GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1305069
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Smad6
Name: SMAD family member 6
Acc ID: CHEBI:78420
Term: icariin
Definition: A member of the class of flavonols that is kaempferol which is substituted at position 8 by a 3-methylbut-2-en-1-yl group and in which the hydroxy groups at positions 3, 4', and 7 have been converted to the corresponding 6-deoxy-alpha-L-mannopyranoside, methyl ether, and beta-D-glucopyranoside, respectively. A phoshphodiesterase-5 inhibitor, it is obtained from several species of plants in the genus Epimedium and is thought to be the main active ingredient of the Chinese herbal medicine Herba Epimedii (yinyanghuo).
Chemical ID: MESH:C056599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISOCRRD:13128816480464CTDSMAD6 protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA]

SMAD6 protein inhibits the reaction [icariin results in increased expression of SPP1 mRNA]

PMID:18295595
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.