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GENE - TERM ANNOTATION REPORT

CRRD ID: 1321715
Species: Mus musculus
CRRD Object: Gene
Symbol: Flt3
Name: FMS-like tyrosine kinase 3
Acc ID: DOID:5600
Term: precursor lymphoblastic lymphoma/leukemia
Definition: A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
Definition Source(s): MESH:D054198, https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&version=14.10d&code=C7055
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISORGD:13217148554872ClinVarClinVar Annotator: match by OMIM:613065

PMID:14670924
 ISORGD:13217148554872ClinVarClinVar Annotator: match by term: Acute lymphoid leukemia

PMID:11290608, PMID:11442493, PMID:14670924, PMID:15256420, PMID:16857985, PMID:17889720, PMID:19657110, PMID:20733134, PMID:22368270, PMID:22504183, PMID:22504184, PMID:23261068, PMID:23321257, PMID:23430109, PMID:23714533, PMID:23783394, PMID:25157968
 ISORGD:13217148554872ClinVarClinVar Annotator: match by term: Acute lymphoid leukemia

PMID:11290608, PMID:14604974, PMID:14670924, PMID:15256420, PMID:16857985, PMID:17606455, PMID:19657110, PMID:20733134, PMID:22368270, PMID:22504183, PMID:22504184, PMID:23261068, PMID:23321257, PMID:23430109, PMID:23714533, PMID:23783394, PMID:24046014, PMID:25157968
 ISORGD:132171411554173CTDCTD Direct Evidence: marker/mechanism

 
susceptibilityISORGD:13217147240710OMIM  
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