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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1319092
Species: Homo sapiens
CRRD Object: Gene
Symbol: NTS
Name: neurotensin
Acc ID: CHEBI:90690
Term: U-73122
Definition: An aza-steroid that is 3-O-methyl-17beta-estradiol in which the 17beta-hydroxy group is replaced by a 6-(maleimid-1-yl)hexylamino group. An inibitor of phospholipase C.
Chemical ID: MESH:C060229
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD1-(6-((3-methoxyestra-1, 3, 5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2, 5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein], 1-(6-((3-methoxyestra-1, 3, 5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2, 5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein], 1-(6-((3-methoxyestra-1, 3, 5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2, 5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein], 1-(6-((3-methoxyestra-1, 3, 5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2, 5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]

PMID:15177934
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.