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GENE - TERM ANNOTATION REPORT

CRRD ID: 1306167
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Stub1
Name: STIP1 homology and U-box containing protein 1
Acc ID: GO:0061630
Term: ubiquitin protein ligase activity
Definition: Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
Definition Source(s): GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.