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GENE - TERM ANNOTATION REPORT

CRRD ID: 1309875
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Lig3
Name: DNA ligase 3
Acc ID: GO:0097681
Term: double-strand break repair via alternative nonhomologous end joining
Definition: An instance of double-strand break repair via nonhomologous end joining that is independent of factors important for V(D)J recombination (as opposed to classical nonhomologous end joining). It often results in a deletion with microhomology (i.e. 5-25bp homology) at the repair junction. Among different subclasses of nonhomologous end joining (NHEJ), alternative NHEJ appears to play a significant role in the etiology of mutations that arise during cancer development and treatment.
Definition Source(s): GOC:rph, http://en.wikipedia.org/wiki/Microhomology-mediated_end_joining, PMID:18584027, PMID:21655080
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.