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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1310533
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Crbn
Name: cereblon
Acc ID: CHEBI:63791
Term: lenalidomide
Definition: A dicarboximide that consists of 1-oxoisoindoline bearing an amino substituent at position 4 and a 2,6-dioxopiperidin-3-yl group at position 2. Inhibits the secretion of TNF-alpha.
Chemical ID: MESH:C467567
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingISOCRRD:13214926480464CTDlenalidomide binds to [CRBN protein binds to DDB1 protein]

lenalidomide binds to [SALL4 protein binds to CRBN protein]

PMID:25108355, PMID:30067223
increases response to substanceISOCRRD:13214926480464CTDCRBN results in increased susceptibility to lenalidomide

PMID:26186254
multiple interactionsISOCRRD:13214926480464CTDlenalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein]

PMID:25043012
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.