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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1313365
Species: Homo sapiens
CRRD Object: Gene
Symbol: GALK1
Name: galactokinase 1
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GALK1 mRNA

PMID:19710929
increases expressionISORGD:106176480464CTDpirinixic acid results in increased expression of GALK1 mRNA

PMID:17426115, PMID:18301758, PMID:20059764, PMID:23811191
multiple interactionsISORGD:106176480464CTD[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GALK1 mRNA, PPARA protein promotes the reaction [pirinixic acid results in increased expression of GALK1 mRNA]

PMID:19710929, PMID:20059764
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.