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GENE - TERM ANNOTATION REPORT

CRRD ID: 1352437
Species: Homo sapiens
CRRD Object: Gene
Symbol: BRK1
Name: BRICK1 subunit of SCAR/WAVE actin nucleating complex
Acc ID: GO:0031209
Term: SCAR complex
Definition: A pentameric complex that includes orthologues of human PIR121, Nap1, Abi, SCAR, and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction.
Definition Source(s): GOC:hla, GOC:pg, PMID:12181570, PMID:24036345, PMID:24630101
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IBAFB:FBgn0061198, PANTHER:PTN002133680, UniProtKB:Q8WUW1, dictyBase:DDB_G02791752290271GO_Central (PMID:21873635)

PMID:21873635
 IDA 2290271UniProt (PMID:18560548), (PMID:21107423)

PMID:18560548, PMID:21107423
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.