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GENE - TERM ANNOTATION REPORT

CRRD ID: 1321715
Species: Mus musculus
CRRD Object: Gene
Symbol: Flt3
Name: FMS-like tyrosine kinase 3
Acc ID: DOID:9119
Term: acute myeloid leukemia
Definition: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
Definition Source(s): MESH:D015470, http://cancergenome.nih.gov/cancersselected/acutemyeloidleukemia, http://en.wikipedia.org/wiki/Acute_myeloid_leukemia, http://www.cancer.gov/dictionary?cdrid=44363, https://www.cancer.org/cancer/acute-myeloid-leukemia/detection-diagnosis-staging/how-classified.html
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IEA 13592920MouseDOOMIM:601626

 
 IMP 11049471CRRD  
 ISORGD:13217141598955CRRD  
 ISORGD:13217147240710OMIM  
 ISORGD:13217148554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemia

PMID:11290608, PMID:15256420, PMID:15374878, PMID:16857985, PMID:19657110, PMID:20733134, PMID:22368270, PMID:22504183, PMID:22504184, PMID:23261068, PMID:23321257, PMID:23430109, PMID:23714533, PMID:23783394, PMID:25157968
 ISORGD:13217148554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemia

PMID:14737077
 ISORGD:13217148554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemia

PMID:15625552
 ISORGD:13217148554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemia

PMID:15667533
 ISORGD:13217148554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemia

PMID:15863200, PMID:22368270, PMID:22504186, PMID:23261068, PMID:23321257, PMID:23714533, PMID:23783394
 ISORGD:13217148554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemia

PMID:16091740
 ISORGD:13217148554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemia

PMID:16371029
 ISORGD:13217148554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemia

PMID:16410449
 ISORGD:13217148554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemia

PMID:16573742
 ISORGD:13217148554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemia

PMID:16857985, PMID:20733134, PMID:22368270, PMID:22504183, PMID:22504184, PMID:23261068, PMID:23321257, PMID:23430109, PMID:23714533, PMID:23783394
 ISORGD:13217148554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemia

PMID:16990784
 ISORGD:13217148554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemia

PMID:19840437, PMID:22368270, PMID:22504186, PMID:23261068, PMID:23321257, PMID:23714533, PMID:23783394, PMID:25157968
 ISORGD:13217148554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemia

PMID:22504184
 ISORGD:13217148554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemia

PMID:22504184, PMID:23430109, PMID:24619500
 ISORGD:13217148554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemia

PMID:23878140, PMID:24619500
 ISORGD:13217148554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemia

PMID:25157968
 ISORGD:13217148554872ClinVarClinVar Annotator: match by term: Leukemia, acute myelogenous

PMID:11290608, PMID:11442493, PMID:14604974, PMID:15256420, PMID:16857985, PMID:17047150, PMID:20733134, PMID:22368270, PMID:22504184, PMID:23261068, PMID:23321257, PMID:23430109, PMID:23714533, PMID:23783394, PMID:24046014, PMID:25157968
 ISORGD:13217148554872ClinVarClinVar Annotator: match by term: Leukemia, acute myelogenous

PMID:11290608, PMID:11442493, PMID:14670924, PMID:15256420, PMID:16857985, PMID:17889720, PMID:19657110, PMID:20733134, PMID:22368270, PMID:22504183, PMID:22504184, PMID:23261068, PMID:23321257, PMID:23430109, PMID:23714533, PMID:23783394, PMID:25157968
 ISORGD:13217148554872ClinVarClinVar Annotator: match by term: Leukemia, acute myelogenous

PMID:11290608, PMID:14604974, PMID:14670924, PMID:15256420, PMID:16857985, PMID:17606455, PMID:19657110, PMID:20733134, PMID:22368270, PMID:22504183, PMID:22504184, PMID:23261068, PMID:23321257, PMID:23430109, PMID:23714533, PMID:23783394, PMID:24046014, PMID:25157968
 ISORGD:13217148554872ClinVarClinVar Annotator: match by term: Leukemia, acute myelogenous

PMID:11290608, PMID:15256420, PMID:16857985, PMID:20733134, PMID:22368270, PMID:22504184, PMID:22504185, PMID:23261068, PMID:23321257, PMID:23430109, PMID:23714533, PMID:23783394
 ISORGD:13217148554872ClinVarClinVar Annotator: match by term: Leukemia, acute myelogenous

PMID:11442493, PMID:25157968
 ISORGD:13217148554872ClinVarClinVar Annotator: match by term: Leukemia, acute myeloid, reduced survival in

PMID:11091200, PMID:11290608, PMID:17387224, PMID:17942876, PMID:19602710
 ISORGD:13217148554872ClinVarClinVar Annotator: match by term: Leukemia, acute myeloid, UMLS MESH term: Acute Myelogenous Leukemia

PMID:12384447
 ISORGD:132171411049466CRRDmRNA, protein:increased expression:bone marrow:

 
 ISORGD:132171411049497CRRDDNA:missense mutation:exon:p.D835Y, D835H(human)

 
 ISORGD:132171411554173CTDCTD Direct Evidence: marker/mechanism

PMID:17050201, PMID:17184839, PMID:19822134, PMID:21441929, PMID:21482694, PMID:21928377, PMID:22409268, PMID:23036488, PMID:23906301, PMID:24526162, PMID:25053825, PMID:27099147, PMID:27992414
disease_progressionISORGD:132171411049467CRRDDNA:duplication mutation:cds:

 
treatmentISORGD:132171411049482CRRDDNA:mutations:cds:

 
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.