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GENE - TERM ANNOTATION REPORT

CRRD ID: 1332300
Species: Mus musculus
CRRD Object: Gene
Symbol: Duox2
Name: dual oxidase 2
Acc ID: GO:0043020
Term: NADPH oxidase complex
Definition: A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2.
Definition Source(s): GOC:jl, PMID:11483596, PMID:12440767
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IBAMGI:MGI:2681162, MGI:MGI:88574, PANTHER:PTN000239643, RGD:620574, RGD:620598, RGD:620600, UniProtKB:P04839, UniProtKB:Q9Y5S82290270GO_Central (PMID:21873635)

PMID:21873635
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.