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GENE - TERM ANNOTATION REPORT

CRRD ID: 11838730
Species: Pan paniscus
CRRD Object: Gene
Symbol: CHRNA2
Name: cholinergic receptor nicotinic alpha 2 subunit
Acc ID: DOID:1826
Term: epilepsy
Definition: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
Definition Source(s): MESH:D004827, http://books.google.com/books?id=YXqX04Te9ioC&printsec=frontcover&source=gbs_ge_summary_r&cad=0#v=onepage&q&f=false, http://www.merriam-webster.com/medlineplus/epilepsy
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CHRNA2 ISORGD:100524549068941ClinVarClinVar Annotator: match by term: Seizures

PMID:26467025, PMID:28492532
CHRNA2 ISORGD:103956389068941ClinVarClinVar Annotator: match by term: Seizures

PMID:28492532
CHRNA2 ISORGD:103956529068941ClinVarClinVar Annotator: match by term: Seizures

PMID:28492532
CHRNA2 ISORGD:103956559068941ClinVarClinVar Annotator: match by term: Seizures

PMID:28492532
CHRNA2 ISORGD:103956569068941ClinVarClinVar Annotator: match by term: Seizures

 
CHRNA2 ISORGD:103956579068941ClinVarClinVar Annotator: match by term: Seizures

PMID:28492532
CHRNA2 ISORGD:116072469068941ClinVarClinVar Annotator: match by term: Seizures

PMID:26467025, PMID:28492532
CHRNA2 ISORGD:116081019068941ClinVarClinVar Annotator: match by term: Seizures

PMID:28492532
CHRNA2 ISORGD:127916939068941ClinVarClinVar Annotator: match by term: Seizures

 
CHRNA2 ISORGD:128363779068941ClinVarClinVar Annotator: match by term: Seizures

PMID:28492532
CHRNA2 ISORGD:128372989068941ClinVarClinVar Annotator: match by term: Seizures

PMID:28492532
CHRNA2 ISORGD:128404219068941ClinVarClinVar Annotator: match by term: Seizures

PMID:28492532
CHRNA2 ISORGD:129007549068941ClinVarClinVar Annotator: match by term: Seizures

 
CHRNA2 ISORGD:129057879068941ClinVarClinVar Annotator: match by term: Seizures

 
CHRNA2 ISORGD:138284799068941ClinVarClinVar Annotator: match by term: Seizures

 
CHRNA2 ISORGD:138291149068941ClinVarClinVar Annotator: match by term: Seizures

 
CHRNA2 ISORGD:138298289068941ClinVarClinVar Annotator: match by term: Seizures

 
CHRNA2 ISORGD:138304049068941ClinVarClinVar Annotator: match by term: Seizures

 
CHRNA2 ISORGD:138304509068941ClinVarClinVar Annotator: match by term: Seizures

 
CHRNA2 ISORGD:138306809068941ClinVarClinVar Annotator: match by term: Seizures

 
CHRNA2 ISORGD:86592749068941ClinVarClinVar Annotator: match by term: Seizures

PMID:28492532
CHRNA2 ISORGD:86592759068941ClinVarClinVar Annotator: match by term: Seizures

 
CHRNA2 ISORGD:86592769068941ClinVarClinVar Annotator: match by term: Seizures

 
CHRNA2 ISORGD:86592779068941ClinVarClinVar Annotator: match by term: Seizures

 
CHRNA2 ISORGD:86592789068941ClinVarClinVar Annotator: match by term: Seizures

PMID:28492532
CHRNA2 ISORGD:86592799068941ClinVarClinVar Annotator: match by term: Seizures

PMID:28492532
CHRNA2 ISORGD:86905029068941ClinVarClinVar Annotator: match by term: Seizures

PMID:28492532
CHRNA2 ISORGD:86905059068941ClinVarClinVar Annotator: match by term: Seizures

PMID:24950454, PMID:25741868, PMID:26467025, PMID:28492532
CHRNA2 ISORGD:96928099068941ClinVarClinVar Annotator: match by term: Seizures

PMID:28492532
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.