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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1307751
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Srebf2
Name: sterol regulatory element binding transcription factor 2
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDSimvastatin results in increased expression of SREBF2 mRNA

PMID:12056585
multiple interactionsEXP 6480464CTDMevalonic Acid inhibits the reaction [Simvastatin results in increased expression of SREBF2 mRNA]

Simvastatin results in increased activity of and results in increased localization of SREBF2 protein

PMID:12056585
increases expressionISOCRRD:7309726480464CTDSimvastatin results in increased expression of SREBF2 protein modified form

PMID:20018177
multiple interactionsISOCRRD:7309726480464CTDMevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]]

Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]

PMID:14500290
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.