CRRD ID: 11834437
Species: Pan paniscus
CRRD Object: Gene
Symbol: PTEN
Name: phosphatase and tensin homolog
Acc ID: DOID:4450
Term: renal cell carcinoma
Definition: A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.
Definition Source(s): MESH:D002292,,
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISSCRRD:691199068941CTDCTD Direct Evidence: marker/mechanism

 ISSCRRD:691199068941ClinVarClinVar Annotator: match by term: Renal cell carcinoma

PMID:10866302, PMID:11504908, PMID:11875759, PMID:16773562, PMID:17526801, PMID:17942903, PMID:18767981, PMID:19457929, PMID:20085938, PMID:20300775, PMID:21659347, PMID:21822720, PMID:21828076, PMID:22266152, PMID:22320991, PMID:22327138, PMID:22595938, PMID:23335809, PMID:23399955, PMID:23470840, PMID:24778394, PMID:25157968, PMID:25527629, PMID:26619011, PMID:26798346, PMID:27477328, PMID:28492532, PMID:9467011, PMID:9915974
 ISSCRRD:691199068941ClinVarClinVar Annotator: match by term: Renal cell carcinoma

PMID:11504908, PMID:18767981, PMID:20085938, PMID:21824802, PMID:25157968, PMID:26619011
 ISSCRRD:691199068941ClinVarClinVar Annotator: match by term: Renal cell carcinoma

PMID:21659347, PMID:23335809, PMID:24778394, PMID:25527629, PMID:25741868, PMID:26619011, PMID:9467011
 ISSCRRD:691199068941ClinVarClinVar Annotator: match by term: Renal cell carcinoma

PMID:21828076, PMID:22266152, PMID:26619011, PMID:28492532, PMID:9467011
 ISSCRRD:691199068941CRRD PMID:17681738, REF_RGD_ID:1643331
 ISSCRRD:691199068941CRRDprotein:decreased expression:kidney

PMID:17886097, REF_RGD_ID:2292500
 ISSCRRD:691199068941CRRDprotein:decreased expression:kidney (rat)

PMID:22737271, REF_RGD_ID:12802360
disease_progressionISSCRRD:691199068941CRRD PMID:15821467, REF_RGD_ID:2292513
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.