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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1319092
Species: Homo sapiens
CRRD Object: Gene
Symbol: NTS
Name: neurotensin
Acc ID: CHEBI:15738
Term: staurosporine
Definition: An indolocarbazole alkaloid that has formula C28H26N4O3.
Chemical ID: MESH:D019311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityEXP 6480464CTDStaurosporine results in increased activity of NTS protein

PMID:18313772
multiple interactionsEXP 6480464CTDStaurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein], Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein], Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein], Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein], Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein], Staurosporine promotes the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates], Tetradecanoylphorbol Acetate inhibits the reaction [Staurosporine results in increased activity of NTS protein]

PMID:15177934, PMID:18313772
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.