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CRRD ID: 12434129
Species: Canis lupus familiaris
CRRD Object: Gene
Symbol: RUVBL1
Name: RuvB like AAA ATPase 1
Acc ID: GO:0097255
Term: R2TP complex
Definition: A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others.
Definition Source(s): GOC:mcc, PMID:15766533, PMID:21925213
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RUVBL1 IBAPANTHER:PTN000120244, SGD:S000002598, SGD:S000006156, UniProtKB:Q9Y230, UniProtKB:Q9Y26513508589GO_Central (PMID:21873635)

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.