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CRRD ID: 1305528
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Fbxl12
Name: F-box and leucine-rich repeat protein 12
Acc ID: GO:0031146
Term: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Definition: The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.
Definition Source(s): PMID:15380083
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IBAMGI:MGI:1354702, PANTHER:PTN001923412, PomBase:SPCC338.16, SGD:S000005606, UniProtKB:Q9UKT713792537GO_CentralPMID:21873635

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.