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CRRD ID: 12434129
Species: Canis lupus familiaris
CRRD Object: Gene
Symbol: RUVBL1
Name: RuvB like AAA ATPase 1
Acc ID: GO:0035267
Term: NuA4 histone acetyltransferase complex
Definition: A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).
Definition Source(s): GOC:ecd, PMID:10966108, PMID:14966270
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RUVBL1 IBAFB:FBgn0040075, FB:FBgn0040078, PANTHER:PTN000120244, UniProtKB:Q9Y230, UniProtKB:Q9Y26513508589GO_Central (PMID:21873635)

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.