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CRRD ID: 1332300
Species: Mus musculus
CRRD Object: Gene
Symbol: Duox2
Name: dual oxidase 2
Acc ID: GO:0042554
Term: superoxide anion generation
Definition: The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways.
Definition Source(s): GOC:jl, PMID:12359750
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IBAMGI:MGI:1354184, MGI:MGI:2450016, MGI:MGI:2681162, PANTHER:PTN000239643, RGD:620598, UniProtKB:P04839, UniProtKB:Q96PH1, UniProtKB:Q9Y5S8, dictyBase:DDB_G02871012290270GO_Central (PMID:21873635)

 ISOUniProtKB:Q9NRD82290270MGI GO_REF:0000096, MGI:MGI:4834177
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.