Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1306113
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Fjx1
Name: four-jointed box kinase 1
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:13145376480464CTDValproic Acid affects the expression of FJX1 mRNA

PMID:25979313
decreases expressionISORGD:13145376480464CTDValproic Acid results in decreased expression of FJX1 mRNA

PMID:23179753, PMID:24383497, PMID:26272509
decreases methylationISORGD:13145376480464CTDValproic Acid results in decreased methylation of FJX1 gene

PMID:29154799
increases expressionISORGD:13145376480464CTDValproic Acid results in increased expression of FJX1 mRNA

PMID:23179753, PMID:27188386
multiple interactionsISORGD:13145376480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FJX1 mRNA

PMID:27188386
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.