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GENE - TERM ANNOTATION REPORT

CRRD ID: 12539558
Species: Ictidomys tridecemlineatus
CRRD Object: Gene
Symbol: Mbd3
Name: methyl-CpG binding domain protein 3
Acc ID: GO:0016581
Term: NuRD complex
Definition: An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.
Definition Source(s): PMID:10589671, PMID:11743021, PMID:17289569
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mbd3 ISOPR:Q8K4B0, PR:Q9R190, PR:O091069068941MGI (MGI:MGI:3619832, PMID:16462733)

MGI:MGI:3619832, PMID:16462733
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.