CRRD ID: 11929106
Species: Pan paniscus
CRRD Object: Gene
Symbol: LEP
Name: leptin
Acc ID: DOID:9452
Term: fatty liver disease
Definition: Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.
Definition Source(s): MESH:D005234,
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISSCRRD:691239068941CTDCTD Direct Evidence: marker/mechanism

PMID:12661780, PMID:23839791, PMID:24525044, PMID:25554529, PMID:27712037
 ISSCRRD:691239068941CRRDassociated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma

PMID:18713300, REF_RGD_ID:2311137
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.