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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1303274
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Dnmt3b
Name: DNA methyltransferase 3 beta
Acc ID: CHEBI:28088
Term: genistein
Definition: 7-Hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISOCRRD:16060376480464CTDGenistein results in decreased expression of DNMT3B mRNA

Genistein results in decreased expression of DNMT3B protein

PMID:19221000, PMID:23593078
multiple interactionsISOCRRD:16060376480464CTDGenistein promotes the reaction [DNMT3B protein binds to COMT promoter]

PMID:30684530
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.