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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1562456
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Skp2
Name: S-phase kinase associated protein 2
Acc ID: CHEBI:9753
Term: troglitazone
Definition: A chromane that has formula C24H27NO5S.
Chemical ID: MESH:C057693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:16070866480464CTDtroglitazone results in decreased expression of SKP2 mRNA, troglitazone results in decreased expression of SKP2 protein

PMID:12717389, PMID:14618613, PMID:19140230
decreases response to substanceISORGD:16070866480464CTDSKP2 protein results in decreased susceptibility to troglitazone

PMID:12717389
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.