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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 11250
Species: Mus musculus
CRRD Object: Gene
Symbol: Rxra
Name: retinoid X receptor alpha
Acc ID: CHEBI:9753
Term: troglitazone
Definition: A chromane that has formula C24H27NO5S.
Chemical ID: MESH:C057693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDtroglitazone results in decreased expression of RXRA mRNA

PMID:28973697
increases expressionEXP 6480464CTDtroglitazone results in increased expression of RXRA mRNA

PMID:24559133
decreases response to substanceISORGD:7369296480464CTDRXRA protein results in decreased susceptibility to troglitazone

PMID:15581905
multiple interactionsISORGD:7369296480464CTDNCOA1 protein inhibits the reaction [RXRA protein results in decreased susceptibility to troglitazone], RXRA protein inhibits the reaction [BRD8 protein results in increased susceptibility to troglitazone], RXRA protein inhibits the reaction [CREBBP protein results in increased susceptibility to troglitazone], RXRA protein inhibits the reaction [NCOA1 protein results in increased susceptibility to troglitazone], troglitazone promotes the reaction [PPARG protein results in increased activity of [PPARG protein binds to RXRA protein]], troglitazone results in increased activity of [PPARG protein binds to RXRA protein], ZNF366 protein promotes the reaction [troglitazone results in increased activity of [PPARG protein binds to RXRA protein]]

PMID:15581905, PMID:20008677
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.