7 %) (for 0.1 hours)16334air carbon dioxide content (7 %) (for 0.1 hours)
8body temperatureBN/NHsdMcwifemale36.7375degrees Cair carbon dioxide content (7 %) (for 0.1 hours)16335air carbon dioxide content (7 %) (for 0.1 hours)
4absolute change in partial pressure of blood carbon dioxideBN/NHsdMcwimale-12.175mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)16322resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
5absolute change in partial pressure of blood carbon dioxideBN/NHsdMcwifemale-10.3mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)16323resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
12absolute change in partial pressure of blood oxygenBN/NHsdMcwimale19.85mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)16301resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
15absolute change in partial pressure of blood oxygenBN/NHsdMcwifemale10.7333mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)16302resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
9absolute change in body temperatureBN/NHsdMcwimale-1.2889degrees Cair carbon dioxide content (7 %) (for 0.1 hours)16267air carbon dioxide content (7 %) (for 0.1 hours)
8absolute change in body temperatureBN/NHsdMcwifemale-1.5125degrees Cair carbon dioxide content (7 %) (for 0.1 hours)16268air carbon dioxide content (7 %) (for 0.1 hours)
9minute ventilation (VE)BN/NHsdMcwimale43.6456ml/minair carbon dioxide content (7 %) (between 0.1 and 0.1 hours)16239air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
8minute ventilation (VE)BN/NHsdMcwifemale37.1375ml/minair carbon dioxide content (7 %) (between 0.1 and 0.1 hours)16240air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
18minute ventilation (VE)BN/NHsdMcwimale23.79ml/minnaive control condition16226naive control condition
16minute ventilation (VE)BN/NHsdMcwifemale19.9738ml/minnaive control condition16227naive control condition
14partial pressure of blood carbon dioxide (Pco2)BN/NHsdMcwimale39.9179mmHgnaive control condition16111naive control condition
10partial pressure of blood carbon dioxide (Pco2)BN/NHsdMcwifemale38.775mmHgnaive control condition16112naive control condition
18absolute change in body temperatureBN/NHsdMcwimale0.3556degrees Cresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours)16019resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (for 0.1 hours)
17absolute change in body temperatureBN/NHsdMcwifemale-0.0529degrees Cresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours)16020resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (for 0.1 hours)
1partial pressure of blood oxygenBN/NHsdMcwimale115mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)15983resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
5partial pressure of blood oxygenBN/NHsdMcwifemale115.33mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)15984resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
8heart rateBN/NHsdMcwimale271.0212beats/minnaive control condition15969naive control condition
11heart rateBN/NHsdMcwifemale294.9755beats/minnaive control condition15970naive control condition
18tidal volumeBN/NHsdMcwimale0.3894mlair carbon dioxide content (7 %) (between 0 and 0.1 hours)16552air carbon dioxide content (7 %) (between 0 and 0.1 hours)
16tidal volumeBN/NHsdMcwifemale0.3482mlair carbon dioxide content (7 %) (between 0 and 0.1 hours)16553air carbon dioxide content (7 %) (between 0 and 0.1 hours)
18absolute change in body temperatureBN/NHsdMcwimale-1.5333degrees Cair carbon dioxide content (7 %) (for 0.1 hours)15748air carbon dioxide content (7 %) (for 0.1 hours)
16absolute change in body temperatureBN/NHsdMcwifemale-2.1062degrees Cair carbon dioxide content (7 %) (for 0.1 hours)15749air carbon dioxide content (7 %) (for 0.1 hours)
1absolute change in partial pressure of blood carbon dioxideBN/NHsdMcwimale-7.65mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)15650resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
5absolute change in partial pressure of blood carbon dioxideBN/NHsdMcwifemale-8.24mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)15651resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
9minute ventilation (VE)BN/NHsdMcwimale30.7111ml/minnaive control condition15619naive control condition
8minute ventilation (VE)BN/NHsdMcwifemale23.8312ml/minnaive control condition15620naive control condition
5mean arterial blood pressureBN/NHsdMcwimale107.078mmHgnaive control condition15554naive control condition
7mean arterial blood pressureBN/NHsdMcwifemale102.2257mmHgnaive control condition15555naive control condition
1absolute change in mean arterial blood pressureBN/NHsdMcwimale13.06mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)15542resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
5absolute change in mean arterial blood pressureBN/NHsdMcwifemale9.55mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)15543resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
18tidal volumeBN/NHsdMcwimale0.2582mlnaive control condition15476naive control condition
16tidal volumeBN/NHsdMcwifemale0.2118mlnaive control condition15477naive control condition
9respiration rateBN/NHsdMcwimale107.9633breaths/minair oxygen content (12 %) (between 0.1 and 0.1 hours)15378air oxygen content (12 %) (between 0.1 and 0.1 hours)
8respiration rateBN/NHsdMcwifemale103.9762breaths/minair oxygen content (12 %) (between 0.1 and 0.1 hours)15379air oxygen content (12 %) (between 0.1 and 0.1 hours)
2absolute change in blood pHBN/NHsdMcwimale0.02resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)15355resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
5absolute change in blood pHBN/NHsdMcwifemale-0.008resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)15356resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
3heart rateBN/NHsdMcwimale283.6867beats/minair carbon dioxide content (7 %) (for 0.1 hours)15343air carbon dioxide content (7 %) (for 0.1 hours)
4heart rateBN/NHsdMcwifemale337.3075beats/minair carbon dioxide content (7 %) (for 0.1 hours)15344air carbon dioxide content (7 %) (for 0.1 hours)
18percent change in respiration rateBN/NHsdMcwimale117.9945%air carbon dioxide content (7 %) (between 0 and 0.1 hours)53644air carbon dioxide content (7 %) (between 0 and 0.1 hours)
16percent change in respiration rateBN/NHsdMcwifemale120.1812%air carbon dioxide content (7 %) (between 0 and 0.1 hours)53646air carbon dioxide content (7 %) (between 0 and 0.1 hours)
9percent change in respiration rateBN/NHsdMcwimale113.7752%air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)53558air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
8percent change in respiration rateBN/NHsdMcwifemale126.9101%air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)53562air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
9percent change in tidal volumeBN/NHsdMcwimale114.3989%air oxygen content (12 %) (between 0 and 0.1 hours)53546air oxygen content (12 %) (between 0 and 0.1 hours)
8percent change in tidal volumeBN/NHsdMcwifemale107.6174%air oxygen content (12 %) (between 0 and 0.1 hours)53550air oxygen content (12 %) (between 0 and 0.1 hours)
9percent change in tidal volumeBN/NHsdMcwimale137.969%air carbon dioxide content (7 %) (between 0 and 0.1 hours)53524air carbon dioxide content (7 %) (between 0 and 0.1 hours)
8percent change in tidal volumeBN/NHsdMcwifemale138.0548%air carbon dioxide content (7 %) (between 0 and 0.1 hours)53528air carbon dioxide content (7 %) (between 0 and 0.1 hours)
9percent change in respiration rateBN/NHsdMcwimale116.8993%air oxygen content (12 %) (between 0.1 and 0.1 hours)54558air oxygen content (12 %) (between 0.1 and 0.1 hours)
8percent change in respiration rateBN/NHsdMcwifemale122.062%air oxygen content (12 %) (between 0.1 and 0.1 hours)54562air oxygen content (12 %) (between 0.1 and 0.1 hours)
9percent change in tidal volumeBN/NHsdMcwimale99.8253%air oxygen content (12 %) (between 0.1 and 0.1 hours)54546air oxygen content (12 %) (between 0.1 and 0.1 hours)
8percent change in tidal volumeBN/NHsdMcwifemale102.192%air oxygen content (12 %) (between 0.1 and 0.1 hours)54550air oxygen content (12 %) (between 0.1 and 0.1 hours)
9percent change in respiration rateBN/NHsdMcwimale117.6828%air carbon dioxide content (7 %) (between 0 and 0.1 hours)54510air carbon dioxide content (7 %) (between 0 and 0.1 hours)
8percent change in respiration rateBN/NHsdMcwifemale142.0849%air carbon dioxide content (7 %) (between 0 and 0.1 hours)54514air carbon dioxide content (7 %) (between 0 and 0.1 hours)
18percent change in tidal volumeBN/NHsdMcwimale145.0234%air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)54435air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
16percent change in tidal volumeBN/NHsdMcwifemale157.8824%air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)54437air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
23percent change in respiration rateBN/NHsdMcwimale123.2681%air oxygen content (12 %) (between 0 and 0.1 hours)54336air oxygen content (12 %) (between 0 and 0.1 hours)
18percent change in respiration rateBN/NHsdMcwifemale134.1214%air oxygen content (12 %) (between 0 and 0.1 hours)54338air oxygen content (12 %) (between 0 and 0.1 hours)
18percent change in respiration rateBN/NHsdMcwimale124.8796%air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)54229air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
16percent change in respiration rateBN/NHsdMcwifemale123.1722%air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)54231air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
16percent change in tidal volumeBN/NHsdMcwifemale168.865%air carbon dioxide content (7 %) (between 0 and 0.1 hours)54097air carbon dioxide content (7 %) (between 0 and 0.1 hours)
18percent change in tidal volumeBN/NHsdMcwimale152.7086%air carbon dioxide content (7 %) (between 0 and 0.1 hours)54095air carbon dioxide content (7 %) (between 0 and 0.1 hours)
23percent change in tidal volumeBN/NHsdMcwimale109.618%air oxygen content (12 %) (between 0.1 and 0.1 hours)53996air oxygen content (12 %) (between 0.1 and 0.1 hours)
18percent change in tidal volumeBN/NHsdMcwifemale106.1867%air oxygen content (12 %) (between 0.1 and 0.1 hours)53998air oxygen content (12 %) (between 0.1 and 0.1 hours)
23percent change in tidal volumeBN/NHsdMcwimale117.2922%air oxygen content (12 %) (between 0 and 0.1 hours)53895air oxygen content (12 %) (between 0 and 0.1 hours)
18percent change in tidal volumeBN/NHsdMcwifemale118.5947%air oxygen content (12 %) (between 0 and 0.1 hours)53897air oxygen content (12 %) (between 0 and 0.1 hours)
9percent change in tidal volumeBN/NHsdMcwimale124.0548%air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)53840air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
8percent change in tidal volumeBN/NHsdMcwifemale122.4726%air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)53844air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
23percent change in respiration rateBN/NHsdMcwimale107.672%air oxygen content (12 %) (between 0.1 and 0.1 hours)53763air oxygen content (12 %) (between 0.1 and 0.1 hours)
18percent change in respiration rateBN/NHsdMcwifemale119.6734%air oxygen content (12 %) (between 0.1 and 0.1 hours)53765air oxygen content (12 %) (between 0.1 and 0.1 hours)
9percent change in respiration rateBN/NHsdMcwimale121.5997%air oxygen content (12 %) (between 0 and 0.1 hours)53727air oxygen content (12 %) (between 0 and 0.1 hours)
8percent change in respiration rateBN/NHsdMcwifemale136.0886%air oxygen content (12 %) (between 0 and 0.1 hours)53731air oxygen content (12 %) (between 0 and 0.1 hours)
13heart rateBN/NHsdMcwimale264.7108beats/minnaive control condition20965naive control condition
14heart rateBN/NHsdMcwifemale318.4143beats/minnaive control condition20966naive control condition
4absolute change in partial pressure of blood oxygenBN/NHsdMcwimale26.6mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)20883resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
5absolute change in partial pressure of blood oxygenBN/NHsdMcwifemale6.7mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)20884resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
2blood pHBN/NHsdMcwimale7.455resting on treadmill (for 0.1 hours)20862resting on treadmill (for 0.1 hours)
5blood pHBN/NHsdMcwifemale7.464resting on treadmill (for 0.1 hours)20863resting on treadmill (for 0.1 hours)
16blood pHBN/NHsdMcwimale7.4578resting on treadmill (for 0.1 hours)20170resting on treadmill (for 0.1 hours)
17blood pHBN/NHsdMcwifemale7.4621resting on treadmill (for 0.1 hours)20171resting on treadmill (for 0.1 hours)
5blood pHBN/NHsdMcwimale7.4086resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours)19743resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (for 0.1 hours)
5blood pHBN/NHsdMcwifemale7.3682resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours)19744resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (for 0.1 hours)
1blood pHBN/NHsdMcwimale7.51resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours)19019resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (for 0.1 hours)
5blood pHBN/NHsdMcwifemale7.44resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours)19020resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (for 0.1 hours)
18minute ventilation (VE)BN/NHsdMcwimale41.7377ml/minair carbon dioxide content (7 %) (between 0.1 and 0.1 hours)20840air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
16minute ventilation (VE)BN/NHsdMcwifemale37.1656ml/minair carbon dioxide content (7 %) (between 0.1 and 0.1 hours)20841air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
13absolute change in mean arterial blood pressureBN/NHsdMcwimale25.2846mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)20742resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
15absolute change in mean arterial blood pressureBN/NHsdMcwifemale15.462mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)20743resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
9minute ventilation (VE)BN/NHsdMcwimale33.17ml/minair oxygen content (12 %) (between 0.1 and 0.1 hours)20706air oxygen content (12 %) (between 0.1 and 0.1 hours)
8minute ventilation (VE)BN/NHsdMcwifemale29.4375ml/minair oxygen content (12 %) (between 0.1 and 0.1 hours)20707air oxygen content (12 %) (between 0.1 and 0.1 hours)
9respiration rateBN/NHsdMcwimale113.5544breaths/minair carbon dioxide content (7 %) (between 0 and 0.1 hours)20681air carbon dioxide content (7 %) (between 0 and 0.1 hours)
8respiration rateBN/NHsdMcwifemale118.145breaths/minair carbon dioxide content (7 %) (between 0 and 0.1 hours)20682air carbon dioxide content (7 %) (between 0 and 0.1 hours)
14blood pHBN/NHsdMcwimale7.4028naive control condition20666naive control condition
10blood pHBN/NHsdMcwifemale7.4187naive control condition20667naive control condition
13blood pHBN/NHsdMcwimale7.4807resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours)14614resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)
15blood pHBN/NHsdMcwifemale7.4681resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours)14615resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)
2blood pHBN/NHsdMcwimale7.475resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours)14156resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)
5blood pHBN/NHsdMcwifemale7.456resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours)14157resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)
2absolute change in partial pressure of blood carbon dioxideBN/NHsdMcwimale-5.275mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)20592resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
5absolute change in partial pressure of blood carbon dioxideBN/NHsdMcwifemale-5.17mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)20593resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
23tidal volumeBN/NHsdMcwimale0.279mlair oxygen content (12 %) (between 0.1 and 0.1 hours)15312air oxygen content (12 %) (between 0.1 and 0.1 hours)
18tidal volumeBN/NHsdMcwifemale0.2305mlair oxygen content (12 %) (between 0.1 and 0.1 hours)15313air oxygen content (12 %) (between 0.1 and 0.1 hours)
2absolute change in partial pressure of blood oxygenBN/NHsdMcwimale5.7mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)15187resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
5absolute change in partial pressure of blood oxygenBN/NHsdMcwifemale10.92mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)15188resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours)
3absolute change in mean arterial blood pressureBN/NHsdMcwimale22.1067mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)15159resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
3absolute change in mean arterial blood pressureBN/NHsdMcwifemale25.7533mmHgresting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)15160resting on treadmill (for 0.1 hours)walking on treadmill (0.8 m/min) (for 0.1 hours)running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours)
24time to peak heart contractionBN/NHsdMcwimale1126.0858sair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours)50304air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)
23time to peak heart contractionBN/NHsdMcwifemale1201.3987sair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours)50305air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)
19time to onset of heart contractionBN/NHsdMcwimale899.0489scontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours)50197controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)
17time to onset of heart contractionBN/NHsdMcwifemale867.0953scontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours)50198controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)
24heart contraction pressureBN/NHsdMcwimale43.875mmHgair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours)50074air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)
23heart contraction pressureBN/NHsdMcwifemale33.8261mmHgair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours)50075air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)
24left ventricular systolic blood pressureBN/NHsdMcwimale110.805mmHgair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)49965air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
23left ventricular systolic blood pressureBN/NHsdMcwifemale101.6109mmHgair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)49966air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
9heart effluent lactate dehydrogenase activity level normalized to heart weightBN/NHsdMcwimale7.3929IU/gcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)49846controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
8heart effluent lactate dehydrogenase activity level normalized to heart weightBN/NHsdMcwifemale7.2252IU/gcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)49847controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
24heart left ventricle infarction weight to total heart left ventricle weight ratioBN/NHsdMcwimale6.2575%air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours)49775air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 3 hours)
23heart left ventricle infarction weight to total heart left ventricle weight ratioBN/NHsdMcwifemale4.3135%air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours)49776air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 3 hours)
24body weightBN/NHsdMcwimale163.8gair oxygen content (12 %) (for 14 days)49580air oxygen content (12 %) (for 14 days)
23body weightBN/NHsdMcwifemale115gair oxygen content (12 %) (for 14 days)49581air oxygen content (12 %) (for 14 days)
17heart left ventricle infarction weight to total heart left ventricle weight ratioBN/NHsdMcwimale3.1235%controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours)49474controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 3 hours)
18heart left ventricle infarction weight to total heart left ventricle weight ratioBN/NHsdMcwifemale2.2867%controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours)49475controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 3 hours)
24time to onset of heart contractionBN/NHsdMcwimale875.8479sair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours)49376air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)
23time to onset of heart contractionBN/NHsdMcwifemale931.6861sair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours)49377air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)
19left ventricular diastolic blood pressureBN/NHsdMcwimale5.5142mmHgcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours)49255controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
17left ventricular diastolic blood pressureBN/NHsdMcwifemale5.5059mmHgcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours)49256controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
20heart wet weightBN/NHsdMcwimale0.7145gnaive control condition49138naive control condition
19heart wet weightBN/NHsdMcwifemale0.54gnaive control condition49139naive control condition
18heart rateBN/NHsdMcwimale225.7722beats/mincontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)49023controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
18heart rateBN/NHsdMcwifemale211.1867beats/mincontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)49024controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
24percent change in left ventricular systolic blood pressureBN/NHsdMcwimale78.2218%air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)48833air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
22percent change in left ventricular systolic blood pressureBN/NHsdMcwifemale76.2438%air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)48834air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
22percent change in left ventricular developed pressureBN/NHsdMcwimale52.6286%air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)48604air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
22percent change in left ventricular developed pressureBN/NHsdMcwifemale55.2943%air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)48605air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
22left ventricular developed pressureBN/NHsdMcwimale140.9309mmHgair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours)48701air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
22left ventricular developed pressureBN/NHsdMcwifemale128.1623mmHgair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours)48702air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
19percent change in heart rateBN/NHsdMcwimale83.6129%controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)48484controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
17percent change in heart rateBN/NHsdMcwifemale80.0496%controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)48485controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
24percent change in heart rateBN/NHsdMcwimale94.7936%air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)48372air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
23percent change in heart rateBN/NHsdMcwifemale86.825%air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)48373air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
19heart rateBN/NHsdMcwimale260.7379beats/mincontrolled oxygen content Kreb's solution perfusate (for 0.5 hours)48275controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
17heart rateBN/NHsdMcwifemale240.9871beats/mincontrolled oxygen content Kreb's solution perfusate (for 0.5 hours)48276controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
19heart contraction pressureBN/NHsdMcwimale42.1053mmHgcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours)48111controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)
17heart contraction pressureBN/NHsdMcwifemale43mmHgcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours)48112controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)
18left ventricular developed pressureBN/NHsdMcwimale70.5322mmHgcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)47989controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
18left ventricular developed pressureBN/NHsdMcwifemale69.325mmHgcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)47990controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
20body weightBN/NHsdMcwimale168.7gnaive control condition47875naive control condition
19body weightBN/NHsdMcwifemale120.6gnaive control condition47876naive control condition
18left ventricular diastolic blood pressureBN/NHsdMcwimale38.9144mmHgcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)47779controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
18left ventricular diastolic blood pressureBN/NHsdMcwifemale33.6567mmHgcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)47780controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
24heart rateBN/NHsdMcwimale247.2225beats/minair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours)47659air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
23heart rateBN/NHsdMcwifemale264.6109beats/minair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours)47660air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
19heart effluent lactate dehydrogenase activity level normalized to heart weightBN/NHsdMcwimale0.7807IU/gair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours)47505air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
19heart effluent lactate dehydrogenase activity level normalized to heart weightBN/NHsdMcwifemale0.7265IU/gair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours)47506air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
16heart effluent lactate dehydrogenase activity level normalized to heart weightBN/NHsdMcwimale0.6076IU/gcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours)47367controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
16heart effluent lactate dehydrogenase activity level normalized to heart weightBN/NHsdMcwifemale0.6072IU/gcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours)47368controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
24left ventricular diastolic blood pressureBN/NHsdMcwimale5.4475mmHgair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours)47274air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
23left ventricular diastolic blood pressureBN/NHsdMcwifemale5.4391mmHgair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours)47275air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
23percent change in arterial blood flow rateBN/NHsdMcwimale55.1772%air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)47154air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
21percent change in arterial blood flow rateBN/NHsdMcwifemale57.273%air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)47155air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
20heart weight to body weight ratioBN/NHsdMcwimale4.25g/kgnaive control condition47053naive control condition
19heart weight to body weight ratioBN/NHsdMcwifemale4.505g/kgnaive control condition47054naive control condition
18arterial blood flow rateBN/NHsdMcwimale14.3906ml/min/gcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours)46947controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
18arterial blood flow rateBN/NHsdMcwifemale14.6844ml/min/gcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours)46948controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
17left ventricular developed pressureBN/NHsdMcwimale136.8953mmHgcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours)46828controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
15left ventricular developed pressureBN/NHsdMcwifemale124.3173mmHgcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours)46829controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
22arterial blood flow rateBN/NHsdMcwimale17.8086ml/min/gair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours)46730air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
21arterial blood flow rateBN/NHsdMcwifemale16.3214ml/min/gair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours)46731air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
19time to peak heart contractionBN/NHsdMcwimale1266.1547scontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours)46626controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)
17time to peak heart contractionBN/NHsdMcwifemale1122.0124scontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours)46627controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)
24left ventricular diastolic blood pressureBN/NHsdMcwimale39.1583mmHgair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)46494air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
21left ventricular diastolic blood pressureBN/NHsdMcwifemale32.9071mmHgair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)46495air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
17percent change in left ventricular developed pressureBN/NHsdMcwimale48.9442%controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)46397controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
15percent change in left ventricular developed pressureBN/NHsdMcwifemale51.1247%controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)46398controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
18arterial blood flow rateBN/NHsdMcwimale8.3872ml/min/gcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)46279controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
18arterial blood flow rateBN/NHsdMcwifemale10.6078ml/min/gcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)46280controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
18percent change in arterial blood flow rateBN/NHsdMcwimale54.0471%controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)46143controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
19percent change in arterial blood flow rateBN/NHsdMcwifemale62.6615%controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)46144controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
4heart effluent lactate dehydrogenase activity level normalized to heart weightBN/NHsdMcwimale40.4894IU/gair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours)46011air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 1.5 hours)
3heart effluent lactate dehydrogenase activity level normalized to heart weightBN/NHsdMcwifemale34.5106IU/gair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours)46012air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 1.5 hours)
22left ventricular systolic blood pressureBN/NHsdMcwimale146.4268mmHgair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours)45806air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
22left ventricular systolic blood pressureBN/NHsdMcwifemale135.4173mmHgair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours)45807air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
10heart effluent lactate dehydrogenase activity level normalized to heart weightBN/NHsdMcwimale11.4842IU/gair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)45710air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
10heart effluent lactate dehydrogenase activity level normalized to heart weightBN/NHsdMcwifemale9.6919IU/gair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)45711air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
24heart weight to body weight ratioBN/NHsdMcwimale4.534g/kgair oxygen content (12 %) (for 14 days)45678air oxygen content (12 %) (for 14 days)
23heart weight to body weight ratioBN/NHsdMcwifemale5.163g/kgair oxygen content (12 %) (for 14 days)45679air oxygen content (12 %) (for 14 days)
17left ventricular systolic blood pressureBN/NHsdMcwimale142.4994mmHgcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours)45582controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
15left ventricular systolic blood pressureBN/NHsdMcwifemale131.0973mmHgcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours)45583controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
24heart wet weightBN/NHsdMcwimale0.7442gair oxygen content (12 %) (for 14 days)45482air oxygen content (12 %) (for 14 days)
23heart wet weightBN/NHsdMcwifemale0.5926gair oxygen content (12 %) (for 14 days)45483air oxygen content (12 %) (for 14 days)
24left ventricular developed pressureBN/NHsdMcwimale71.055mmHgair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)45347air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
22left ventricular developed pressureBN/NHsdMcwifemale73.7864mmHgair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)45348air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
24heart rateBN/NHsdMcwimale222.9096beats/minair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)45225air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
23heart rateBN/NHsdMcwifemale227.2791beats/minair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)45226air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
17percent change in left ventricular systolic blood pressureBN/NHsdMcwimale73.0919%controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)44996controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
15percent change in left ventricular systolic blood pressureBN/NHsdMcwifemale77.6849%controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)44997controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
18left ventricular systolic blood pressureBN/NHsdMcwimale108.9739mmHgcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)44893controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
18left ventricular systolic blood pressureBN/NHsdMcwifemale107.5489mmHgcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)44894controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
24arterial blood flow rateBN/NHsdMcwimale10.0162ml/min/gair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)44795air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
23arterial blood flow rateBN/NHsdMcwifemale9.4178ml/min/gair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)44796air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
10urine potassium excretion rateBN/NHsdMcwimale1.4657mEq/dcontrolled sodium content diet (8 %) (between 19 and 22 days)52972controlled sodium content diet (8 %) (between 19 and 22 days)
21urine potassium excretion rateBN/NHsdMcwifemale0.953mEq/dcontrolled sodium content diet (8 %) (between 19 and 22 days)52973controlled sodium content diet (8 %) (between 19 and 22 days)
8plasma renin activity levelBN/NHsdMcwimale0.26ng/ml/hcontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52918controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
7plasma renin activity levelBN/NHsdMcwifemale1.6086ng/ml/hcontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52919controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
9mean arterial blood pressureBN/NHsdMcwimale110.8374mmHgcontrolled sodium content diet (8 %) (between 19 and 22 days)52874controlled sodium content diet (8 %) (between 19 and 22 days)
18mean arterial blood pressureBN/NHsdMcwifemale112.4861mmHgcontrolled sodium content diet (8 %) (between 19 and 22 days)52875controlled sodium content diet (8 %) (between 19 and 22 days)
8urine sodium excretion rateBN/NHsdMcwimale19.0701mEq/dcontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52820controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
11urine sodium excretion rateBN/NHsdMcwifemale15.9886mEq/dcontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52821controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
10urine sodium excretion rateBN/NHsdMcwimale25.204mEq/dcontrolled sodium content diet (8 %) (between 19 and 22 days)52776controlled sodium content diet (8 %) (between 19 and 22 days)
21urine sodium excretion rateBN/NHsdMcwifemale15.5679mEq/dcontrolled sodium content diet (8 %) (between 19 and 22 days)52777controlled sodium content diet (8 %) (between 19 and 22 days)
10urine total protein excretion rateBN/NHsdMcwimale73.2518mg/dcontrolled sodium content diet (8 %) (between 19 and 22 days)52725controlled sodium content diet (8 %) (between 19 and 22 days)
21urine total protein excretion rateBN/NHsdMcwifemale34.789mg/dcontrolled sodium content diet (8 %) (between 19 and 22 days)52726controlled sodium content diet (8 %) (between 19 and 22 days)
9heart rateBN/NHsdMcwimale363.5598beats/mincontrolled sodium content diet (8 %) (between 19 and 22 days)52676controlled sodium content diet (8 %) (between 19 and 22 days)
18heart rateBN/NHsdMcwifemale384.4982beats/mincontrolled sodium content diet (8 %) (between 19 and 22 days)52677controlled sodium content diet (8 %) (between 19 and 22 days)
10urine albumin excretion rateBN/NHsdMcwimale4.0456mg/dcontrolled sodium content diet (8 %) (between 19 and 22 days)52625controlled sodium content diet (8 %) (between 19 and 22 days)
21urine albumin excretion rateBN/NHsdMcwifemale2.1645mg/dcontrolled sodium content diet (8 %) (between 19 and 22 days)52626controlled sodium content diet (8 %) (between 19 and 22 days)
8mean arterial blood pressureBN/NHsdMcwimale120.8359mmHgcontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52571controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
8mean arterial blood pressureBN/NHsdMcwifemale126.2761mmHgcontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52572controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
8heart rateBN/NHsdMcwimale349.7154beats/mincontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52524controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
8heart rateBN/NHsdMcwifemale394.1856beats/mincontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52525controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
8plasma renin activity levelBN/NHsdMcwimale1.015ng/ml/hcontrolled sodium content diet (8 %) (between 19 and 22 days)52480controlled sodium content diet (8 %) (between 19 and 22 days)
15plasma renin activity levelBN/NHsdMcwifemale4.3973ng/ml/hcontrolled sodium content diet (8 %) (between 19 and 22 days)52481controlled sodium content diet (8 %) (between 19 and 22 days)
8urine albumin excretion rateBN/NHsdMcwimale5.4077mg/dcontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52426controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
11urine albumin excretion rateBN/NHsdMcwifemale7.1637mg/dcontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52427controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
8creatinine clearanceBN/NHsdMcwimale2.5544ml/mincontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52379controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
7creatinine clearanceBN/NHsdMcwifemale1.2284ml/mincontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52380controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
8urine potassium excretion rateBN/NHsdMcwimale1.0626mEq/dcontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52332controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
11urine potassium excretion rateBN/NHsdMcwifemale0.7679mEq/dcontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52333controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
8plasma creatinine levelBN/NHsdMcwimale0.2413mg/dlcontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52283controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
7plasma creatinine levelBN/NHsdMcwifemale0.325mg/dlcontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52284controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
8creatinine clearanceBN/NHsdMcwimale1.7438ml/mincontrolled sodium content diet (8 %) (between 19 and 22 days)52186controlled sodium content diet (8 %) (between 19 and 22 days)
15creatinine clearanceBN/NHsdMcwifemale1.134ml/mincontrolled sodium content diet (8 %) (between 19 and 22 days)52187controlled sodium content diet (8 %) (between 19 and 22 days)
8urine total protein excretion rateBN/NHsdMcwimale32.2531mg/dcontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52134controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
11urine total protein excretion rateBN/NHsdMcwifemale39.4259mg/dcontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52135controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
8plasma creatinine levelBN/NHsdMcwimale0.4106mg/dlcontrolled sodium content diet (8 %) (between 19 and 22 days)52235controlled sodium content diet (8 %) (between 19 and 22 days)
15plasma creatinine levelBN/NHsdMcwifemale0.3497mg/dlcontrolled sodium content diet (8 %) (between 19 and 22 days)52236controlled sodium content diet (8 %) (between 19 and 22 days)
12methylene blue metabolism-surface area product after auto-oxidationBN/NHsdMcwimale9.9308ml/min/kgmethylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours)60065methylene blue (10 umol/l) (between 0 and 0 hours)sample resting period (for 0.1 hours)
15methylene blue metabolism-surface area product after auto-oxidationBN/NHsdMcwifemale11.3013ml/min/kgmethylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours)60066methylene blue (10 umol/l) (between 0 and 0 hours)sample resting period (for 0.1 hours)
15calculated pulmonary vascular resistance normalized to body weightBN/NHsdMcwimale0.1019mmHg x min x kg x ml-1Kreb's solution perfusate (between 0.2 and 0.2 hours)59959Kreb's solution perfusate (between 0.2 and 0.2 hours)
15calculated pulmonary vascular resistance normalized to body weightBN/NHsdMcwifemale0.0988mmHg x min x kg x ml-1Kreb's solution perfusate (between 0.2 and 0.2 hours)59960Kreb's solution perfusate (between 0.2 and 0.2 hours)
12methylene blue to FAPGG metabolism-surface area product ratioBN/NHsdMcwimale0.231methylene blue (10 umol/l) (between 0 and 0 hours)59843methylene blue (10 umol/l) (between 0 and 0 hours)
15methylene blue to FAPGG metabolism-surface area product ratioBN/NHsdMcwifemale0.2247methylene blue (10 umol/l) (between 0 and 0 hours)59844methylene blue (10 umol/l) (between 0 and 0 hours)
32lung dry weight to body weight ratioBN/NHsdMcwimale1.3412g/kgair oxygen content (12 %) (for 14 days)59735air oxygen content (12 %) (for 14 days)
32lung dry weight to body weight ratioBN/NHsdMcwifemale1.5683g/kgair oxygen content (12 %) (for 14 days)59736air oxygen content (12 %) (for 14 days)
28calculated pulmonary vascular resistance normalized to body weightBN/NHsdMcwimale0.1327mmHg x min x kg x ml-1air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours)59625air oxygen content (12 %) (for 14 days)Kreb's solution perfusate (between 0.2 and 0.2 hours)
29calculated pulmonary vascular resistance normalized to body weightBN/NHsdMcwifemale0.1242mmHg x min x kg x ml-1air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours)59626air oxygen content (12 %) (for 14 days)Kreb's solution perfusate (between 0.2 and 0.2 hours)
20lung dry weight to body weight ratioBN/NHsdMcwimale1.0437g/kgnaive control condition (for 14 days)59525naive control condition (for 14 days)
20lung dry weight to body weight ratioBN/NHsdMcwifemale1.5576g/kgnaive control condition (for 14 days)59526naive control condition (for 14 days)
15fractional change in blood vessel diameter per unit change in intravascular pressureBN/NHsdMcwimale0.0604mmHg-1Kreb's solution perfusate (between 0.2 and 0.2 hours)59429Kreb's solution perfusate (between 0.2 and 0.2 hours)
15fractional change in blood vessel diameter per unit change in intravascular pressureBN/NHsdMcwifemale0.0489mmHg-1Kreb's solution perfusate (between 0.2 and 0.2 hours)59430Kreb's solution perfusate (between 0.2 and 0.2 hours)
20hematocritBN/NHsdMcwimale55.485%air oxygen content (12 %) (for 14 days)59335air oxygen content (12 %) (for 14 days)
17hematocritBN/NHsdMcwifemale54.0529%air oxygen content (12 %) (for 14 days)59336air oxygen content (12 %) (for 14 days)
16dose of methacholine at which pulmonary conductance is half its pretreatment value (ED50)BN/NHsdMcwimale1.4389mg/kgmethacholine (0~11.06 mg/kg) and drug dose time series (for 0.2 hours)59235methacholine (0~11.06 mg/kg) drug dose time series (for 0.2 hours)
14dose of methacholine at which pulmonary conductance is half its pretreatment value (ED50)BN/NHsdMcwifemale1.7337mg/kgmethacholine (0~11.06 mg/kg) and drug dose time series (for 0.2 hours)59236methacholine (0~11.06 mg/kg) drug dose time series (for 0.2 hours)
32body weightBN/NHsdMcwimale189.6gair oxygen content (12 %) (for 14 days)59140air oxygen content (12 %) (for 14 days)
32body weightBN/NHsdMcwifemale133.1gair oxygen content (12 %) (for 14 days)59141air oxygen content (12 %) (for 14 days)
18dose of methacholine at which pulmonary conductance is half its pretreatment value (ED50)BN/NHsdMcwimale1.4444mg/kgair oxygen content (12 %) (for 14 days) then methacholine (0~11.06 mg/kg) and drug dose time series (for 0.2 hours)58984air oxygen content (12 %) (for 14 days)methacholine (0~11.06 mg/kg) drug dose time series (for 0.2 hours)
19dose of methacholine at which pulmonary conductance is half its pretreatment value (ED50)BN/NHsdMcwifemale2.9678mg/kgair oxygen content (12 %) (for 14 days) then methacholine (0~11.06 mg/kg) and drug dose time series (for 0.2 hours)58985air oxygen content (12 %) (for 14 days)methacholine (0~11.06 mg/kg) drug dose time series (for 0.2 hours)
32heart right ventricle weight to left ventricle weight ratioBN/NHsdMcwimale0.3593air oxygen content (12 %) (for 14 days)58811air oxygen content (12 %) (for 14 days)
32heart right ventricle weight to left ventricle weight ratioBN/NHsdMcwifemale0.3169air oxygen content (12 %) (for 14 days)58812air oxygen content (12 %) (for 14 days)
12methylene blue metabolism-surface area product without auto-oxidationBN/NHsdMcwimale13.5468ml/min/kgmethylene blue (10 umol/l) (between 0 and 0 hours)58694methylene blue (10 umol/l) (between 0 and 0 hours)
15methylene blue metabolism-surface area product without auto-oxidationBN/NHsdMcwifemale15.3279ml/min/kgmethylene blue (10 umol/l) (between 0 and 0 hours)58695methylene blue (10 umol/l) (between 0 and 0 hours)
28fractional change in blood vessel diameter per unit change in intravascular pressureBN/NHsdMcwimale0.0317mmHg-1air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours)58567air oxygen content (12 %) (for 14 days)Kreb's solution perfusate (between 0.2 and 0.2 hours)
29fractional change in blood vessel diameter per unit change in intravascular pressureBN/NHsdMcwifemale0.0292mmHg-1air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours)58568air oxygen content (12 %) (for 14 days)Kreb's solution perfusate (between 0.2 and 0.2 hours)
20body weightBN/NHsdMcwimale211.5gnaive control condition (for 14 days)58409naive control condition (for 14 days)
20body weightBN/NHsdMcwifemale138.3gnaive control condition (for 14 days)58410naive control condition (for 14 days)
13FAPGG metabolism-surface area productBN/NHsdMcwimale57.0935ml/min/kgFAPGG (0.6 mmol/l) (between 0 and 0 hours)58297FAPGG (0.6 mmol/l) (between 0 and 0 hours)
15FAPGG metabolism-surface area productBN/NHsdMcwifemale65.7949ml/min/kgFAPGG (0.6 mmol/l) (between 0 and 0 hours)58298FAPGG (0.6 mmol/l) (between 0 and 0 hours)
24methylene blue to FAPGG metabolism-surface area product ratioBN/NHsdMcwimale0.4588air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours)58191air oxygen content (12 %) (for 14 days)methylene blue (10 umol/l) (between 0 and 0 hours)
24methylene blue to FAPGG metabolism-surface area product ratioBN/NHsdMcwifemale0.4193air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours)58192air oxygen content (12 %) (for 14 days)methylene blue (10 umol/l) (between 0 and 0 hours)
28FAPGG metabolism-surface area productBN/NHsdMcwimale49.2855ml/min/kgair oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours)58077air oxygen content (12 %) (for 14 days)FAPGG (0.6 mmol/l) (between 0 and 0 hours)
26FAPGG metabolism-surface area productBN/NHsdMcwifemale66.4532ml/min/kgair oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours)58078air oxygen content (12 %) (for 14 days)FAPGG (0.6 mmol/l) (between 0 and 0 hours)
20heart right ventricle weight to left ventricle weight ratioBN/NHsdMcwimale0.1952naive control condition (for 14 days)57972naive control condition (for 14 days)
19heart right ventricle weight to left ventricle weight ratioBN/NHsdMcwifemale0.2091naive control condition (for 14 days)57973naive control condition (for 14 days)
24methylene blue metabolism-surface area product without auto-oxidationBN/NHsdMcwimale22.4305ml/min/kgair oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours)57878air oxygen content (12 %) (for 14 days)methylene blue (10 umol/l) (between 0 and 0 hours)
27methylene blue metabolism-surface area product without auto-oxidationBN/NHsdMcwifemale27.5929ml/min/kgair oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours)57879air oxygen content (12 %) (for 14 days)methylene blue (10 umol/l) (between 0 and 0 hours)
24methylene blue metabolism-surface area product after auto-oxidationBN/NHsdMcwimale16.7347ml/min/kgair oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours)57676air oxygen content (12 %) (for 14 days)methylene blue (10 umol/l) (between 0 and 0 hours)sample resting period (for 0.1 hours)
27methylene blue metabolism-surface area product after auto-oxidationBN/NHsdMcwifemale20.6413ml/min/kgair oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours)57677air oxygen content (12 %) (for 14 days)methylene blue (10 umol/l) (between 0 and 0 hours)sample resting period (for 0.1 hours)
18hematocritBN/NHsdMcwimale45.1889%naive control condition (for 14 days)57558naive control condition (for 14 days)
11hematocritBN/NHsdMcwifemale44.0364%naive control condition (for 14 days)57559naive control condition (for 14 days)
18concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)BN/NHsdMcwimale3.0989E-7molecontrolled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0~30 umol/l) and drug dose time series (for 1 hours)56580controlled sodium content diet (4 %) (for 21 days)phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0~30 umol/l) drug dose time series (for 1 hours)
20concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)BN/NHsdMcwifemale1.8894E-7molecontrolled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0~30 umol/l) and drug dose time series (for 1 hours)56581controlled sodium content diet (4 %) (for 21 days)phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0~30 umol/l) drug dose time series (for 1 hours)
19sodium nitroprusside-induced blood vessel dilation expressed as percent of force at maximum constrictionBN/NHsdMcwimale99.3684%phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0~3 umol/l) and drug dose time series (for 1 hours)56487phenylephrine (1 umol/l) (for 0.2 hours)sodium nitroprusside (0~3 umol/l) drug dose time series (for 1 hours)
20sodium nitroprusside-induced blood vessel dilation expressed as percent of force at maximum constrictionBN/NHsdMcwifemale98.45%phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0~3 umol/l) and drug dose time series (for 1 hours)56488phenylephrine (1 umol/l) (for 0.2 hours)sodium nitroprusside (0~3 umol/l) drug dose time series (for 1 hours)
20maximum contractile force per wet weight of aortaBN/NHsdMcwimale1.906g/mgcontrolled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours)57394controlled sodium content diet (4 %) (for 21 days)potassium ion (80 mmol/l) (for 0.2 hours)phenylephrine (10 umol/l) (for 0.2 hours)
24maximum contractile force per wet weight of aortaBN/NHsdMcwifemale2.3454g/mgcontrolled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours)57395controlled sodium content diet (4 %) (for 21 days)potassium ion (80 mmol/l) (for 0.2 hours)phenylephrine (10 umol/l) (for 0.2 hours)
18acetylcholine-induced blood vessel dilation expressed as percent of force at maximum constrictionBN/NHsdMcwimale61.9444%phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0~30 umol/l) and drug dose time series (for 1 hours)57286phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0~30 umol/l) drug dose time series (for 1 hours)
18acetylcholine-induced blood vessel dilation expressed as percent of force at maximum constrictionBN/NHsdMcwifemale62.6667%phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0~30 umol/l) and drug dose time series (for 1 hours)57287phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0~30 umol/l) drug dose time series (for 1 hours)
17hypoxia-induced blood vessel dilation expressed as percent of force at maximum constrictionBN/NHsdMcwimale45.8235%phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours)57189phenylephrine (1 umol/l) controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours)controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours)controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours)controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours)
14hypoxia-induced blood vessel dilation expressed as percent of force at maximum constrictionBN/NHsdMcwifemale40.7143%phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours)57190phenylephrine (1 umol/l) controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours)controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours)controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours)controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours)
7hypoxia-induced blood vessel dilation expressed as percent of force at maximum constrictionBN/NHsdMcwimale43.7729%controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours)57158controlled sodium content diet (4 %) (for 21 days)phenylephrine (1 umol/l) controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours)controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours)controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours)controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours)
6hypoxia-induced blood vessel dilation expressed as percent of force at maximum constrictionBN/NHsdMcwifemale47.5%controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours)57159controlled sodium content diet (4 %) (for 21 days)phenylephrine (1 umol/l) controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours)controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours)controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours)controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours)
18logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)BN/NHsdMcwimale-6.6659controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0~30 umol/l) and drug dose time series (for 1 hours)56975controlled sodium content diet (4 %) (for 21 days)phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0~30 umol/l) drug dose time series (for 1 hours)
20logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)BN/NHsdMcwifemale-6.8744controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0~30 umol/l) and drug dose time series (for 1 hours)56976controlled sodium content diet (4 %) (for 21 days)phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0~30 umol/l) drug dose time series (for 1 hours)
18concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)BN/NHsdMcwimale2.0605E-7molephenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0~30 umol/l) and drug dose time series (for 1 hours)55956phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0~30 umol/l) drug dose time series (for 1 hours)
18concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)BN/NHsdMcwifemale1.3467E-7molephenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0~30 umol/l) and drug dose time series (for 1 hours)55957phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0~30 umol/l) drug dose time series (for 1 hours)
20maximum contractile force per wet weight of aortaBN/NHsdMcwimale2.2525g/mgpotassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours)55850potassium ion (80 mmol/l) (for 0.2 hours)phenylephrine (10 umol/l) (for 0.2 hours)
20maximum contractile force per wet weight of aortaBN/NHsdMcwifemale2.4645g/mgpotassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours)55851potassium ion (80 mmol/l) (for 0.2 hours)phenylephrine (10 umol/l) (for 0.2 hours)
19concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)BN/NHsdMcwimale0.025910E-7mol/lphenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0~3 umol/l) and drug dose time series (for 1 hours)55757phenylephrine (1 umol/l) (for 0.2 hours)sodium nitroprusside (0~3 umol/l) drug dose time series (for 1 hours)
20concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)BN/NHsdMcwifemale0.017510E-7mol/lphenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0~3 umol/l) and drug dose time series (for 1 hours)55758phenylephrine (1 umol/l) (for 0.2 hours)sodium nitroprusside (0~3 umol/l) drug dose time series (for 1 hours)
18logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)BN/NHsdMcwimale-6.7953phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0~30 umol/l) and drug dose time series (for 1 hours)55687phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0~30 umol/l) drug dose time series (for 1 hours)
18logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)BN/NHsdMcwifemale-6.9402phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0~30 umol/l) and drug dose time series (for 1 hours)55688phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0~30 umol/l) drug dose time series (for 1 hours)
20body weightBN/NHsdMcwimale230.8gnaive control condition (for 21 days)55476naive control condition (for 21 days)
20body weightBN/NHsdMcwifemale147.9gnaive control condition (for 21 days)55477naive control condition (for 21 days)
20logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)BN/NHsdMcwimale-6.8698phenylephrine (0~300 umol/l) and drug dose time series (for 1.2 hours)55337phenylephrine (0~300 umol/l) drug dose time series (for 1.2 hours)
17logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)BN/NHsdMcwifemale-6.8984phenylephrine (0~300 umol/l) and drug dose time series (for 1.2 hours)55338phenylephrine (0~300 umol/l) drug dose time series (for 1.2 hours)
20body weightBN/NHsdMcwimale239.5gcontrolled sodium content diet (4 %) (for 21 days)55239controlled sodium content diet (4 %) (for 21 days)
25body weightBN/NHsdMcwifemale155.9gcontrolled sodium content diet (4 %) (for 21 days)55240controlled sodium content diet (4 %) (for 21 days)
17hypoxia-induced blood vessel dilation expressed as percent of force at maximum constrictionBN/NHsdMcwimale39.5294%phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours)55154phenylephrine (1 umol/l) controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours)controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours)
14hypoxia-induced blood vessel dilation expressed as percent of force at maximum constrictionBN/NHsdMcwifemale53.2143%phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours)55155phenylephrine (1 umol/l) controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours)controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours)
7hypoxia-induced blood vessel dilation expressed as percent of force at maximum constrictionBN/NHsdMcwimale47.4286%controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours)55095controlled sodium content diet (4 %) (for 21 days)phenylephrine (1 umol/l) controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours)controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours)
6hypoxia-induced blood vessel dilation expressed as percent of force at maximum constrictionBN/NHsdMcwifemale42.5%controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours)55096controlled sodium content diet (4 %) (for 21 days)phenylephrine (1 umol/l) controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours)controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours)
17hypoxia-induced blood vessel dilation expressed as percent of force at maximum constrictionBN/NHsdMcwimale47.1765%phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours)55066phenylephrine (1 umol/l) controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours)controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours)controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours)
14hypoxia-induced blood vessel dilation expressed as percent of force at maximum constrictionBN/NHsdMcwifemale53.3571%phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours)55067phenylephrine (1 umol/l) controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours)controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours)controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours)
20concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)BN/NHsdMcwimale0.3078umol/lcontrolled sodium content diet (4 %) (for 21 days) then phenylephrine (0~300 umol/l) and drug dose time series (for 1.2 hours)54966controlled sodium content diet (4 %) (for 21 days)phenylephrine (0~300 umol/l) drug dose time series (for 1.2 hours)
24concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)BN/NHsdMcwifemale0.1883umol/lcontrolled sodium content diet (4 %) (for 21 days) then phenylephrine (0~300 umol/l) and drug dose time series (for 1.2 hours)54967controlled sodium content diet (4 %) (for 21 days)phenylephrine (0~300 umol/l) drug dose time series (for 1.2 hours)
18acetylcholine-induced blood vessel dilation expressed as percent of force at maximum constrictionBN/NHsdMcwimale60.8333%controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0~30 umol/l) and drug dose time series (for 1 hours)54840controlled sodium content diet (4 %) (for 21 days)phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0~30 umol/l) drug dose time series (for 1 hours)
20acetylcholine-induced blood vessel dilation expressed as percent of force at maximum constrictionBN/NHsdMcwifemale66.8%controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0~30 umol/l) and drug dose time series (for 1 hours)54841controlled sodium content diet (4 %) (for 21 days)phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0~30 umol/l) drug dose time series (for 1 hours)
20concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)BN/NHsdMcwimale0.1705umol/lphenylephrine (0~300 umol/l) and drug dose time series (for 1.2 hours)54736phenylephrine (0~300 umol/l) drug dose time series (for 1.2 hours)
17concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)BN/NHsdMcwifemale0.1418umol/lphenylephrine (0~300 umol/l) and drug dose time series (for 1.2 hours)54737phenylephrine (0~300 umol/l) drug dose time series (for 1.2 hours)
19logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)BN/NHsdMcwimale-8.7773phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0~3 umol/l) and drug dose time series (for 1 hours)54631phenylephrine (1 umol/l) (for 0.2 hours)sodium nitroprusside (0~3 umol/l) drug dose time series (for 1 hours)
20logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)BN/NHsdMcwifemale-8.8084phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0~3 umol/l) and drug dose time series (for 1 hours)54632phenylephrine (1 umol/l) (for 0.2 hours)sodium nitroprusside (0~3 umol/l) drug dose time series (for 1 hours)
20logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)BN/NHsdMcwimale-8.6254controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0~3 umol/l) and drug dose time series (for 1 hours)56040controlled sodium content diet (4 %) (for 21 days)phenylephrine (1 umol/l) (for 0.2 hours)sodium nitroprusside (0~3 umol/l) drug dose time series (for 1 hours)
16logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)BN/NHsdMcwifemale-8.9211controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0~3 umol/l) and drug dose time series (for 1 hours)56041controlled sodium content diet (4 %) (for 21 days)phenylephrine (1 umol/l) (for 0.2 hours)sodium nitroprusside (0~3 umol/l) drug dose time series (for 1 hours)
20sodium nitroprusside-induced blood vessel dilation expressed as percent of force at maximum constrictionBN/NHsdMcwimale99.2%controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0~3 umol/l) and drug dose time series (for 1 hours)56327controlled sodium content diet (4 %) (for 21 days)phenylephrine (1 umol/l) (for 0.2 hours)sodium nitroprusside (0~3 umol/l) drug dose time series (for 1 hours)
16sodium nitroprusside-induced blood vessel dilation expressed as percent of force at maximum constrictionBN/NHsdMcwifemale99.1875%controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0~3 umol/l) and drug dose time series (for 1 hours)56328controlled sodium content diet (4 %) (for 21 days)phenylephrine (1 umol/l) (for 0.2 hours)sodium nitroprusside (0~3 umol/l) drug dose time series (for 1 hours)
7hypoxia-induced blood vessel dilation expressed as percent of force at maximum constrictionBN/NHsdMcwimale59%controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours)56295controlled sodium content diet (4 %) (for 21 days)phenylephrine (1 umol/l) controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours)controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours)controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours)
6hypoxia-induced blood vessel dilation expressed as percent of force at maximum constrictionBN/NHsdMcwifemale54.5%controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours)56296controlled sodium content diet (4 %) (for 21 days)phenylephrine (1 umol/l) controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours)controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours)controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours)
20concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)BN/NHsdMcwimale0.036210E-7mol/lcontrolled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0~3 umol/l) and drug dose time series (for 1 hours)56252controlled sodium content diet (4 %) (for 21 days)phenylephrine (1 umol/l) (for 0.2 hours)sodium nitroprusside (0~3 umol/l) drug dose time series (for 1 hours)
16concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)BN/NHsdMcwifemale0.015610E-7mol/lcontrolled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0~3 umol/l) and drug dose time series (for 1 hours)56253controlled sodium content diet (4 %) (for 21 days)phenylephrine (1 umol/l) (for 0.2 hours)sodium nitroprusside (0~3 umol/l) drug dose time series (for 1 hours)
20logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)BN/NHsdMcwimale-6.802controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0~300 umol/l) and drug dose time series (for 1.2 hours)56165controlled sodium content diet (4 %) (for 21 days)phenylephrine (0~300 umol/l) drug dose time series (for 1.2 hours)
24logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)BN/NHsdMcwifemale-6.9707controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0~300 umol/l) and drug dose time series (for 1.2 hours)56166controlled sodium content diet (4 %) (for 21 days)phenylephrine (0~300 umol/l) drug dose time series (for 1.2 hours)
44serum glucose levelBN/NHsdMcwimale132.7955mg/dlcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)62515controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
26serum glucose levelBN/NHsdMcwifemale145mg/dlcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)62516controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
44serum total cholesterol levelBN/NHsdMcwimale59.5227mg/dlcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)62423controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
27serum total cholesterol levelBN/NHsdMcwifemale54.2593mg/dlcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)62424controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
44serum chloride levelBN/NHsdMcwimale103.8182mmol/lcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)62351controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
27serum chloride levelBN/NHsdMcwifemale105.037mmol/lcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)62352controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
43blood eosinophil countBN/NHsdMcwimale0.1177x 1000 cells/ulcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)62269controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
27blood eosinophil countBN/NHsdMcwifemale0.1004x 1000 cells/ulcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)62270controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
44total serum bilirubin levelBN/NHsdMcwimale0.0977mg/dlcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)62187controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
27total serum bilirubin levelBN/NHsdMcwifemale0.1111mg/dlcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)62188controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
43blood lymphocyte countBN/NHsdMcwimale5.0502x 1000 cells/ulcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)62115controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
27blood lymphocyte countBN/NHsdMcwifemale5.943x 1000 cells/ulcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)62116controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
41serum aspartate aminotransferase activity levelBN/NHsdMcwimale190.4146U/lcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)62033controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
26serum aspartate aminotransferase activity levelBN/NHsdMcwifemale167.7692U/lcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)62034controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
44serum albumin levelBN/NHsdMcwimale3.8932g/dlcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)61961controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
27serum albumin levelBN/NHsdMcwifemale3.5963g/dlcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)61962controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
44serum sodium levelBN/NHsdMcwimale141.2727mmol/lcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)61839controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
27serum sodium levelBN/NHsdMcwifemale140.8148mmol/lcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)61840controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
43blood monocyte countBN/NHsdMcwimale0.1281x 1000 cells/ulcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)61737controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
27blood monocyte countBN/NHsdMcwifemale0.1348x 1000 cells/ulcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)61738controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
44serum bicarbonate levelBN/NHsdMcwimale19.2273mmol/lcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)61665controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
27serum bicarbonate levelBN/NHsdMcwifemale19.1481mmol/lcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)61666controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
44serum phosphate levelBN/NHsdMcwimale7.6091mg/dlcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)61593controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
27serum phosphate levelBN/NHsdMcwifemale7.4519mg/dlcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)61594controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
41serum alanine aminotransferase activity levelBN/NHsdMcwimale51.8293U/lcontrolled sodium content diet (4 %) then fasting (for 16 hours)61501controlled sodium content diet (4 %) fasting (for 16 hours)
26serum alanine aminotransferase activity levelBN/NHsdMcwifemale37.4615U/lcontrolled sodium content diet (4 %) then fasting (for 16 hours)61502controlled sodium content diet (4 %) fasting (for 16 hours)
43total white blood cell countBN/NHsdMcwimale7.0698x 1000 cells/ulcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)61429controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
27total white blood cell countBN/NHsdMcwifemale7.4926x 1000 cells/ulcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)61430controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
43serum potassium levelBN/NHsdMcwimale4.8mmol/lcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)61357controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
27serum potassium levelBN/NHsdMcwifemale4.1815mmol/lcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)61358controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
44serum total protein levelBN/NHsdMcwimale5.8205g/dlcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)61285controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
27serum total protein levelBN/NHsdMcwifemale5.1481g/dlcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)61286controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
43mean corpuscular hemoglobin concentrationBN/NHsdMcwimale33.507g/dlcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)61203controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
27mean corpuscular hemoglobin concentrationBN/NHsdMcwifemale32.9778g/dlcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)61204controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
44plasma anion gapBN/NHsdMcwimale23.1591mmol/lcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)61131controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
27plasma anion gapBN/NHsdMcwifemale20.9259mmol/lcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)61132controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
27plasma creatinine levelBN/NHsdMcwifemale0.2889mg/dlcontrolled sodium content diet (4 %) (for 14 days) then fasting (between 16 and 1 hours)61060controlled sodium content diet (4 %) (for 14 days)fasting (between 16 and 1 hours)
44plasma creatinine levelBN/NHsdMcwimale0.3136mg/dlcontrolled sodium content diet (4 %) (for 14 days) then fasting (between 16 and 1 hours)61059controlled sodium content diet (4 %) (for 14 days)fasting (between 16 and 1 hours)
44serum globulin levelBN/NHsdMcwimale1.9273g/dlcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)60977controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
27serum globulin levelBN/NHsdMcwifemale1.5519g/dlcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)60978controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
43blood neutrophil countBN/NHsdMcwimale1.7765x 1000 cells/ulcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)60895controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
27blood neutrophil countBN/NHsdMcwifemale1.3152x 1000 cells/ulcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)60896controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
43mean corpuscular volumeBN/NHsdMcwimale53.3558flcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)60803controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
27mean corpuscular volumeBN/NHsdMcwifemale53.863flcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)60804controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
43hematocritBN/NHsdMcwimale44.3791%controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)60691controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
27hematocritBN/NHsdMcwifemale43.7037%controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)60692controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
43red blood cell countBN/NHsdMcwimale8.3265x 10E6 cells/ulcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)60609controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
27red blood cell countBN/NHsdMcwifemale8.1185x 10E6 cells/ulcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)60610controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
43mean corpuscular hemoglobin levelBN/NHsdMcwimale17.8651pgcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)60527controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
27mean corpuscular hemoglobin levelBN/NHsdMcwifemale17.763pgcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)60528controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
44serum alkaline phosphatase activity levelBN/NHsdMcwimale60.1136U/lcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)60455controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
27serum alkaline phosphatase activity levelBN/NHsdMcwifemale43.7037U/lcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)60456controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
43blood hemoglobin levelBN/NHsdMcwimale14.8651g/dlcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)60363controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
27blood hemoglobin levelBN/NHsdMcwifemale14.4g/dlcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)60364controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
44serum calcium levelBN/NHsdMcwimale10.2705mg/dlcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)60281controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
27serum calcium levelBN/NHsdMcwifemale9.9741mg/dlcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)60282controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
44serum urea nitrogen levelBN/NHsdMcwimale25.5227mg/dlcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)60209controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
27serum urea nitrogen levelBN/NHsdMcwifemale24.5926mg/dlcontrolled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours)60210controlled sodium content diet (4 %) (for 14 days)fasting (for 16 hours)
5maximum contractile force per wet weight of aortaBN/NHsdMcwifemale2.418g/mgcontrolled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours)63192controlled sodium content diet (4 %) (for 14 days)potassium ion (80 mmol/l) (for 0.2 hours)phenylephrine (10 umol/l) (for 0.2 hours)
8maximum contractile force per wet weight of aortaBN/NHsdMcwimale2.0662g/mgcontrolled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours)63190controlled sodium content diet (4 %) (for 14 days)potassium ion (80 mmol/l) (for 0.2 hours)phenylephrine (10 umol/l) (for 0.2 hours)
8logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)BN/NHsdMcwimale-7.9575controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0~300 umol/l) and drug dose time series (for 1.2 hours)63121controlled sodium content diet (4 %) (for 14 days)phenylephrine (0~300 umol/l) drug dose time series (for 1.2 hours)
5logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)BN/NHsdMcwifemale-8.135controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0~300 umol/l) and drug dose time series (for 1.2 hours)63123controlled sodium content diet (4 %) (for 14 days)phenylephrine (0~300 umol/l) drug dose time series (for 1.2 hours)
8concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)BN/NHsdMcwimale1.2349E-7molecontrolled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0~30 umol/l) and drug dose time series (for 1 hours)63051controlled sodium content diet (4 %) (for 14 days)phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0~30 umol/l) drug dose time series (for 1 hours)
5concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)BN/NHsdMcwifemale2.006E-7molecontrolled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0~30 umol/l) and drug dose time series (for 1 hours)63053controlled sodium content diet (4 %) (for 14 days)phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0~30 umol/l) drug dose time series (for 1 hours)
8body weightBN/NHsdMcwimale226.5gcontrolled sodium content diet (4 %) (for 14 days)62964controlled sodium content diet (4 %) (for 14 days)
5body weightBN/NHsdMcwifemale148.8gcontrolled sodium content diet (4 %) (for 14 days)62966controlled sodium content diet (4 %) (for 14 days)
8logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)BN/NHsdMcwimale-6.9846controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0~30 umol/l) and drug dose time series (for 1 hours)62874controlled sodium content diet (4 %) (for 14 days)phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0~30 umol/l) drug dose time series (for 1 hours)
5logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)BN/NHsdMcwifemale-6.7078controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0~30 umol/l) and drug dose time series (for 1 hours)62876controlled sodium content diet (4 %) (for 14 days)phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0~30 umol/l) drug dose time series (for 1 hours)
8concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)BN/NHsdMcwimale0.0123umol/lcontrolled sodium content diet (4 %) (for 14 days) then phenylephrine (0~300 umol/l) and drug dose time series (for 1.2 hours)62798controlled sodium content diet (4 %) (for 14 days)phenylephrine (0~300 umol/l) drug dose time series (for 1.2 hours)
5concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)BN/NHsdMcwifemale0.0074umol/lcontrolled sodium content diet (4 %) (for 14 days) then phenylephrine (0~300 umol/l) and drug dose time series (for 1.2 hours)62800controlled sodium content diet (4 %) (for 14 days)phenylephrine (0~300 umol/l) drug dose time series (for 1.2 hours)
8acetylcholine-induced blood vessel dilation expressed as percent of force at maximum constrictionBN/NHsdMcwimale66.75%controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0~30 umol/l) and drug dose time series (for 1 hours)62651controlled sodium content diet (4 %) (for 14 days)phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0~30 umol/l) drug dose time series (for 1 hours)
5acetylcholine-induced blood vessel dilation expressed as percent of force at maximum constrictionBN/NHsdMcwifemale53.2%controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0~30 umol/l) and drug dose time series (for 1 hours)62653controlled sodium content diet (4 %) (for 14 days)phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0~30 umol/l) drug dose time series (for 1 hours)