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GENE - TERM ANNOTATION REPORT

CRRD ID: 14268113
Species: Sus scrofa
CRRD Object: Gene
Symbol: CHRNA4
Name: cholinergic receptor nicotinic alpha 4 subunit
Acc ID: DOID:3331
Term: frontal lobe epilepsy
Definition: A localization-related (focal) form of epilepsy characterized by seizures which arise in the FRONTAL LOBE. A variety of clinical syndromes exist depending on the exact location of the seizure focus. Frontal lobe seizures may be idiopathic (cryptogenic) or caused by an identifiable disease process such as traumatic injuries, neoplasms, or other macroscopic or microscopic lesions of the frontal lobes (symptomatic frontal lobe seizures). (From Adams et al., Principles of Neurology, 6th ed, pp318-9)
Definition Source(s): MESH:D017034
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CHRNA4 ISORGD:103569068941CTDCTD Direct Evidence: marker/mechanism

PMID:12823585, PMID:14996991, PMID:17881519
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.