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GENE - TERM ANNOTATION REPORT

CRRD ID: 1317982
Species: Homo sapiens
CRRD Object: Gene
Symbol: NUDT15
Name: nudix hydrolase 15
Acc ID: DOID:9002041
Term: Poor Metabolism of Thiopurines, 2
Definition: A severe hematopoietic toxicity upon treatment of patients with standard doses of thiopurines, a class of antineoplastic/immunosuppressant agents that consists of mercaptopurine, thioguanine, and azathioprine. (OMIM)
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IAGP 7240710OMIM  
 IAGPRGD:110751258554872ClinVarClinVar Annotator: match by term: Thiopurines, poor metabolism of, 2

PMID:26878724
 IAGPRGD:110751378554872ClinVarClinVar Annotator: match by term: Thiopurines, poor metabolism of, 2

PMID:26878724
 IAGPRGD:110751388554872ClinVarClinVar Annotator: match by term: Thiopurines, poor metabolism of, 2

PMID:22992668, PMID:25108385, PMID:25624441, PMID:26033531, PMID:26076924, PMID:26405151, PMID:26503813, PMID:26590936, PMID:26735160, PMID:26878724, PMID:27095468, PMID:27193222, PMID:27381176, PMID:27416873, PMID:27530327, PMID:27558924, PMID:27577869, PMID:27604507, PMID:28088792, PMID:28146264
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.