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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1306167
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Stub1
Name: STIP1 homology and U-box containing protein 1
Acc ID: CHEBI:5292
Term: geldanamycin
Definition: An ansamycin consisting of a 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria.
Chemical ID: MESH:C001277
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:13146296480464CTDgeldanamycin inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]], geldanamycin promotes the reaction [ESR1 protein binds to STUB1 protein], STUB1 protein promotes the reaction [geldanamycin results in increased degradation of ESR1 protein]

PMID:16037132, PMID:25645596
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.