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GENE - TERM ANNOTATION REPORT

CRRD ID: 12644435
Species: Ictidomys tridecemlineatus
CRRD Object: Gene
Symbol: Egln2
Name: egl-9 family hypoxia inducible factor 2
Acc ID: PW:0000243
Term: vascular endothelial growth factor signaling pathway
Definition: The VEGF family plays key roles in angiogenesis and lymphangiogenesis. Through their receptors, VEGFs can initiate a diverse and complex network of signaling cascades. Deregulation of VEGFs mediated pathways, mostly through upregulation of VEGFs expression, has been implicated in a number of conditions, primarily cancer.
Definition Source(s): GO:0048010, KEGG:map04370, OneLook:www.onelook.com, PMID:15544039, PMID:15563310, Reactome:REACT_12529.1
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egln2 ISORGD:6313769068941CRRD PMID:12876291, REF_RGD_ID:727754
Egln2 ISORGD:7363289068941CRRD PMID:14597660, PMID:15563310, REF_RGD_ID:1334463, REF_RGD_ID:1334466
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.