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CRRD ID: 11250
Species: Mus musculus
CRRD Object: Gene
Symbol: Rxra
Name: retinoid X receptor alpha
Acc ID: DOID:9074
Term: systemic lupus erythematosus
Definition: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Definition Source(s): MESH:D008180,
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IEA 13592920MouseDOOMIM:152700 , OMIM:300809 , OMIM:601744 , OMIM:605218 , OMIM:605480 , OMIM:608437 , OMIM:609903 , OMIM:609939 , OMIM:610065 , OMIM:610066 , OMIM:610927 , OMIM:612251 , OMIM:612253 , OMIM:612254 , OMIM:612378 , OMIM:613145 , OMIM:614420

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