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CRRD ID: 14268113
Species: Sus scrofa
CRRD Object: Gene
Symbol: CHRNA4
Name: cholinergic receptor nicotinic alpha 4 subunit
Acc ID: GO:0007271
Term: synaptic transmission, cholinergic
Definition: The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
Definition Source(s): GOC:dos, Wikipedia:Cholinergic
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CHRNA4 IEAUniProtKB:O70174, ensembl:ENSMUSP0000006633814298760Ensembl GO_REF:0000107
CHRNA4 IBAMGI:MGI:87888, PANTHER:PTN001825425, RGD:2346, UniProtKB:P30532, UniProtKB:P43681, UniProtKB:Q1582214298760GO_Central (PMID:21873635)

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.