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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1308692
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nfatc3
Name: nuclear factor of activated T-cells 3
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted to the corresponding acetate and myristate esters.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISOCRRD:13186136480464CTDNFATC3 protein promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNFSF10 protein]

PMID:21603612
multiple interactionsISOCRRD:16151766480464CTD[[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]] which results in increased expression of IL4 mRNA

[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]

bisphenol A promotes the reaction [[[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]] which results in increased expression of IL4 mRNA]

nonylphenol promotes the reaction [[[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]] which results in increased expression of IL4 mRNA]

PMID:12709020
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.