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GENE - TERM ANNOTATION REPORT

CRRD ID: 13975366
Species: Sus scrofa
CRRD Object: Gene
Symbol: DSC3
Name: desmocollin 3
Acc ID: GO:0030057
Term: desmosome
Definition: A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism.
Definition Source(s): GOC:mah, GOC:mtg_muscle, ISBN:0815332181
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DSC3 IBAMGI:MGI:103221, MGI:MGI:109173, MGI:MGI:1194993, PANTHER:PTN002771418, UniProtKB:Q0248714298760GO_Central (PMID:21873635)

PMID:21873635
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.