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GENE - TERM ANNOTATION REPORT

CRRD ID: 1562326
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ubr1
Name: ubiquitin protein ligase E3 component n-recognin 1
Acc ID: GO:0071596
Term: ubiquitin-dependent protein catabolic process via the N-end rule pathway
Definition: The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation.
Definition Source(s): GOC:mah, GOC:rb, PMID:19246002, PMID:9112437
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ubr1 IBAPANTHER:PTN000486924, PomBase:SPAC15A10.11, SGD:S00000341613792537GO_CentralPMID:21873635

 
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.