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CRRD ID: 1349671
Species: Homo sapiens
CRRD Object: Gene
Symbol: TAF1
Name: TATA-box binding protein associated factor 1
Acc ID: GO:0005669
Term: transcription factor TFIID complex
Definition: A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.
Definition Source(s): GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IBAFB:FBgn0010355, PANTHER:PTN000356981, PomBase:SPAC2G11.14, SGD:S000003506, UniProtKB:P216752290271GO_Central (PMID:21873635)

 IDA 2290271MGI (PMID:14580349), (PMID:24927529), (PMID:27007846), (PMID:8625415)

PMID:14580349, PMID:24927529, PMID:27007846, PMID:8625415
 TAS 2290271ParkinsonsUK-UCL (PMID:12498690), (PMID:25412659)

PMID:12498690, PMID:25412659
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.