GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1302972
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ehmt2
Name: euchromatic histone lysine methyltransferase 2
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISOCRRD:15501736480464CTDEHMT2 protein promotes the reaction [Tretinoin promotes the reaction [CBX1 protein binds to POU5F1 promoter]]

EHMT2 protein promotes the reaction [Tretinoin promotes the reaction [CBX1 protein binds to ZFP42 promoter]]

EHMT2 protein promotes the reaction [Tretinoin results in increased methylation of POU5F1 promoter]

PMID:16415856
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.