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GENE - TERM ANNOTATION REPORT

CRRD ID: 14245075
Species: Sus scrofa
CRRD Object: Gene
Symbol: PRMT6
Name: protein arginine methyltransferase 6
Acc ID: PW:0000048
Term: methionine cycle/metabolic pathway
Definition: Those metabolic reactions involved in the synthesis (remethylation), utilization and/or degradation of methionine, an essential amino acid for humans. The cycle produces S-adenosylmethionine (AdoMet), the major methyl donor for proteins, nucleic acids, lipids and other small molecules. The cycle also produces homocysteine (Hcy) which either regenerates methionine via the remethylation pathway or leads to the synthesis of cysteine and derivatives via the transsulfuration pathway. Homocysteine and folate metabolic pathways are intimately related to the methionine cycle.
Definition Source(s): MCW library book:Homocysteine in Health and Disease
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PRMT6 ISORGD:13122999068941CRRD PMID:15866169, PMID:21074527, REF_RGD_ID:1359044, REF_RGD_ID:7242552
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.