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GENE - TERM ANNOTATION REPORT

CRRD ID: 13997491
Species: Sus scrofa
CRRD Object: Gene
Symbol: FOXO3
Name: forkhead box O3
Acc ID: DOID:7148
Term: rheumatoid arthritis
Definition: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
Definition Source(s): MESH:D001172, url:http://en.wikipedia.org/wiki/Rheumatoid_arthritis "DO", url:http://www.arthritis.org/disease-center.php?disease_id=31 "DO", url:http://www.mayoclinic.org/diseases-conditions/rheumatoid-arthritis/home/ovc-20197388 "DO", url:http://www.medicinenet.com/rheumatoid_arthritis/article.htm "DO", url:http://www.nlm.nih.gov/medlineplus/ency/article/000431.htm "DO", url:http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=rheumatoid%20arthritis "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FOXO3 ISORGD:13194039068941CRRDmRNA, protein:increased expression:peripheral blood mononuclear cell, polymorphonuclear cell, synovium:

PMID:19435720, REF_RGD_ID:10402186
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.