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GENE - TERM ANNOTATION REPORT

CRRD ID: 11954907
Species: Pan paniscus
CRRD Object: Gene
Symbol: ERN1
Name: endoplasmic reticulum to nucleus signaling 1
Acc ID: GO:0036498
Term: IRE1-mediated unfolded protein response
Definition: A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB.
Definition Source(s): GOC:bf, GOC:PARL, PMID:22013210
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ERN1 ISSRGD:16051259068941GO_Central PMID:21873635
ERN1 ISSRGD:16051259068941Reactome Reactome:R-HSA-381070
ERN1 ISSRGD:16051259068941WormBase PMID:11779465, PMID:19328063, PMID:29198525, PMID:9637683
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.