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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1306661
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Chuk
Name: component of inhibitor of nuclear factor kappa B kinase complex
Acc ID: CHEBI:36706
Term: resiquimod
Definition: An imidazoquinoline that has formula C17H22N4O2.
Chemical ID: MESH:C402365
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISOCRRD:13154016480464CTD2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide inhibits the reaction [resiquimod results in increased phosphorylation of and results in increased degradation of CHUK protein]

5-7-oxo-zeaenol inhibits the reaction [resiquimod results in increased phosphorylation of and results in increased degradation of CHUK protein]

PMID:28924041
multiple interactionsISOCRRD:13154026480464CTDresiquimod results in increased phosphorylation of and results in increased degradation of CHUK protein

PMID:28924041
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.