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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1323510
Species: Mus musculus
CRRD Object: Gene
Symbol: Akr1c21
Name: aldo-keto reductase family 1, member C21
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:13539016480464CTDValproic Acid affects the expression of AKR1C2 mRNA

PMID:25979313
decreases methylationISORGD:13539016480464CTDValproic Acid results in decreased methylation of AKR1C2 gene

PMID:29154799
increases expressionISORGD:13539016480464CTDValproic Acid results in increased expression of AKR1C2 mRNA

PMID:23179753, PMID:24383497, PMID:24935251, PMID:26272509, PMID:28001369
multiple interactionsISORGD:13539016480464CTD[Hydralazine co-treated with Valproic Acid] results in increased expression of AKR1C2 mRNA, [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C2 mRNA

PMID:17183730, PMID:27188386
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.