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GENE - TERM ANNOTATION REPORT

CRRD ID: 1320761
Species: Homo sapiens
CRRD Object: Gene
Symbol: COPS7A
Name: COP9 signalosome subunit 7A
Acc ID: GO:0008180
Term: COP9 signalosome
Definition: A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
Definition Source(s): PMID:11019806, PMID:12186635, PMID:14570571
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IBAFB:FBgn0028836, PANTHER:PTN000394350, UniProtKB:Q94JU3, UniProtKB:Q9H9Q2, UniProtKB:Q9UBW8, dictyBase:DDB_G02712822290271GO_Central (PMID:21873635)

PMID:21873635
 IDA 2290271UniProtKB (PMID:18850735)

PMID:18850735
 IEAInterPro:IPR0377572290271InterPro GO_REF:0000002
 IEAInterPro:IPR037757, InterPro:IPR0414812290271InterPro GO_REF:0000002
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.