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GENE - TERM ANNOTATION REPORT

CRRD ID: 10054143
Species: Homo sapiens
CRRD Object: Gene
Symbol: OPN1MW3
Name: opsin 1, medium wave sensitive 3
Acc ID: GO:0007186
Term: G protein-coupled receptor signaling pathway
Definition: A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
Definition Source(s): GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IBAPANTHER:PTN000662115, UniProtKB:P08100, ZFIN:ZDB-GENE-070111-2, ZFIN:ZDB-GENE-080415-3, ZFIN:ZDB-GENE-110622-12290271GO_Central (PMID:21873635)

PMID:21873635
 TAS 2290271Reactome Reactome:R-HSA-388396
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.