GENE - TERM ANNOTATION REPORT

CRRD ID: 11929106
Species: Pan paniscus
CRRD Object: Gene
Symbol: LEP
Name: leptin
Acc ID: DOID:9452
Term: fatty liver disease
Definition: Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.
Definition Source(s): MESH:D005234, http://en.wikipedia.org/wiki/Fatty_liver
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISSCRRD:691239068941CTDCTD Direct Evidence: marker/mechanism

PMID:12661780, PMID:23839791, PMID:24525044, PMID:25554529, PMID:27712037
 ISSCRRD:691239068941CRRDassociated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma

PMID:18713300, REF_RGD_ID:2311137
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.