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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1308846
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Irak3
Name: interleukin-1 receptor-associated kinase 3
Acc ID: CHEBI:30853
Term: glycyrrhetinic acid
Definition: A pentacyclic triterpenoid that is olean-12-ene substituted by a hydroxy group at position 3, an oxo group at position 11 and a carboxy group at position 30.
Chemical ID: MESH:C119129
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13188546480464CTDGlycyrrhetinic Acid results in increased expression of IRAK3 protein

PMID:28213090
multiple interactionsISORGD:13188546480464CTD[Glycyrrhetinic Acid co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IRAK3 mRNA, IRAK3 protein promotes the reaction [Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]]

PMID:28213090
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.