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GENE - TERM ANNOTATION REPORT

CRRD ID: 12224708
Species: Canis lupus familiaris
CRRD Object: Gene
Symbol: IGFBP3
Name: insulin like growth factor binding protein 3
Acc ID: DOID:1612
Term: breast cancer
Definition: A thoracic cancer that originates in the mammary gland. (DO)
Definition Source(s): url:http://en.wikipedia.org/wiki/Breast_cancer "DO", url:http://en.wikipedia.org/wiki/Mammary "DO", url:http://www.cancer.gov/cancertopics/types/breast "DO", url:http://www.nlm.nih.gov/medlineplus/breastcancer.html "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IGFBP3 ISORGD:7360429068941CRRDDNA:SNP:promoter, CDS:variant allele of multiple SNPs including rs2854744, associated with increased risk singly and in combination, 1, 193 patients and 1, 310 control Chinese women in Shanghai

PMID:15298948, REF_RGD_ID:2290011
IGFBP3 ISORGD:7360429068941CRRDprotein:decreased expression:serum

PMID:10069662, PMID:17287408, REF_RGD_ID:2301715, REF_RGD_ID:2301716
IGFBP3no_associationISORGD:7360429068941CRRDDNA:SNP:promoter:no association with rs2854744, 677 cases and 834 controls from the Nurses' Health Study

PMID:12925957, REF_RGD_ID:2290009
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.