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CRRD ID: 12099025
Species: Canis lupus familiaris
CRRD Object: Gene
Symbol: ADCY5
Name: adenylate cyclase 5
Acc ID: DOID:14330
Term: Parkinson's disease
Definition: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
Definition Source(s): MESH:D010300,
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISSRGD:117612139068941MouseDOOMIM:168600 , OMIM:300557 , OMIM:556500 , OMIM:602404 , OMIM:606852 , OMIM:607688 , OMIM:610297 , OMIM:613164 , OMIM:613643 , OMIM:614251

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